Bovine serum albumin (BSA)-induced allergy is an experimental disease model used to study allergic responses triggered by bovine serum albumin. It appears to function as a platform for identifying active metabolites and diagnostic biomarkers, with multi-omics analysis showing 61 differential metabolites validated in plasma. The model is linked to perturbation of the complement and coagulation cascades, including f10, f2, and plg, suggesting involvement of hemostatic and inflammatory pathways. Diagnostic performance was highlighted for glutamylphenylalanine and hippuraldehyde sulphate, both reported to show excellent sensitivity and accuracy. Overall, this model is mainly used in biomarker discovery and mechanistic allergy research rather than as a therapeutic entity. A 2026 Journal of Pharmaceutical and Biomedical Analysis study (PMID:41385805) integrated multi-omics and network pharmacology to define these regulatory metabolites.
Allergy / Biomarker discovery
- BSA-induced allergy was used as an experimental model to identify active metabolites and diagnostic biomarkers. (PMID:41385805)
- Multi-omics analysis validated 61 differential metabolites in plasma, supporting its use for metabolic profiling in allergy. (PMID:41385805)
- Glutamylphenylalanine showed excellent sensitivity and accuracy for diagnosing BSA-induced allergy. (PMID:41385805)
- Hippuraldehyde sulphate also showed excellent sensitivity and accuracy for diagnosing BSA-induced allergy. (PMID:41385805)
Complement and coagulation pathway
- f10 was identified in the complement and coagulation cascades pathway affected in BSA-induced allergy. (PMID:41385805)
- f2 was identified in the complement and coagulation cascades pathway affected in BSA-induced allergy. (PMID:41385805)
- plg was identified in the complement and coagulation cascades pathway affected in BSA-induced allergy. (PMID:41385805)
- Network pharmacology linked these pathway changes to the regulatory role of active metabolites in the allergy model. (PMID:41385805)