Lifespan

Lifespan is a core biogerontology outcome measure describing the chronological duration from birth to biological death, and it is presented as a biological trait that is relatively malleable and can be manipulated through existing mechanisms. The literature here frames lifespan as an aging-related endpoint that can be extended by interventions, including those affecting autophagy, with the Key Facts noting that reviewed interventions are described as extending lifespan across species. This makes it relevant to aging and healthy-aging research rather than a single disease pathway, with emphasis on mechanism-based modulation of organismal survival. Recent discussion also highlights the distinction between lifespan and healthspan, underscoring that lifespan ends at death even when functional health may decline earlier. Overall, the cited work suggests that lifespan is not fixed and may be altered by targeting conserved biological processes such as autophagy.

Aging and Healthy Aging

  • Interventions affecting autophagy were discussed as extending lifespan in aging-related contexts. (PMID:41577121)
  • The review links autophagy to healthy aging and organismal survival across species. (PMID:41577121)
  • lifespan is described as an aging-related outcome measure that can be improved by mechanism-based interventions. (PMID:41577121)
  • The Key Facts indicate that reviewed interventions extend lifespan across species, supporting cross-species conservation of the effect. (PMID:41577121)

Biogerontology and Conceptual Frameworks

  • lifespan is defined as the chronological duration from birth to biological death. (PMID:41903027)
  • The article frames lifespan as a core concept in biogerontology. (PMID:41903027)
  • The distinction between lifespan and healthspan is emphasized, with lifespan ending at death. (PMID:41903027)
  • lifespan is described as a biological trait that is relatively easy to manipulate by leveraging existing biological mechanisms. (PMID:41366834)
  • A broad review of aging presents lifespan as malleable rather than fixed. (PMID:41366834)