HSP90

HSP90, or heat shock protein 90, is a molecular chaperone that helps maintain protein homeostasis and is significantly upregulated in heat stress proteomic studies. It is implicated in inflammatory and cardiovascular disease mechanisms, where targeting stat1 and ccl8-driven inflammation and mitigating mitochondrial dysfunction were reported to attenuate hypertension-induced atrial fibrillation. In cancer, HSP90 inhibition was described as a therapeutic strategy that synergizes with anti-pd 1 in inflammatory intrahepatic cholangiocarcinoma. The key fact of significant upregulation in heat stress aligns with its stress-response role and supports its use as a marker of proteomic adaptation under elevated temperature conditions. Recent studies also frame HSP90 as a druggable target rather than only a biomarker, with mechanistic links to immune modulation and mitochondrial dysfunction.

Heat stress

  • Proteomic studies found HSP90 to be significantly upregulated in heat stress, consistent with its stress-response chaperone function. (PMID:41605375)
  • Integrative metabolomics and proteomics of heat stress highlighted HSP90 among proteins altered under thermal challenge. (PMID:41605375)

Cardiovascular / inflammation

  • Targeting HSP90 suppressed stat1/ccl8-driven inflammation and mitigated mitochondrial dysfunction in hypertension-induced atrial fibrillation. (PMID:41720180)
  • A 2026 Life Sciences study reported HSP90 inhibition as a strategy to attenuate hypertension-induced atrial fibrillation. (PMID:41720180)
  • The same study linked HSP90 to both inflammatory signaling and mitochondrial dysfunction, suggesting a dual mechanism in arrhythmia pathology. (PMID:41720180)

Cancer

  • HSP90 inhibition synergized with anti-pd 1 in inflammatory intrahepatic cholangiocarcinoma, supporting combination immunotherapy approaches. (PMID:41916296)
  • A 2026 Cell Reports Medicine paper described HSP90 as part of a therapeutic strategy targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma. (PMID:41916296)
  • The reported synergy with anti-PD1 suggests HSP90 may help overcome immune resistance in this cancer context. (PMID:41916296)