📅 2026년 6월 7일 | PubMed 수집 논문
★ 주요 논문 — 이번 수집의 하이라이트
Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis.
Osteoarthritis (OA) is characterized by chronic inflammation, cellular senescence, and progressive cartilage remodeling, yet effective disease-modifying therapeutic targets remain limited. Caspase-8 has classically been regarded as a key initiator of the extrinsic apoptotic pathway; however, accumul…
DN203316, a novel PPARδ agonist, suppresses ferroptotic signaling and fibrogenesis in metabolic dysfunction-associated steatohepatitis.
Recently, ferroptosis has emerged as a pathogenic mechanism that drives metabolic dysfunction-associated steatohepatitis (MASH); however, the upstream triggers and their relevance to fibrosis remain poorly understood. Here we identified dietary cholesterol-induced ferroptosis and the downregulation …
The translation landscape of ovarian clear cell carcinoma indicates that RBM4 plays a pro-oncogenic role in tumor progression.
Ovarian clear cell carcinoma (OCCC) is a highly aggressive gynecological malignancy characterized by distinct clinicopathological features and resistance to chemotherapy. Despite advances in multi-omics characterization, the translational regulatory landscape of OCCC remains unexplored. Here, we per…
Monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in KRAS-mutant non-small cell lung cancer.
We identified an important oncogenic role for protocadherin 7 (PCDH7), a cell surface protein frequently overexpressed in lung adenocarcinoma and associated with poor clinical outcome. Pcdh7 depletion reduces tumor burden and prolongs survival in KrasLSL-G12D; Tp53fl/fl mice. These findings nominate…
Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis.
Osteoporosis (OP) is increasingly recognised as a disorder driven by impaired lineage allocation of bone marrow stromal cells (BMSCs), characterised by a shift from osteogenesis toward adipogenesis under conditions such as oestrogen deficiency and oxidative stress. Although gut microbiota‑der…
Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.
Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, our unbiased bioinformatics analyses found …
Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers.
ARID1A (AT-rich interaction domain 1A), a key subunit of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, is frequently mutated in cancers. However, effective clinical treatments for patients with this mutation are limited, highlighting a need for therapeutic strategies. He…
HM568 Enhances NAD+ Biosynthesis to Ameliorate Mitochondrial Dysfunction and Neurotoxicity in Parkinson’s Disease Models: A Putative Link to PARP1 Modulation.
Parkinson’s disease (PD) is closely associated with PARP1 overactivation. Although our previously developed compound HM568 has been shown to alleviate PD pathology, its mechanism of action remained unknown. In this study, we show that HM568 significantly improves behavioral deficits, prevents the lo…
Silk-Based Protein Corona Enhances mRNA-LNP Vaccine Efficacy and Prevents Tumor Relapse.
Lipid nanoparticles (LNPs) are clinically validated carriers for nucleic acid therapeutics; however, achieving targeted delivery to reticuloendothelial organs beyond the liver, lung, and spleen remains a major challenge. Here, we introduce a strategy for post-fabrication engineering of a custom prot…
Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity.
Chimeric antigen receptor (CAR) T cell therapy faces many challenges against solid tumors including T cell exhaustion and poor CAR durability. Here, we show that engaging the CAR T cell endogenous T cell receptor (TCR) using an oncolytic virus enhances CAR T cell functionality, durability, and thera…
토픽별 전체 논문
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Multi-omics and experimental evidence in human chondrocytes identify caspase-8 as a non-apoptotic regulator of inflammatory, senescent, and fibrotic signaling in osteoarthritis.
Osteoarthritis (OA) is characterized by chronic inflammation, cellular senescence, and progressive cartilage remodeling, yet effective disease-modifying therapeutic targets remain limited. Caspase-8 has classically been regarded as a key initiator of the extrinsic apoptotic pathway; however, accumul…
인간 연골세포와 다중오믹스를 함께 사용해 기전적 근거를 제시한 점이 강점이다. 다만 아직은 질환 표적 발굴 단계로 보이며, 임상적 효용은 추가 검증이 필요하다.
DN203316, a novel PPARδ agonist, suppresses ferroptotic signaling and fibrogenesis in metabolic dysfunction-associated steatohepatitis.
