Lifespan is a core biogerontology outcome measure describing the chronological duration from birth to biological death, and it is presented as a biological trait that is relatively malleable and can be manipulated through existing mechanisms. The literature here frames lifespan as an aging-related endpoint that can be extended by interventions, including those affecting autophagy, with…
Non-coding RNAs are epigenomic-related molecular regulators that act through regulatory RNA networks rather than encoding proteins, and here they are described as part of dysregulated molecular regulation in chronic inflammation, steroid resistance, and disease progression. They are implicated in autoimmune disease as prognostic biomarkers and indicators of autoimmune pathology, and in cardiovascular disease as a…
Psilocybin is a classic serotonergic psychedelic and oral serotonin 2a/sigma 1 receptor-active compound that has been studied as a rapid-acting antidepressant and as a candidate for restoring mitochondrial integrity. In iPSC-derived neurons, it showed time-dependent transcriptomic effects, and its overall gene expression responses were highly correlated with other agents at matched timepoints, supporting a shared…
Graft-versus-host disease (allogeneic haematopoietic stem cell transplantation-associated GVHD) is a major immune-mediated complication of allo-HSCT in which donor immune cells attack host tissues, and it remains a central research focus because it must be balanced against graft-versus-leukaemia effects. Engineered regulatory T cells (engineered regulatory t cells) have shown in vivo reversal of GVHD in preclinical…
Cellular senescence is an irreversible cell-cycle arrest state and a hallmark of biological aging, with major roles in neurodegenerative disorders and diabetic kidney disease. It is implicated in brain aging and neurodegeneration, and in diabetic kidney disease it is described as a recognized driver of pathogenesis and a therapeutic focus for senotherapeutic approaches. Recent studies…
