Tubulin is a validated anticancer target and a core structural protein whose inhibition can block tubulin polymerization, making it important in cancer drug discovery. In the cited machine learning-driven repurposing workflow, autoqsar models were trained on curated tubulin inhibitors and glide docking was used to screen compounds against the colchicine-binding site, with biochemical assays confirming…
NY-ESO-1 is a cancer-testis antigen and immunotherapeutic target that is overexpressed in triple negative breast cancer (TNBC), where it has been evaluated for clinical relevance. In a systematic review/meta-analysis, expression was reported across 12 studies including 1,545 TNBC patients, with a pooled prevalence of 16.1% (PMID:41846058). Its main functional relevance is as an antigenic target…
Post-CAR T cell therapy lymphoproliferative disorders are rare lymphoproliferative and lymphomatous complications that arise after car t cell therapy, with an incompletely characterized clinical and biological spectrum. They can include both CAR-transgene-positive and transgene-negative lymphomas, and causal attribution is often difficult because multiple contributing factors may coexist. Proposed mechanisms include car transgene vector integration, pre-existing…
KK2269 is a tumor-targeted bispecific CD40 agonist antibody that activates antigen-presenting cells (APCs) selectively in the presence of EpCAM-positive tumors by binding CD40 on APCs and EpCAM on tumor cells. It is designed to localize immune stimulation to the tumor microenvironment rather than broadly activating CD40 systemically. In preclinical combination studies, KK2269 showed significant antitumor…
Aortic stenosis is a heart valve disease and, in this context, was studied as the outcome in a multi-omics Mendelian randomization framework using mendelian randomization to test causal associations. The analysis linked AS to multiple biological layers, including gut microbiome, blood metabolites, immune cell phenotypes, and circulating inflammatory proteins, suggesting a complex inflammatory-metabolic contribution to…
