VISTA is an immune checkpoint protein and immune regulation target that helps suppress T cell activation, making it relevant to tumor immune evasion and immunotherapy response prediction. It has been explored as an imaging target for assessing tumor immune status, especially through PET tracers based on the cyclic peptide antagonist scaffold AP1049 and its derivatives…
Osteoarthritis is a degenerative joint disease and a major disease context for studying growth factor mechanisms, with bibliometric work mapping research trends and knowledge structures from 2005 to 2024. It is strongly linked to the tgf beta superfamily, which was identified as the most frequently studied growth factor group in osteoarthritis research and is implicated…
Idiopathic pulmonary fibrosis (IPF) is a severely irreversible chronic lung disease characterized by progressive fibrosis, and it has been used as a disease context for immunopeptidome profiling and antifibrotic target discovery. In this setting, human IPF lung explants yielded fibrosis-associated peptides, including MAF116-124, which elicited human cytotoxic T lymphocytes that lysed IPF-derived myofibroblasts and M2-like…
Hyperthyroidism is an endocrine disorder characterized here as an immune-related adverse event after immune checkpoint inhibitor initiation, with a real-world cohort showing a 2.2% incidence within 12 months and an association with significant mortality. In this setting, ipilimumab was linked to a higher hazard of hyperthyroidism in Cox proportional hazards modeling, and risk was also…
Alpha-fetoprotein-producing gastric cancer (AFPGC) is a distinct gastric malignancy subtype with aggressive biology, elevated AFP, and clinicopathological and molecular features that differ from conventional gastric cancer. It is notable for biomarker-driven prognosis, where serum alpha fetoprotein correlates closely with tumor T-stage and outcome, and co-elevation of carcinoembryonic antigen can aid early diagnosis and prognostic evaluation,…
