📅 2026년 6월 5일 | PubMed 수집 논문
★ 주요 논문 — 이번 수집의 하이라이트
Continuous glucose monitoring versus self-monitoring of blood glucose in individuals with type 2 diabetes: a randomised, multicentre, open-label, superiority trial.
Type 2 diabetes is the most common metabolic disorder worldwide, accounting for about 90% of people living with diabetes. Glycated haemoglobin (HbA1c), a measure of chronic glycaemic exposure, correlates with the risk of long-term complications, which can result in substantial morbidity for people w…
Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models.
Cholangiocarcinoma (CCA) is an adenocarcinoma of the hepatobiliary system that has recently risen in incidence and mortality with unsatisfactory treatment options. Claudin-1 (CLDN1) is a transmembrane protein expressed in tight junctions and exposed on the cell surface in liver fibrosis and cancer. …
Structure-Guided Discovery of a Bis-Pyridyl Diamine-Based Dual CDK7/9 Inhibitor with In Vitro and In Vivo Antitumor Efficacy in Glioblastoma Multiforme.
Glioblastoma multiforme (GBM) is a lethal and fast-growing brain cancer that is difficult to treat with standard medical interventions. GBM tumors often overexpress cyclin-dependent kinase 9, in complex with cyclin T1, and thus, it represents a promising target for therapeutic intervention. In this …
Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation.
Acyl-CoA-binding protein (ACBP, encoded by diazepam binding inhibitor, DBI) is an abundant intracellular regulator of lipid metabolism that also circulates systemically, yet the mechanisms governing its release and its relationship to organ injury remain unresolved. Herein, we combine human multi-om…
IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition.
Tumor-associated macrophages (TAMs) possess both tumor-promoting and tumor-inhibiting roles. Here, we explore TAMs’ anti-tumor functions, focusing on the immune responsive gene 1 (IRG1) and its product, itaconate, in lung cancer development. Spatial metabolomics reveals that endogenous itaconate is …
Efficacy and safety of anagliptin added to metformin and empagliflozin 25 mg in patients with type 2 diabetes: a 24-week randomized, double-blind, placebo-controlled phase 3 trial with 28-week open-label extension.
This study evaluated the efficacy and safety of anagliptin added to metformin and empagliflozin in patients with type 2 diabetes (T2DM) inadequately controlled on dual therapy….
High-resolution spatial multi-omics enables prognostic scoring in intrahepatic cholangiocarcinoma.
Intrahepatic cholangiocarcinoma (iCCA) represents a highly aggressive hepatic malignancy with escalating global incidence and dismal clinical outcomes. Despite therapeutic advancements through targeted therapies and immune checkpoint inhibitors, the field critically lacks robust prognostic tools for…
First-in-human intracisternal dosing of RGX-111 in severe MPS I is well tolerated and generates sustained neurodevelopment without HSCT.
Mucopolysaccharidosis type I (MPS I), caused by α-L-iduronidase enzyme (IDUA) deficiency, manifests multisystemic symptoms from tissue accumulation of undegraded glycosaminoglycans. Severe MPS I (Hurler syndrome) is associated with developmental delay and loss of neurocognition. Although IDUA …
Lactate-induced miR-7-5p/TRIM33 reprograms metabolic flux to suppress tumor growth and viral reactivation.
Cancer metabolic reprogramming generates a hostile tumor microenvironment (TME) characterized by lactate-driven acidosis, fostering tumor progression. Epstein-Barr virus (EBV), an oncogenic herpesvirus linked to multiple malignancies, thrives under such stress, yet how it interacts with and contribu…
Inhalable lipid nanoparticles for macrophage-specific STING gene editing to ameliorate pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease with limited therapeutic options. The stimulator of interferon genes (STING) signaling pathway, particularly in alveolar macrophages, has been identified as a critical driver of fibrosis. However, achieving efficient and select…
Integrated isothermal shift assay and multi-omics identify melittin as a novel EGFR-targeting peptide to suppress NSCLC.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, highlighting the urgent need for novel therapeutic agents. Melittin (MEL), a bioactive peptide, exhibits potent antitumor activity; however, its clinical translation is limited by an incomplete understanding of i…
Therapeutic bacteria-trained NK cells confer long-term protection against cancer metastasis.
Metastasis causes 90% of cancer-related deaths, yet preventive strategies remain limited. Here, we report that a single dose of therapeutic Salmonella, a prominent anti-tumor bacterial therapy, provides long-lasting protection against metastasis in mice by inducing “trained” Natural Killer (NK) cell…
In Situ Electroactive Bacteria-Activated Nanozyme for Amplifying Chemodynamic Therapy of Solid Tumors.
Nanozymes have attracted considerable attention as chemodynamic therapy (CDT) agents for tumor therapy because of their high catalytic activity. However, their incapable tumor tropism and uncontrollable metabolism interference hinder their further application. Here, a biohybrid system that integrate…
Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNFα NANOBODY® compound.
Ozoralizumab (OZR) is a next-generation TNF inhibitor composed of two identical humanized anti-TNFα NANOBODY® molecules (TNF30s) recombinantly linked via one humanized anti-human serum albumin (HSA) NANOBODY® molecule (ALB8) and two peptide linkers. OZR is designed as a unique format…
A combination therapy strategy: precision co-targeting of CCR7 and JAK1 with a smart hydrogel for inflammatory skin diseases.
Inflammatory skin diseases (ISDs) pose a major global burden, yet current therapies are limited by efficacy, accessibility, and cost, necessitating novel effective treatments. Thus, our study proposes a novel synergistic therapeutic strategy for psoriasis (PSO) and atopic dermatitis (AD) by concurre…
Spatial and temporal single cell multi-omics in mice reveals macrophage-SFRP4+ stroma interactions promoting endometrial regeneration via TNF-α.