Recently, ferroptosis has emerged as a pathogenic mechanism that drives metabolic dysfunction-associated steatohepatitis (MASH); however, the upstream triggers and their relevance to fibrosis remain poorly understood. Here we identified dietary cholesterol-induced ferroptosis and the downregulation …
인간 간 조직과 동물 모델, 세포 기전을 함께 제시해 MASH 병태생리 이해에 의미가 있다. 다만 임상 효능은 전임상 수준이며, 실제 치료제로 가려면 추가 독성·약동학·임상 검증이 필요하다.
The translation landscape of ovarian clear cell carcinoma indicates that RBM4 plays a pro-oncogenic role in tumor progression.
Ovarian clear cell carcinoma (OCCC) is a highly aggressive gynecological malignancy characterized by distinct clinicopathological features and resistance to chemotherapy. Despite advances in multi-omics characterization, the translational regulatory landscape of OCCC remains unexplored. Here, we per…
임상 검체를 사용한 전이성 연구로 인간 관련성은 있으나 아직 치료 효과를 보여주는 임상 근거는 아니다. 번역 조절과 미세펩타이드 후보를 제시해 발견 가치는 높다. 다만 상용화로 이어지려면 추가 검증과 기능/약물화 연구가 필요하다.
Monoclonal antibodies targeting PCDH7 inhibit tumor growth and enhance immune responses in KRAS-mutant non-small cell lung cancer.
We identified an important oncogenic role for protocadherin 7 (PCDH7), a cell surface protein frequently overexpressed in lung adenocarcinoma and associated with poor clinical outcome. Pcdh7 depletion reduces tumor burden and prolongs survival in KrasLSL-G12D; Tp53fl/fl mice. These findings nominate…
임상 근거는 아직 전임상 수준이므로 Clinical 점수는 낮다. 그러나 새로운 표적 PCDH7와 항체 치료 전략을 제시해 Discovery 가치는 매우 높다. 상용화는 가능성이 있으나 추가 독성, 약효, 제조 및 임상 검증이 필요하다.
Differential metabolomic prediction of outcomes in HFpEF and HFrEF: a prospective international multi-ethnic cohort study.
Metabolic dysregulation accompanies heart failure (HF), yet coordinated biochemical shifts are rarely quantified for prognostication. We investigated whether early metabolic profiles predict morbidity and mortality in HF with preserved (HFpEF) or reduced ejection fraction (HFrEF)….
Integrated Depression Care and Livelihood Interventions for Low-Income Women in Vietnam: Protocol for a Cluster Nonrandomized Controlled Trial (LIFE-DM).
In Vietnam, economically disadvantaged women face compounded risks due to gender inequality, financial instability, and limited access to mental health care. Community health stations (CHSs), the frontline entry point into the health system and the most accessible primary care facilities, typically …
Optimal blood pressure target in patients with uncomplicated hypertension: a target trial emulation study.
The limited real-world evidence on the clinical benefits of intensive blood pressure (BP) management demonstrated in randomised controlled trials has led to its poor adoption in primary care settings. Here we conducted a target trial emulation study on 118,271 patients with uncomplicated hypertensio…
From Multiomics Discovery to Clinical Validation: Identification of Novel Noninvasive Biomarkers for Liver Fibrosis.
Early diagnosis of liver fibrosis is vital for preventing cirrhosis. Through integrated multiomics and single-cell sequencing, we identified Thrombospondin 2 (THBS2), Growth Differentiation Factor 15 (GDF15), and Neurofascin (NFASC) as prioritized biomarkers, exhibiting prominent expression in fibro…
Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis.
Osteoporosis (OP) is increasingly recognised as a disorder driven by impaired lineage allocation of bone marrow stromal cells (BMSCs), characterised by a shift from osteogenesis toward adipogenesis under conditions such as oestrogen deficiency and oxidative stress. Although gut microbiota‑der…
마이크로바이옴 유래 대사산물이 골다공증을 조절할 수 있음을 보여준 연구다. 동물 및 세포 수준 근거는 강하지만 인간 임상 근거는 없어 임상 영향은 제한적이다. 기전의 새로움과 치료 후보 가능성은 있어 추적 가치는 있다.
Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors.
Histone deacetylase inhibitors (HDIs) are approved for treating hematologic cancers and are currently being evaluated in hundreds of clinical trials for various cancers and other diseases, although their mechanisms of action remain poorly understood. Here, our unbiased bioinformatics analyses found …
이 연구는 HDAC 억제제의 작용기전을 재해석하게 만드는 전임상 결과를 제시한다. 임상적 직접성은 낮지만, 약물 설계와 기전 연구 측면에서는 의미가 크다. 상업적으로는 후속 후보물질 개발 가능성을 열지만 아직 초기 단계다.
Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A-mutated cancers.
ARID1A (AT-rich interaction domain 1A), a key subunit of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, is frequently mutated in cancers. However, effective clinical treatments for patients with this mutation are limited, highlighting a need for therapeutic strategies. He…
전임상 연구로서 임상적 근거는 아직 제한적이다. 그러나 ARID1A 변이 암에서 WRN이 표적 취약점임을 제시해 발견 가치가 높다. 상용화 측면에서는 추가 검증과 약물 개발이 필요하다.
HM568 Enhances NAD+ Biosynthesis to Ameliorate Mitochondrial Dysfunction and Neurotoxicity in Parkinson’s Disease Models: A Putative Link to PARP1 Modulation.
Parkinson’s disease (PD) is closely associated with PARP1 overactivation. Although our previously developed compound HM568 has been shown to alleviate PD pathology, its mechanism of action remained unknown. In this study, we show that HM568 significantly improves behavioral deficits, prevents the lo…
이 연구는 파킨슨병 동물 및 세포 모델에서 HM568의 보호 효과와 작용기전을 제시한 전임상 연구다. 임상 근거는 없으므로 임상 영향은 낮지만, PARP1-NAD+ 축을 겨냥한 새로운 기전 제안은 의미가 있다. 다만 실제 치료제로의 전환에는 추가 검증이 많이 필요하다.
Silk-Based Protein Corona Enhances mRNA-LNP Vaccine Efficacy and Prevents Tumor Relapse.
Lipid nanoparticles (LNPs) are clinically validated carriers for nucleic acid therapeutics; however, achieving targeted delivery to reticuloendothelial organs beyond the liver, lung, and spleen remains a major challenge. Here, we introduce a strategy for post-fabrication engineering of a custom prot…
이 연구는 mRNA-LNP의 표면을 실크 피브로인으로 개량해 전달성과 면역반응을 높인 전임상 결과다. 임상 근거는 없지만 플랫폼 확장성은 크고, 백신 및 mRNA 치료제 개발 측면에서 의미가 있다.
Identification of Patient Clusters with Distinct Disease Progression Patterns Utilizing a Nationwide Finnish Population with Type 2 Diabetes.
Variability in the clinical presentation of patients with type 2 diabetes (T2D) is high and underlines the need for more personalized patient care. This nationwide study aimed to describe characteristics, treatment patterns, and disease progression of Finnish patients with T2D (N = 302…
The value of proteinuria for the administration of rituximab in patients with PLA2R-associated membranous nephropathy: a single-centre retrospective analysis.
Studies have shown that the efficacy of rituximab (RTX) in patients with M-type phospholipase A2 receptor (PLA2R)-associated primary membranous nephropathy (PMN) is related to proteinuria. However, definitive evidence to guide the initiation of RTX therapy based on proteinuria excretion levels in PM…
Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity.
Chimeric antigen receptor (CAR) T cell therapy faces many challenges against solid tumors including T cell exhaustion and poor CAR durability. Here, we show that engaging the CAR T cell endogenous T cell receptor (TCR) using an oncolytic virus enhances CAR T cell functionality, durability, and thera…
이 연구는 CAR T 세포의 기능과 지속성을 높일 수 있는 새로운 병용 전략을 제시한다. 다만 아직 전임상 단계이므로 임상적 의미는 제한적이다. 플랫폼 개념은 흥미롭고 후속 검증 가치가 높다.
First-person perspective gesture observation in virtual reality: A novel approach for anomia rehabilitation in post-stroke aphasia.
