B7-H3 Summary B7-H3 (CD276) is a tumor-associated immune-related protein that is markedly upregulated across EGFR-positive malignancies while showing minimal expression in healthy tissues, making it a tumor-selective binding target. It can mediate cis-inhibition in the context of the reported EGFR/B7-H3 bispecific antibody ibi334, which was designed for tumor-selective binding and enhanced anti-tumor efficacy with reduced…
Immunotherapy Summary immunotherapy is a therapeutic approach that modulates the immune system to produce anti-tumor effects, and in this entry it is used as a treatment context for outcome prediction and clinical evaluation. In NSCLC, a clinician-deployable deep hypergraph model integrating clinical and CT radiomics predicted immunotherapy outcomes, highlighting a data-driven approach to patient stratification…
Natural killer (NK) cells are infiltrating immune effector cells that mediate cytotoxic activity against infected and transformed cells, and they are a major focus of cancer immunology because tumors can evade NK-cell surveillance and killing. In the tumor microenvironment, NK-cell infiltration increased after NE@LTT@DNase1 treatment and after inhalable Cryo-Shocked Tumor Cell therapy, indicating recruitment of…
Regulatory T cells are an immune-suppressive T-cell population that helps maintain immune tolerance but can also be co-opted by tumors to drive immune evasion. In this entry, their differentiation is promoted by tumor-derived exosomes, and they are linked to an immunosuppressive tumor microenvironment, including KSR2-associated metabolic reprogramming. They are relevant to cancer immunology and anti-tumor…
B7-H3 Summary B7-H3 (CD276) is a tumor-associated immune-related protein that functions as a tumor-selective binding target and mediator of cis-inhibition. It is markedly upregulated across EGFR-positive malignancies while showing minimal expression in healthy tissues, making it attractive for selective targeting. A 2026 Nature Communications study (PMID:41735305) reported an ibi334-based bispecific antibody mechanism in which B7-H3-mediated…
