HSP90, or heat shock protein 90, is a molecular chaperone that helps maintain protein homeostasis and is significantly upregulated in heat stress proteomic studies. It is implicated in inflammatory and cardiovascular disease mechanisms, where targeting stat1 and ccl8-driven inflammation and mitigating mitochondrial dysfunction were reported to attenuate hypertension-induced atrial fibrillation. In cancer, HSP90 inhibition was…
Longevity is a biological and experiential topic concerned with extended lifespan and the factors that shape survival beyond the species-typical average, with the review specifically synthesizing qualitative research on centenarians’ views and experiences. It is framed probabilistically rather than as a fixed limit, and recent work treats it as an outcome influenced by organelles and…
HSP70 is a conserved heat shock protein and stress-response factor that is significantly upregulated under heat stress, consistent with its role in proteostasis and cellular stress adaptation. It appears in the heat stress response, where proteomic studies showed marked induction, and it is also part of the CDK7-HSP70 stress axis disrupted by cdk7 targeting. In…
Antisense oligonucleotides are short RNA-directed therapeutic molecules that bind target transcripts or regulatory RNAs to modulate gene expression, often by promoting degradation or functional silencing. In this entry, they are used to deplete enhancer RNAs and silence bcl11a, disrupting enhancer-dependent epigenetic insulation and reactivating fetal hemoglobin (HbF) in adult erythroid cells. They are also being…
Gastrointestinal cancers are a heterogeneous group of malignancies arising in the digestive tract and are notable for generally low response rates to immune checkpoint inhibitors, especially in refractory microsatellite-stable gastric cancer. They are increasingly studied through multi omics approaches, which are reshaping biological understanding and clinical management, including precision oncology, liquid biopsy, and ctDNA monitoring….
