Pubmed Today 2026Jun12

We report the discovery and optimization of marstacimab, a novel monoclonal antibody targeting tissue factor pathway inhibitor (TFPI), for the treatment of hemophilia A and B. Hybridoma and phage display approaches identified antibodies that blocked the TFPI: coagulation factor Xa (FXa) interaction….

이 논문은 TFPI 표적 항체의 후보물질 최적화 과정을 잘 보여주는 전임상·개발연구다. 현재는 승인 약물로 이어져 상업적 의미가 매우 크다. 다만 본문 자체는 인간 임상 효능을 직접 제시하지 않으므로 임상 점수는 제한적으로 본다.

The neoCARHP aimed to investigate the efficacy and safety of investigator-selected taxane (docetaxel, paclitaxel, or nab-paclitaxel) plus trastuzumab and pertuzumab, with carboplatin (TCbHP) or without carboplatin (THP), in stage II and III human epidermal growth factor receptor 2 (HER2)-positive br…

무작위 3상 비열등성 연구로 임상적 의미가 크다. 다만 초록만으로는 결과가 없어 실제 변화 가능성은 제한적으로 판단해야 한다. 기전적 새로움은 크지 않지만 치료 최적화 측면에서 가치가 있다.

The phase II GeparNuevo trial investigated whether adding durvalumab to neoadjuvant chemotherapy (NACT) only in patients with early triple-negative breast cancer cT1b-cT4a-d would improve pathologic complete response (pCR) rate and patient survival. Hundred and seventy-four patients were randomly as…

무작위 2상 연구로서 임상적 신호가 분명하다. 전체생존율까지 개선되어 의미가 크지만, 아직 확증적 3상 근거는 아니다. 기전적 새로움은 제한적이지만 치료 전략 재검토 가능성은 높다.

The Nipah and Hendra viruses (NiV and HeV, respectively) are highly pathogenic, with case fatality rates of 40 to 75%, representing substantial public health threats. Although one monoclonal antibody (mAb), mAb102.4, has advanced through phase 1 clinical trials, there remains a critical need for app…

동물모델에서 유효성과 내성 회피 가능성을 함께 보여준 점이 강점이다. 다만 아직 전임상 단계이므로 임상적 파급은 제한적이며, 실제 사람 대상 효능과 안전성 검증이 필요하다.

Orthoflaviviruses, including Zika (ZIKV), dengue, Japanese encephalitis, and West Nile viruses, cause diverse clinical syndromes and threaten human health. Identifying factors that inhibit orthoflavivirus infection could lead to antiviral countermeasures. Here, we conducted a genome-wide CRISPR acti…

이 연구는 SPART가 여러 orthoflavivirus를 억제하는 숙주 인자임을 규명한 기초연구다. 임상 근거는 아직 전임상 수준이지만, 기전이 명확하고 동물모델 검증이 있어 후속 항바이러스 타깃으로서 의미가 있다.

Invasive mold diseases (IMDs) such as mucormycosis and aspergillosis carry high mortality despite optimal antifungal therapy. Adjunctive immunomodulation, including anti-PD-1 antibodies and interferon-γ, may help restore antifungal immunity in severely ill patients. We implemented multidiscipl…

The purposes of the cross-sectional survey were to investigate among a sample of post-partum women in Italy the attitudes and the behaviors about the respiratory syncytial virus (RSV) infant monoclonal antibody and to explore any associations with different characteristics.The survey was conducted b…

Gemtuzumab ozogamicin (GO) is a humanized IgG4 anti-CD33 monoclonal antibody conjugated to the cytotoxic derivative of calicheamicin. GO was the first antibody-drug conjugate (ADC) approved for the treatment of patients with CD33+ acute myeloid leukemia (AML). Although GO exhibits cytotoxic activity…

BACKGROUND Management of infected segmental defects of the femoral diaphysis is challenging because infection control, restoration of stability, and reconstruction of bone loss must all be achieved. The induced membrane technique, also known as the Masquelet technique, is a 2-stage reconstructive me…

Malonyl-CoA is a key precursor for the biosynthesis of numerous active natural products. Malonyl-CoA synthetases (MatBs) provide a direct route to malonyl-CoA from malonic acid and CoA. However, the limited availability of plant MatBs with high catalytic efficiency restricts their application in bio…

Amivantamab, an EGFR-MET bispecific antibody with immune cell-directing activity, is approved in non-small cell lung cancer (NSCLC). Effective treatments are limited for chemorefractory metastatic colorectal cancer (mCRC)….

HFE-related hereditary hemochromatosis is caused by loss-of-function mutations in the HFE gene, leading to excessive intestinal iron absorption and hepatic deposition. The C282Y variant in homozygosity accounts for 80-90% of diagnosed cases. If untreated, iron accumulation can cause liver fibrosis, …

임상적으로는 아직 동물모델 수준이므로 제한적이다. 그러나 in vivo base editing이라는 점에서 발견 가치가 매우 높고, 질환 수정 치료로 이어질 가능성이 있다. 상업적으로도 희귀질환 유전자치료 파이프라인으로서 의미가 크다.

