MDA-MB-231 is a human breast cancer cell line widely used as an experimental model for triple-negative breast cancer, especially in studies of drug delivery, gene manipulation, and anti-cancer screening. It serves as a functional assay system to test nanocarrier uptake and biological effects, and the provided key fact notes superior cellular uptake compared with conventional…
CD4+ T cells are a major helper T-cell population and, in this entry, serve primarily as a source cell population for engineering, including generation of engineered regulatory T cells. They are also used as an activated T-cell model to study immunometabolic reprogramming, where arginine-loaded MOF-808 and NH2-MIL-125 altered metabolism and, for MOF-808-Arg, increased oxidative phosphorylation…
Metagenomics is a sequencing-based analytical method used to profile gut microbiota at high resolution and to discover biomarkers from complex microbial communities. It is especially useful in integrated multi-omics studies, where metagenomic data can be combined with other layers to explain functional outputs such as antioxidant biomarker formation during fermentation. In diagnostics, it supports microbiome-based…
Atopic dermatitis is a chronic inflammatory skin disease that was analyzed as an outcome in single-cell transcriptomic mendelian randomization and co-localization studies, with GWAS summary statistics integrated from FinnGen (n = 31,245) and the GWAS Catalog (n = 22,474). It is linked to immune-mediated regulatory mechanisms and potential drug targets through single cell transcriptomic mendelian…
Epithelial cell adhesion molecule (epcam) is a tumor-associated cell-surface protein that serves as a target for the bispecific antibody kk2269, which activates antigen-presenting cells only in the presence of EpCAM-expressing tumor cells. It is also described as a stemness marker in hepatocellular carcinoma, where AFP ablation downregulated EpCAM, linking it to cancer stemness programs and…
