T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of T-cell precursors and is being studied as a disease model and treatment target for apoptosis-based therapy and immunotherapy. It shows heterogeneous sensitivity to BH3-mimetics and NK cell-mediated killing, highlighting variable anti-apoptotic dependencies across samples. BH3-profiling was used to assess these dependencies in T-ALL, supporting functional…
Mitochondrial quality control (MQC) is a central mechanistic hub that maintains mitochondrial homeostasis through coordinated biogenesis, mitophagy, dynamics, proteostasis, and mitochondria-derived vesicles. It is implicated in chemotherapy-related cognitive impairment, where it is described as a key pathogenic framework, and in broader mitochondrial maintenance strategies using mitochondria-targeted hydrogels. MQC is also relevant to multiple chemotherapy classes…
Gut microbiota resilience is a biological property describing the capacity of intestinal microbial communities to resist, adapt to, and recover from perturbations, and it is framed as a determinant of human health and longevity. It functions as a public health target because fostering resilience may mitigate environmental insults, personalize interventions, and extend healthspan. The concept…
Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pulmonary vascular resistance that increases right ventricular afterload and can progress to hypertrophy and heart failure. In the clinical setting, it has been studied in the rehab ph trial using multidimensional molecular profiling, specifically metabolomics and proteomics, to capture molecular responses and assess biomarker stability….
Dopamine receptors are the receptors through which dopamine exerts its biological effects, and they are being explored as therapeutic targets in ischemia reperfusion injury because selective activation or inhibition under I/R stress may influence neuroplasticity, blood-brain barrier integrity, oxidative stress inhibition, and anti-apoptotic signaling. They are pharmacologically targeted by agents including bromocriptine, PD168077, piribedil, salvianolic…