Delivery of gene therapy vectors efficiently targeted to any somatic cell remains a key barrier for the development of genetic medicines. While rodent models provide insights into vector biodistribution and cellular tropism, their anatomical and physiological differences from humans limit their tran…

대동물 기반 유전자 전달 평가 플랫폼을 제시한 연구다. 임상 효능을 직접 보여주지는 않지만, 종간 차이로 인한 번역 한계를 줄일 수 있는 도구로서 의미가 있다. 상용화는 간접적이지만 유전자치료 벡터 개발 과정에서 활용 가치가 있다.

Magnetic particle hyperthermia (MPH), the mild heating of solid tumors with magnetic nanoparticles, is an emerging treatment modality used as an adjuvant to therapies such as ionizing radiation. MPH can be paired with magnetic particle imaging (MPI) hardware to improve thermal treatment planning, sp…

The organ- and stage-specific diversity of megakaryocytes (MKs) has prompted a reassessment of their distribution and functions. By integrating single-cell transcriptomic data across multiple organs and developmental stages, we identified previously unreported MK and platelet markers, including Tnik…

다기관 단일세포 통합과 기능 검증을 결합해 megakaryocyte의 조직 특이성과 다양성을 새롭게 제시한 연구다. 임상적 직접성은 아직 제한적이지만, 기초과학적 파급력은 크고 후속 번역 연구로 이어질 가능성이 있다.

The lack of accurate human models that recapitulate pancreatic ductal adenocarcinoma (PDAC) initiation has hindered therapeutic development. Using pluripotent stem cell-derived pancreatic progenitor organoids, we established a human PDAC model that faithfully reproduces the genetic, epigenetic, and …

인간 PDAC 초기화 과정을 재현한 오가노이드 모델을 제시한 점이 핵심이다. CDKN2A와 TET1 축의 역할을 규명해 발견 가치가 매우 높다. 다만 아직 전임상 단계로, 임상적 파급력은 제한적이다.

Despite widespread clinical use of glucagon-like peptide-1 receptor (GLP-1R) agonists for metabolic disease, their neuropsychiatric effects remain poorly understood and controversial. Here, we demonstrate that liraglutide alleviates depression through a gut-brain pathway that operates independently …

마우스 기반 기전 연구로, liraglutide의 항우울 효과를 미생물-엔도칸나비노이드 축으로 설명한 점이 핵심이다. 임상 근거는 아직 없어서 clinical 가치는 낮지만, 발견 자체의 새로움은 매우 크다. 기존 GLP-1 약물의 적응증 확장 가능성을 시사하나, 인간 검증이 필요하다.

Acute kidney injury (AKI) lacks disease-modifying therapies, partly because cell type-specific injury programs remain incompletely resolved and tissue mechanisms are not readily translated into clinically accessible biomarkers. We constructed a cross-scale, multi-omics atlas to prioritize candidate …

인간 오믹스와 동물모델, 세포실험을 연결해 TRIM28을 AKI 후보 조절인자로 제시한 점이 의미 있다. 다만 아직 전임상 단계이며, 치료제나 바이오마커로의 임상적 검증은 부족하다.

Despite substantial advances in targeting KRASG12C, tumor acquired resistance to KRASG12C inhibitors (KRASG12Ci) remains a major barrier to progress. Here, we report ATF3-driven asparagine metabolic reprogramming as a key convergence point of KRASG12Ci resistance. Multi-omics profiling of resistant …

KRASG12C 억제제 내성의 새로운 대사 기전을 제시한 연구다. 환자유래 모델까지 확인해 의미가 있으나, 아직 전임상 수준이므로 임상적 파급력은 제한적이다. 기전적 새로움과 후속 병용전략 가능성은 충분히 주목할 만하다.

Post-transplant rejection and infection remain significant obstacles to long-term patient survival. However, there is currently no standardized assay to simultaneously assess an individual patient’s risk for both complications. Here, we demonstrate that T cell receptor (TCR)-CD3 oligomers on extrace…

이 연구는 이식 거부반응과 감염을 구분하는 새로운 EV 기반 진단법을 제시한다. 소규모 임상 코호트에서 성능이 괜찮아 임상적 가능성은 있으나, 아직 검증 규모가 작아 확정적 결론은 어렵다. 상용화 측면에서는 비침습 검사로서 매력적이지만 추가 대규모 검증이 필요하다.

Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder needing long-term immunosuppressive therapy. Eculizumab is a promising treatment, but real-world evidence on its efficacy and safety is limited….

Early identification of patients at risk of developing severe disease remains a clinical challenge for scrub typhus. We aimed to identify serum cytokine profiles associated with disease severity and validate potential biomarkers for early risk stratification of patients with scrub typhus. We conduct…

BackgroundUpper extremity (UE) recovery in individuals with subacute stroke often plateaus despite conventional physical therapy (CPT). Smartphone-based virtual reality (VR) represents a low-cost, semi-immersive approach that may enhance task-specific training and neuroplasticity.ObjectiveTo determi…

Esophageal squamous cell carcinoma (ESCC) remains a therapeutic challenge, characterized by poor prognosis and limited treatments. Despite the established role of cancer stemness in progression and resistance, current stemness-targeting strategies, including Notch pathway inhibition, have shown subo…

임상 근거는 아직 전임상 수준으로 보이며 인간 환자 데이터는 제시되지 않았다. 다만 METTL3-m6A-JAG2 축을 이용한 병용 전략은 기전적으로 흥미롭고 후속 개발 가치가 있다.

