📅 2026년 6월 13일 | PubMed 수집 논문 ★ 주요 논문 — 이번 수집의 하이라이트 Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy. (2026-06-10) CAR-T therapy is highly effective in hematologic malignancies but remains challenging in solid tumors. To address this challenge, here, we developed SHIFTERS (solid-tumor hallmark inducible, focused-ultrasound triggered enhanced…

📅 2026년 6월 12일 | PubMed 수집 논문 ★ 주요 논문 — 이번 수집의 하이라이트 Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B. (2026-06-11) We report the discovery and optimization of marstacimab, a novel monoclonal antibody targeting tissue factor pathway inhibitor…

📅 2026년 6월 11일 | PubMed 수집 논문 ★ 주요 논문 — 이번 수집의 하이라이트 Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin. Glial crosstalk surrounding amyloid-β (Aβ) plaques establishes a self-propagating inflammatory niche fueling Alzheimer’s disease (AD), yet the molecular triggers remain incompletely defined. We found that the…

📅 2026년 6월 9일 | PubMed 수집 논문 ★ 주요 논문 — 이번 수집의 하이라이트 Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial. Survodutide is a glucagon receptor/glucagon-like peptide-1 receptor dual agonist under investigation for treating obesity and related diseases. The SYNCHRONIZE-MASLD phase 3,…

📅 2026년 6월 8일 | PubMed 수집 논문 ★ 주요 논문 — 이번 수집의 하이라이트 High intrapancreatic fat deposition accelerates pancreatic ductal adenocarcinoma growth and metastasis with enrollment of FABP5 upregulation. A prospective observational study has shown that intrapancreatic fat deposition (IPFD) increases pancreatic ductal adenocarcinoma (PDAC) risk; however, the underlying mechanisms remain unclear. In…