📅 2026년 6월 8일 | PubMed 수집 논문
★ 주요 논문 — 이번 수집의 하이라이트
High intrapancreatic fat deposition accelerates pancreatic ductal adenocarcinoma growth and metastasis with enrollment of FABP5 upregulation.
A prospective observational study has shown that intrapancreatic fat deposition (IPFD) increases pancreatic ductal adenocarcinoma (PDAC) risk; however, the underlying mechanisms remain unclear. In this study, we established a C57BL/6J mouse model of IPFD by feeding them Gubra Amylin NASH (GAN), a hi…
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High intrapancreatic fat deposition accelerates pancreatic ductal adenocarcinoma growth and metastasis with enrollment of FABP5 upregulation.
A prospective observational study has shown that intrapancreatic fat deposition (IPFD) increases pancreatic ductal adenocarcinoma (PDAC) risk; however, the underlying mechanisms remain unclear. In this study, we established a C57BL/6J mouse model of IPFD by feeding them Gubra Amylin NASH (GAN), a hi…
이 연구는 췌장 내 지방 축적이 PDAC 진행과 전이를 촉진할 수 있음을 동물모델과 세포실험으로 보여준다. 임상 근거는 없지만 기전적 타당성과 표적 가능성이 있어 후속 전임상 개발 가치가 있다.
Modeling HIV dynamics under broadly neutralizing antibodies: The potential role of cell-to-cell virus transmission.
Cell-to-cell transmission of human immunodeficiency virus (HIV) presents a significant challenge to combination antiretroviral therapy (cART), as this mode of infection is markedly more efficient and often exhibits increased resistance to antiviral agents compared to cell-free viral infection. Howev…
Sleep-related breathing disorders beyond infancy following open spina bifida repair.
In patients with repaired open spina bifida, there are limited data on respiratory outcomes beyond the first year of life. We hypothesize that after 1 year of age there is 1) resolution of sleep-related breathing disorders (SRBD), 2) improvement of oxygenation and 3) no difference in SRBD betwe…
A body roundness index (BRI)-based predictive model for metabolic syndrome in perimenopausal and postmenopausal women-from a cross-sectional machine learning study to a longitudinal dynamic assessment.
Metabolic syndrome (MetS) is highly prevalent among perimenopausal and postmenopausal women and poses a major public health challenge because of its association with cardiovascular disease, type 2 diabetes, and premature mortality. However, prediction tools for this population remain limited. Theref…
Integrative multi-omics identifies a glycosylation-based prognostic framework and nominates ALG3 for targeted therapy in bladder cancer.
Bladder urothelial carcinoma (BLCA) exhibits heterogeneous outcomes, creating an urgent need for reliable prognostic biomarkers. Glycosylation modifications are crucial in cancer but understudied for BLCA stratification….
Comprehensive multi-omics pan-cancer analysis revealed that ANTXR1 is a potential biomarker for diagnosis and immunotherapy.
Anthrax toxin receptor 1 (ANTXR1, TEM8) has been implicated in tumor angiogenesis and progression, yet its pan-cancer immunological role remains incompletely defined….
Identification of macrophage polarization-related genes for esophageal cancer risk: a multi-omics Mendelian randomization analysis.
This study aims to identify macrophage polarization (MP)-related genes implicated in esophageal cancer (EC) by integrating methylation quantitative trait loci (mQTL), expression QTL (eQTL), and protein QTL (pQTL) data with EC genome-wide association study (GWAS) data….
Quantifying the effect of threshold-triggered interventions on hepatitis E virus outbreaks.
Hepatitis E virus (HEV) presents a major public health threat in low-resource and displaced populations, where poor sanitation and limited access to healthcare facilitate transmission. Despite the availability of water, sanitation, and hygiene (WASH) programs and a licensed HEV vaccine for outbreak …
Association of intensive blood pressure lowering with health-related quality of life after endovascular thrombectomy: a post-hoc analysis of the ENCHANTED2/MT trial.
Intensive blood pressure (BP) targets of less than 120 mm Hg have been shown to worsen functional outcomes after endovascular thrombectomy (EVT) for acute ischemic stroke. However, their effects on self-reported health-related quality of life (HRQoL) remain uncertain….