Chimeric antigen receptor T cell (CAR T) immunotherapies have transformed cancer treatment. These therapies typically involve lentiviral vector-mediated CAR gene integration, followed by reinfusion into patients, necessitating rigorous quality control. Critical parameters, including transduction eff…

Anti-amyloid therapy (AAT) protocol complexity may widen specialty dementia care access gaps. The University of Colorado (CU) Advanced Therapy in Neurodegenerative Disorders (ATND) Clinic is within the CU-Memory Disorders Clinic (CU-MDC). The aim of this study is to report initial CU-ATND real-world…

Monitoring T cell repertoires in human tissues provides important insights into immune response mechanisms in cancer, infectious diseases, and autoimmunity. However, retrieving VDJ information from single-cell and spatial transcriptomics workflows with 3′-barcoding of cDNA remains resource-intensive…

Approximately one billion people worldwide live with a mental disorder, yet access to minimally adequate treatment remains low. Against this backdrop, general-purpose generative artificial intelligence (GenAI) systems have rapidly expanded into informal mental health support. OpenAI disclosed that r…

Digital therapeutics (DTx) are evidence-based software interventions with the potential to treat health conditions. However, uptake remains limited by low public awareness and overly complex patient education materials that exceed recommended readability levels. Large language models (LLMs) may simp…

Behavioral therapies are effective in the management of irritable bowel syndrome (IBS). Mahana™ IBS is a mobile phone application designed to deliver 10 sessions (10-12 weeks) of gut-directed cognitive behavioral therapy (CBT) to adults with IBS….

Objective.Multimodal medical image registration has extensive applications in clinical diagnosis and is fundamental for a series of medical analysis tasks. However, the presence of modality differences makes the registration process challenging. Existing methods often employ modality-independent fea…

Fexuprazan, a novel potassium-competitive acid blocker, has emerged as a promising alternative to proton pump inhibitors for the treatment of gastroesophageal reflux disease (GERD). Although its efficacy has been confirmed in clinical trials, real-world evidence on fexuprazan safety and effectivenes…

Radiation-induced lung injury (RILI) represents a severe, therapy-refractory complication of thoracic radiotherapy. Although neutrophils have been implicated in RILI pathogenesis, the specific pathogenic subsets and the molecular mechanisms governing their recruitment and functional specialization r…

임상 근거는 아직 전임상 수준으로 보이며 직접적인 환자 적용성은 낮다. 다만 기전이 비교적 선명하고 표적화 가능성이 있어 후속 연구 가치가 있다. 상업성은 초기 단계이며 개발 리스크가 크다.

Multi-omics data offer unprecedented insights into complex biological systems, yet their high dimensionality, sparsity, and intricate interactions pose significant analytical challenges. Network-based approaches have advanced multi-omics research by effectively capturing biologically relevant relati…

Sarcopenia lacks causal mechanisms and translatable targets. We integrated virtual gene knockout with multi-omics (n = 238 biopsies, 5 GEO cohorts) and single-cell RNA-seq (n = 10, 12,847 cells) to identify fibroblast-specific drivers. After ComBat batch correction…

Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and lethal malignancy, with its complex tumor microenvironment (TME) severely limiting therapeutic efficacy. Efferocytosis, a key process by which macrophages clear apoptotic cells, has been demonstrated to influence tumor initiation and p…

Skin aging is an increasingly serious clinical problem with limited treatment options. Wharton’s jelly mesenchymal stem cells (WJMSCs) represent a promising regenerative strategy. However, their mechanisms of action remain to be fully elucidated through integrated multi-omics approaches….

Leucine-rich repeat kinase 2 (LRRK2), initially identified as a gene implicated in Parkinson’s disease, is increasingly recognized for its influence on aging and associated disorders. However, its systemic roles in biological aging remain poorly understood….

Sheep pulmonary adenocarcinoma (SPA), a chronic contagious lung neoplasm induced by jaagsiekte sheep retrovirus (JSRV), represents a unique animal model for studying virus-driven lung carcinogenesis. This study aimed to systematically dissect host transcriptional reprogramming in naturally infected …

Qishen Yiqi Dripping Pills (QSYQ), composed of Astragalus membranaceus Fisch. ex Bunge, Salvia miltiorrhiza Bunge, Panax notoginseng (Burkill) F.H.Chen, Dalbergia odorifera T.C.Chen have been included in the Pharmacopoeia of the People’s Republic of China and are known to alleviate myocardial ischem…

Intestinal fibrosis is a severe complication of Crohn’s disease (CD). While ADAMDEC1 has been identified as a marker for specific fibroblast subsets, its functional role in fibrogenesis remains unclear. This study aimed to elucidate the pathophysiological significance of ADAMDEC1 in the fibrotic cas…