According to the embodied cognition framework, language is closely linked to the motor system and rehabilitation programs should stimulate language processing through the activation of motor and perceptual systems. In this study, we present an innovative training program based on the embodied cognit…
Neural network disruptions and their impact on emotion regulation and executive functioning in children treated for brain tumors.
The interplay between emotion and cognition is essential for understanding behavior and mental health. Emotional and cognitive processes are linked through neural circuits, with brain networks such as the limbic system, default mode network, and executive control network modulating emotional respons…
Mimicking the human stratum corneum barrier: a biomimetic brick-and-mortar model forin vitropermeation study.
The development of reliablein vitromodels for stratum corneum (SC) permeation studies remains a significant challenge. Ethical constraints, interspecies disparities, and inter-individual variability in skin underscore the need for standardized skin equivalents with significant research and commercia…
Comparative Effectiveness of mRNA-1273 Versus Protein-Based NVX-CoV2705 Vaccination on COVID-19-Related Outcomes Among Insured Adults in the United States During 2024-2025: A Retrospective Matched Cohort Study.
COVID-19 vaccination with updated compositions remains important as SARS-CoV-2 continues to circulate, cause disease, and evolve. Available COVID-19 vaccines in the 2024-2025 season differed by platform, including mRNA-1273, an mRNA-based vaccine, and NVX-CoV2705, a recombinant protein-based vaccine…
Obstructive Sleep Apnea Associated with Periodontitis: Evidence from Mendelian Randomization and Salivary Proteomics.
Clinical evidence supports a link between obstructive sleep apnea (OSA) and periodontitis. However, whether OSA exerts a causal effect on periodontitis and the underlying protein biomarkers remains unclear. This study aimed to investigate their causal relationship and to identify salivary protein ma…
Inclisiran for LDL-C reduction in secondary prevention: Real-world evidence from a homogeneous Spanish cohort with subgroup insights.
Inclisiran produces sustained LDL-C lowering in clinical trials. Real-world evidence in homogeneous secondary prevention populations is limited….
Real-World Treatment Switch Rates, and Healthcare Costs of Botulinum Toxin Type A Among Patients with Cervical Dystonia in the USA: A Retrospective Claims Analysis.
Real-world evidence on comparative treatment patterns and cost is limited for botulinum toxin type A (BoNTA) treatments for cervical dystonia (CD). This study aims to evaluate treatment switch rates, healthcare resource utilization (HCRU), and healthcare costs among patients with cervical dysto…
Integrated left ventricular multi-omics landscape of human cardiometabolic HFpEF.
Heart failure with preserved ejection fraction (HFpEF), now the leading form of heart failure, is burdened by high morbidity and mortality, owing to gaps in our understanding of its molecular and pathophysiological mechanisms. The obese/cardiometabolic HFpEF phenotype is particularly prevalent and m…
Protoporphyrin IX-loaded solid lipid nanoparticles for dual-wavelength photodynamic therapy of melanoma.
Lipid nanoparticles have emerged as promising nanocarriers for improving the delivery of both hydrophobic and hydrophilic photosensitizers and enhancing therapeutic efficacy in photodynamic therapy (PDT). In this study, a biocompatible PDT agent was developed by encapsulating the hydrophobic photose…
Impact of CKD on perioperative outcomes following TURBT: a national NSQIP analysis.
Transurethral resection of bladder tumor (TURBT) is fundamental to the diagnosis and management of bladder cancer and is generally regarded as a low-risk procedure. However, chronic kidney disease (CKD) is common in this population and may increase perioperative morbidity. The impact of baseline ren…
Ubiquitination-anchored signature defines neuroendocrine prostate cancer: hub genes and single-cell ecosystem insights from integrated bioinformatics analysis of public transcriptomic datasets.
Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC lineage plasticity and that integrating bulk and single-cell transcriptomes would define a…
Neoplastic CD3⁺ B cells remodel the DLBCL tumor microenvironment via single-cell and spatial transcriptomics.
This study constructs a high-resolution multi-omics map of Diffuse Large B-Cell Lymphoma (DLBCL) by integrating single-cell, single-nucleus, and spatial transcriptomics….
