Pubmed Issues

A curated index of the top issues and topics most frequently cross-referenced within PubMed abstracts. Ranked by in-degree centrality — the number of inbound relations each entity receives in the knowledge graph.

• 1Alzheimer’s disease
  0.1185

  Disease

• 2PD-L1
  0.1047

  Protein

• 3colorectal cancer
  0.1047

  Disease

• 4Breast cancer
  0.0992

  Disease

• 5hepatocellular carcinoma
  0.0964

  Disease

• 6PD-1
  0.0771

  Protein

• 7Glioblastoma
  0.0744

  Disease

• 8immune checkpoint inhibitors
  0.0661

  Technology

• 9non-small cell lung cancer
  0.0661

  Disease

• 10CD8+ T cell
  0.0579

  Technology

• 11Lung cancer
  0.0579

  Disease

• 12CRISPR/Cas9
  0.0579

  Technology

• 13bladder cancer
  0.0551

  Disease

• 14Parkinson’s disease
  0.0523

  Disease

• 15Gastric cancer
  0.0496

  Disease

• 16Melanoma
  0.0496

  Disease

• 17Triple-negative breast cancer
  0.0468

  Disease

• 18Cervical cancer
  0.0413

  Disease

• 19Prostate cancer
  0.0386

  Disease

• 20tumor microenvironment
  0.0386

  Technology

• 21Mitophagy
  0.0386

  Technology

• 22STING
  0.0358

  Protein

• 23acute myeloid leukemia
  0.0358

  Disease

• 24EGFR
  0.0358

  Protein

• 25Multiple myeloma
  0.0303

  Disease

• 26Esophageal squamous cell carcinoma
  0.0303

  Disease

• 27mitochondria protein modules
  0.0303

  Technology

• 28Depression
  0.0303

  Disease

• 29Non-small cell lung cancer
  0.0275

  Disease

• 30Caenorhabditis elegans
  0.0275

  Technology

• 31Ovarian cancer
  0.0275

  Disease

• 32NF-kB
  0.0248

  Protein

• 33tumor immune microenvironment
  0.0248

  Technology

• 34Lymphoma
  0.0248

  Disease

• 35Psoriasis
  0.022

  Disease

• 36cGAS-STING pathway
  0.022

  Technology

• 37dendritic cells
  0.022

  Technology

• 38immunogenic cell death
  0.022

  Technology

• 39Diabetic kidney disease
  0.022

  Disease

• 40Cardiovascular disease
  0.022

  Disease

• 41Aortic stenosis
  0.022

  Disease

• 42Natural killer cells
  0.022

  Protein

• 43Chronic obstructive pulmonary disease
  0.022

  Disease

• 44Colon cancer
  0.022

  Disease

• 45Clear cell renal cell carcinoma
  0.022

  Disease

• 46NRF2
  0.022

  Gene

• 47Sickle cell disease
  0.022

  Disease

• 48cisplatin
  0.022

  Drug

• 49Inflammatory bowel disease
  0.022

  Disease

• 50TP53
  0.022

  Gene