Metabolomics

Byaibio

Metabolomics is a high-throughput metabolomics approach that profiles small-molecule metabolites to reveal phytochemical fingerprints, biomarker pathways, and disease-associated molecular responses. It is used across diabetes intervention in phyllanthus niruri, inflammatory bowel disease, psoriasis, drought-stress biology, pulmonary arterial hypertension, bull fertility, and cardiovascular risk prediction, and it is also being integrated with microbiome, proteomics, and AI frameworks. In Phyllanthus species, the approach was described as unlocking therapeutic avenues for diabetes, while in clinical and translational settings it has been applied to dried-blood-spots, low-microliter plasma workflows, and multidimensional profiling of trial samples. Recent literature highlights its role in improving diagnostic accuracy, capturing biomarker stability, and translating metabolomic signatures into predictive tools, including untargeted profiling and multi-omics integration. Specific advances include compatibility with orthogonal extraction from low-volume plasma, and use of ternary solvent mixtures such as methanol, acetonitrile, and acetone to preserve metabolomic readouts. Overall, metabolomics functions as a central omics layer for mechanistic discovery and biomarker development in precision medicine, agriculture, and toxicology.

Diabetes / Phytotherapy

  • An updated review described metabolomics as an analytical approach to uncover therapeutic avenues and deepen understanding of antidiabetic properties in phyllanthus niruri species. (PMID:41539677)
  • The review specifically framed metabolomics as a way to analyze phytochemical fingerprints and biomarker pathways relevant to diabetes intervention. (PMID:41539677)
  • Metabolomics was presented as a tool for translating traditional knowledge into clinical-trial-relevant evidence for Phyllanthus-based interventions. (PMID:41539677)

Microbiome, Inflammation, and Skin Disease

  • Metabolomic data integrated with microbiome data improved diagnostic accuracy in inflammatory bowel disease. (PMID:41220286)
  • In psoriasis research, metabolome alterations in skin and plasma were reviewed as part of multi-omics characterization. (PMID:41891974)
  • A multidimensional diagnostic approach emphasized metabolomics as one layer in translating gut microbiota signals into IBD diagnostics. (PMID:41220286)

Cardiometabolic and Pulmonary Disease

  • In pulmonary arterial hypertension, metabolomics was used in post-hoc analysis of the REHAB-PH trial to capture molecular responses and assess biomarker stability. (PMID:41849831)
  • A 2026 American Heart Association scientific statement highlighted metabolomics among novel models, biomarkers, and tools for cardiovascular risk prediction. (PMID:41669831)
  • A 2026 review on cardiovascular disease described metabolomics as part of multi-omics technological innovation and clinical translation. (PMID:42013055)
  • Precision medicine in steatotic liver disease also identified metabolomics as an advancing omics layer for clinical stratification. (PMID:41912348)

Agriculture, Stress Biology, and Food Fermentation

  • Metabolomics-guided engineering of drought-resilient crops was presented as a way to dissect drought responses and convert metabolomic signatures into predictive biomarkers. (PMID:41662977)
  • Integrative metabolomics and proteomics of heat stress synthesized molecular mechanisms underlying stress adaptation. (PMID:41605375)
  • Multi-omics analysis of mung bean sour liquid used metabolomics alongside metagenomics to study antioxidant biomarker formation during fermentation. (PMID:41830297)

Reproductive, Clinical Sampling, and Toxicology

  • High-throughput untargeted metabolomics profiled frozen-thawed bull sperm and identified fertility-associated biomarkers distinguishing high and low fertility. (PMID:41091798)
  • Dried blood spot extraction enabled metabolomics and proteomics profiling for clinical trial biomarker discovery. (PMID:41975197)
  • An orthogonal extraction workflow preserved metabolomic compatibility from low microliter-scale plasma samples, supporting high-depth plasma proteomics. (PMID:41944463)
  • In forensic toxicology, metabolomics was discussed as a novel marker approach in the context of machine learning applications and new psychoactive substances. (PMID:41692004)

Cancer and Multi-omics Integration

  • Metabolomics was one of the omics layers integrated in multi-omics frameworks for tumor immunotherapy analysis. (PMID:41938619)
  • A review on breast cancer management highlighted metabolomics within multi-omics and artificial intelligence workflows. (PMID:41936855)
  • Prostate cancer and esophageal squamous cell carcinoma reviews also included metabolomics as part of broader multi-omics biomarker discovery efforts. (PMID:41894385) (PMID:42028731)