Immunotherapy Summary immunotherapy is a therapeutic approach that modulates the immune system to produce anti-tumor effects, and in this entry it is used as a treatment context for outcome prediction and clinical evaluation. A clinician-deployable deep hypergraph model integrating clinical and CT radiomics predicted deep hypergraph for nsclc immunotherapy outcomes in NSCLC, highlighting a data-driven…
B7-H3 Summary B7-H3 (CD276) is a tumor-associated immune-related protein that is markedly upregulated across EGFR-positive malignancies while showing minimal expression in healthy tissues, making it a tumor-selective binding target. It can mediate cis-inhibition in the context of an EGFR/B7-H3 bispecific antibody, supporting a mechanism for enhanced anti-tumor efficacy with reduced toxicity (PMID:41735305). In colorectal cancer,…
Immunotherapy Summary immunotherapy is a therapeutic approach that harnesses or modulates the immune system to produce anti-tumor effects, and in this entry it is used as a treatment context for outcome prediction and intervention. In NSCLC, a clinician-deployable deep hypergraph model, deep hypergraph for nsclc, integrated clinical data and CT radiomics to predict immunotherapy outcomes,…
B7-H3 Summary B7-H3 (CD276) is a tumor-associated immune-related protein that functions as a tumor-selective binding target and mediator of cis-inhibition. It is markedly upregulated across EGFR-positive malignancies while showing minimal expression in healthy tissues, supporting its use in selective cancer targeting. In a reported bispecific antibody strategy, ibi334 leverages B7-H3-mediated cis-inhibition of EGFR to enhance…
Immunotherapy Summary immunotherapy is a therapeutic approach that modulates the immune system to improve anti-tumor responses, and in this entry it is used as a treatment context for outcome prediction in NSCLC. A clinician-deployable deep hypergraph model, deep hypergraph for nsclc, integrated clinical data and CT radiomics to predict immunotherapy outcomes in non-small cell lung…