Network pharmacology identifies repurposable drugs targeting host pathways across the oral-gut-lung axis.
The systematic integration of heterogeneous host-pathogen interaction data with disease modules and pharmacological knowledge remains a major challenge in translational biomedical informatics. Network medicine offers a promising strategy for identifying conserved regulatory vulnerabilities and thera…
Protective mechanism of nicorandil on myocardial ischemia-reperfusion injury: a multi-omics study highlighting CYP4F5 as a key node.
Nicorandil, a vasodilator, exhibits potential in improving myocardial blood supply, but its protective mechanism against myocardial ischemia-reperfusion (I/R) injury remains unclear. This study aims to explore the cardioprotective effects of nicorandil on myocardial I/R injury and elucidate its mole…
Anti-obesity mechanisms of adzuki bean saponin: a multi-omics and experimental study.
Adzuki bean saponin (ABS) has shown therapeutic potential in improving obesity, but its underlying mechanism and active saponin components are still unknown. This research estimated the anti-obesity effect of ABS in obesity using a mouse model. Advanced research methods such as spatial metabolomics,…
Metabolism and Excretion of Synthetic Extended Viperin Pathway Deoxydidehydronucleosides in the Sprague-Dawley Rat.
Broad-spectrum viral biomarkers offer a promising approach to distinguishing viral from bacterial infections, thereby reducing inappropriate antibiotic use and improving diagnostic response during emerging infectious disease outbreaks. Among these, the deoxydidehydronucleoside (ddhN) class of nucleo…
Proteomic Profiling Reveals the Synergistic Effects of Astaxanthin and Melatonin on the Inhibition of Cryoinjuries in Ram Sperm.
The present study aimed to investigate the protective effects of astaxanthin (AST) and melatonin (MLT) on ram sperm quality-associated indicators during cryopreservation, and to explore the molecular effects of the two cryoprotectants on the protein profile of cryopreserved sperm. First, ram sperm w…
Mass spectrometric proteome profiling using a deep spectral library reveals homogenization of right and left atrial proteomes in persistent atrial fibrillation patients.
Pulmonary veins in the left atrium (LA) are well-established as a critical site for the initiation of atrial fibrillation (AF). Emerging evidence suggests that in persistent AF (persAF), AF triggers may extend beyond LA. However, the extent to which AF-associated remodelling involves the right atriu…
Performance of large language models in urological decision support: a guideline-based comparative evaluation in urolithiasis.
Large language models (LLMs) are increasingly investigated for their potential role in guideline-based clinical information support. However, their consistency with subspecialty guidelines, particularly in urolithiasis, remains underexplored. This study aimed to evaluate the performance of four larg…
Recommendations for disclosure of artificial intelligence in scientific writing and publishing: a regional anesthesia and pain medicine modified Delphi study.
The use of artificial intelligence (AI) in the scientific process is advancing at a remarkable speed, thanks to continued innovations in large language models. While AI provides widespread benefits, including editing for fluency and clarity, it also has drawbacks, including fabricated content, perpe…
An Expert Consensus-Based Review of Considerations for Developing a Quality Management System Framework for Studies Utilising Secondary Data for Real-World Evidence Generation.
High-quality pharmacoepidemiological research is essential for credible real-world evidence (RWE). This expert consensus-based review explores how pharmaceutical Quality Management Systems (QMS) developed for studies using primary data collection (e.g., clinical trials, registries) can be adapted to…
GFPT2 upregulation predicts poor prognosis and is associated with TGF-β/Smad activation in lung adenocarcinoma.
Glutamine-fructose-6-phosphate amidotransferase 2 (GFPT2) is a rate-limiting enzyme of the hexosamine biosynthetic pathway, but its protein-level expression and functional relevance in lung adenocarcinoma (LUAD) remain unclear….
Obesity, Liver Disease, and the Patient Voice: A Clinical Dialogue Podcast.
Obesity is a chronic, progressive disease defined by excess adiposity that can negatively affect a person’s health. Approximately one billion people are living with obesity globally, though this estimate is shaped by the ongoing evolution in how the condition is measured and diagnosed. Although…