DNA methylation

Byaibio

DNA methylation is an epigenomic analysis modality that captures methylation-based regulation of gene expression and tissue function, and it is frequently used as one layer in multi-omics studies. It is implicated across chronic inflammation, steroid resistance, and disease progression, with the provided evidence noting dysregulated histone/protein acetylation and other post-translational modifications alongside dna methylation-related changes. In disease research, it is used in pancreatic cancer, circadian rhythm genes, cardiovascular disease, perioperative neurocognitive disorders, aging, COPD, colorectal cancer susceptibility, and multi-omics survival prediction. Recent studies also highlight DNA methylation-based aging clocks, global disruption associated with IDH mutation, and its role as a mediator of PM2.5 exposure effects on cognitive function. Key facts emphasize that it functions as an epigenomic analysis modality and is part of broader dysregulated epigenetic programs in chronic inflammation and disease progression.

Cancer

  • In pancreatic cancer, DNA methylation dysregulation was examined for mechanistic roles in tumorigenesis and for biomarker/therapy applications. (PMID:41879036)
  • A 2026 Current Drug Targets study linked genetic variation to colorectal cancer susceptibility through mQTL-informed DNA methylation alterations. (PMID:41930642)
  • A 2026 JCI Insight paper reported global disruption of DNA methylation in IDH gain-of-function mutant melanoma, associated with poor immunotherapy response and loss of tumor-infiltrating lymphocytes. (PMID:41955022)
  • A 2026 Journal of Proteome Research multiomics study in African and Middle Eastern prostate cancer patients explicitly included DNA methylation as one of the multiomics layers. (PMID:41894385)

Aging, lifestyle, and epigenetic clocks

  • DNA methylation-based aging clocks were used to assess cross-sectional and longitudinal associations with lifestyle factors in the Singapore diet and healthy aging cohort. (PMID:41763011)
  • In a 2026 Clinical Epigenetics study, DNA methylation helped characterize skin biological aging and its impact on gene expression and tissue function. (PMID:41957838)
  • A population-based study in Psychoneuroendocrinology used DNA methylation aging measures to test whether religiosity and spiritual practices were associated with slower biological aging. (PMID:41713365)

Neurology and environmental exposure

  • A 2026 Environmental Science & Technology study found that short-term PM2.5 exposure impaired cognitive function and altered DNA methylation signatures of circadian rhythm genes. (PMID:41979129)
  • DNA methylation was discussed as part of the epigenetic architecture influencing perioperative neurocognitive disorders in a 2026 British Journal of Anaesthesia review. (PMID:41620312)
  • In COPD multi-omics biomarker detection, DNA methylation was included among the epigenomic features analyzed in smoking-induced disease. (PMID:41605376)

Cardiovascular and multi-omics regulation

  • A 2026 Epigenomics review described DNA methylation as one of the three major layers involved in cardiovascular disease progression and traditional Chinese medicine-mediated regulation. (PMID:41906543)
  • The same cardiovascular framework linked TCM interventions to regulation of DNA methylation, supporting its role as a therapeutic epigenetic target. (PMID:41906543)
  • A multi-task adaptive deep sparse canonical correlation analysis framework used DNA methylation as one of two omics inputs for cancer survival prediction. (PMID:41973703)
  • A 2026 review on multi-omics beyond PSA screening explicitly named DNA methylation as one of the multiomics layers in prostate cancer analysis. (PMID:41894385)