Chronic obstructive pulmonary disease (COPD) is a heterogeneous chronic lung disease in which multi-omics profiling is being used to define biologically meaningful endotypes and improve clinical categorization. It is associated with immunosenescence, which is described as playing a crucial role in COPD pathogenesis and progression. Proteomic studies have identified reproducible circulating markers—club cell secretory protein,…
3CLpro is a viral protease target, specifically the 3C-like protease used in inhibitor and modulator discovery for human norovirus and SARS-CoV-2. It functions as a binding target for screened compounds, and the entry highlights both HuNoV 3CLpro and SARS-CoV-2 3CLpro as relevant contexts. In human norovirus research, advanced virtual screening identified candidate inhibitors/modulators against chembl2028556,…
Bovine serum albumin (BSA)-induced allergy is an experimental disease model used to study allergic responses triggered by bovine serum albumin. It appears to function as a platform for identifying active metabolites and diagnostic biomarkers, with multi-omics analysis showing 61 differential metabolites validated in plasma. The model is linked to perturbation of the complement and coagulation…
Treatment-resistant depression (TRD) is a depressive disorder in which standard treatments have failed, and it is being studied both as a clinical target for psilocybin assisted psychotherapy and as a source of patient-derived iPSC models. In a translational study, neurons from individuals with TRD were compared with healthy volunteers to test rapid-acting antidepressants, including doi,…
MDA-MB-231 is a human breast cancer cell line widely used as an experimental model for triple-negative breast cancer, especially in studies of drug delivery, gene manipulation, and anti-cancer screening. It serves as a functional assay system to test nanocarrier uptake and biological effects, and the provided key fact notes superior cellular uptake compared with conventional…
