Clear cell renal cell carcinoma

Byaibio

Clear cell renal cell carcinoma (ccRCC) is the most prevalent and aggressive subtype of kidney cancer, and advanced disease is often marked by limited therapeutic response. It is characterized by metabolic reprogramming and an immunologically active but suppressive tumor microenvironment, with recent work linking upr signaling to immune regulation and macrophage polarization. Multi-omics profiling identified ectopic olfactory receptors as putative drivers of tumor progression and prognostic indicators, while the Key Facts note that bulk transcriptomic and single-cell multi-omics analyses supported OR-based prognostic modeling and tumor clustering with unfavorable prognostic signatures. Specific OR-related findings include or2t10 enrichment in malignant epithelial cells with invasive/metastatic potential and or51e1 expression in pericytes associated with vascular remodeling and angiogenic activity. Additional studies connect slc16a3-driven lactate remodeling to immune evasion via an autocrine GPR81-ERK-c-MYC feedback loop, and dock4 expression to favorable prognosis and immune infiltration. The disease context also includes signaling axes involving cebpb and mif, underscoring ccRCC as a major setting for biomarker discovery and immune-microenvironment research.

Tumor progression and prognosis

  • Multi-omics profiling identified ectopic olfactory receptors as putative drivers of tumor progression and prognostic indicators in ccRCC, with OR-based prognostic modeling and tumor clustering revealing unfavorable prognostic signatures. (PMID:41863682)
  • or2t10 was enriched in malignant epithelial cells and associated with invasive and metastatic potential. (PMID:41863682)
  • or51e1 was predominantly expressed in pericytes and correlated with vascular remodeling and angiogenic activity. (PMID:41863682)
  • The disease is described as the most prevalent and aggressive subtype of kidney cancer with limited therapeutic response in advanced stages. (PMID:41863682)

Immune regulation and tumor microenvironment

  • upr signaling was linked to immune regulation in ccRCC, with UPR-cebpb–mif signaling associated with macrophage polarization and an immunosuppressive tumor microenvironment. (PMID:41936685)
  • The tumor context was analyzed using bulk transcriptomic and single-cell multi-omics datasets to define prognostic signatures in the tumor microenvironment. (PMID:41863682)
  • ccRCC was also discussed as a setting for metabolic reprogramming that shapes immune regulation. (PMID:41936685)

Metabolism and immune evasion

  • slc16a3-induced lactate remodeling drives immune evasion in ccRCC via an autocrine GPR81-ERK-c-MYC feedback loop. (PMID:42028950)
  • This work frames lactate metabolism as a mechanism of checkpoint blockade resistance in renal cancer. (PMID:42028950)
  • The cancer type was highlighted as involving metabolic reprogramming with immune consequences. (PMID:41936685)

Biomarkers and clinical significance

  • Elevated dock4 expression correlated with favorable prognosis and immune infiltration in ccRCC. (PMID:41821478)
  • ccRCC served as the disease context for assessing DOCK4 expression and clinical significance in the most prevalent kidney cancer subtype. (PMID:41821478)
  • The literature collectively supports ccRCC as a biomarker-rich disease area for prognosis, immune infiltration, and therapeutic resistance studies. (PMID:41821478)