Repair and regeneration disorder after endometrial injury is the core cause of endometrial diseases. Using a mouse full-thickness endometrial injury model and human endometrial datasets, we performed time-series single-cell and spatial omics to explore the cellular and molecular dynamics of mouse en…
토픽별 전체 논문
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Continuous glucose monitoring versus self-monitoring of blood glucose in individuals with type 2 diabetes: a randomised, multicentre, open-label, superiority trial.
Type 2 diabetes is the most common metabolic disorder worldwide, accounting for about 90% of people living with diabetes. Glycated haemoglobin (HbA1c), a measure of chronic glycaemic exposure, correlates with the risk of long-term complications, which can result in substantial morbidity for people w…
무작위 다기관 우월성 시험으로 임상적 근거 수준이 높다. 제2형 당뇨에서 CGM의 실제 효용을 직접 검증하므로 진료지침과 시장 모두에 의미가 있다. 다만 초록만으로는 효과 크기와 장기 임상결과가 불명확하다.
Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models.
Cholangiocarcinoma (CCA) is an adenocarcinoma of the hepatobiliary system that has recently risen in incidence and mortality with unsatisfactory treatment options. Claudin-1 (CLDN1) is a transmembrane protein expressed in tight junctions and exposed on the cell surface in liver fibrosis and cancer. …
환자 유래 조직과 오가노이드, 동물모델을 함께 사용해 CLDN1의 종양 촉진 역할을 설득력 있게 보여준 연구다. 다만 아직 전임상 단계이므로 임상적 파급력은 제한적이며, 실제 치료제로 이어지려면 추가 독성·약효 검증이 필요하다.
Structure-Guided Discovery of a Bis-Pyridyl Diamine-Based Dual CDK7/9 Inhibitor with In Vitro and In Vivo Antitumor Efficacy in Glioblastoma Multiforme.
Glioblastoma multiforme (GBM) is a lethal and fast-growing brain cancer that is difficult to treat with standard medical interventions. GBM tumors often overexpress cyclin-dependent kinase 9, in complex with cyclin T1, and thus, it represents a promising target for therapeutic intervention. In this …
구조기반 스크리닝으로 GBM 후보물질 GNE-3511을 발굴한 전임상 연구다. 세포 및 마우스 모델에서 효능과 생존 연장 효과를 보여 의미가 있으나, 아직 임상 근거는 없다. 상업화 가능성은 있으나 최적화와 독성 검증이 더 필요하다.
Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation.
Acyl-CoA-binding protein (ACBP, encoded by diazepam binding inhibitor, DBI) is an abundant intracellular regulator of lipid metabolism that also circulates systemically, yet the mechanisms governing its release and its relationship to organ injury remain unresolved. Herein, we combine human multi-om…
인간 코호트와 동물·세포 실험을 함께 사용해 ACBP/DBI의 상승 기전을 잘 보여준 연구다. 임상적 즉시성은 제한적이지만, 조직 손상 바이오마커로서의 활용 가능성은 있다. 상업적 가치는 진단 개발 측면에서 중간 수준으로 보인다.
IRG1/itaconate rewires macrophage and lung tumor metabolism through G6PD inhibition.
Tumor-associated macrophages (TAMs) possess both tumor-promoting and tumor-inhibiting roles. Here, we explore TAMs’ anti-tumor functions, focusing on the immune responsive gene 1 (IRG1) and its product, itaconate, in lung cancer development. Spatial metabolomics reveals that endogenous itaconate is …
인간 종양 절편과 인간 데이터가 포함되어 번역 가능성은 있다. 다만 아직 전임상 중심이라 임상 영향은 제한적이다. 기전은 비교적 선명하고 상업적 가능성도 있으나 개발 리스크가 크다.
Efficacy and safety of anagliptin added to metformin and empagliflozin 25 mg in patients with type 2 diabetes: a 24-week randomized, double-blind, placebo-controlled phase 3 trial with 28-week open-label extension.
This study evaluated the efficacy and safety of anagliptin added to metformin and empagliflozin in patients with type 2 diabetes (T2DM) inadequately controlled on dual therapy….
인간 대상 무작위 이중맹검 3상이라 임상적 의미가 크다. 다만 초록만으로는 효과 크기와 안전성 우위가 불명확해 게임체인저 수준으로 보기는 어렵다. 기존 당뇨 치료 조합의 보완 전략으로서 상업적 가능성은 있으나 차별성은 제한적이다.
High-resolution spatial multi-omics enables prognostic scoring in intrahepatic cholangiocarcinoma.
Intrahepatic cholangiocarcinoma (iCCA) represents a highly aggressive hepatic malignancy with escalating global incidence and dismal clinical outcomes. Despite therapeutic advancements through targeted therapies and immune checkpoint inhibitors, the field critically lacks robust prognostic tools for…
인간 환자 코호트에서 예후 점수를 검증한 점이 강점이다. 다만 아직 치료 성과를 직접 바꾸는 임상시험 결과는 아니므로 임상 영향은 제한적이다. 공간 다중오믹스 기반의 정교한 바이오마커로서 연구·사업적 가치는 충분하다.
First-in-human intracisternal dosing of RGX-111 in severe MPS I is well tolerated and generates sustained neurodevelopment without HSCT.
Mucopolysaccharidosis type I (MPS I), caused by α-L-iduronidase enzyme (IDUA) deficiency, manifests multisystemic symptoms from tissue accumulation of undegraded glycosaminoglycans. Severe MPS I (Hurler syndrome) is associated with developmental delay and loss of neurocognition. Although IDUA …
단일 환자 사례이지만 5년 이상 추적된 점이 강점이다. 안전성과 신경발달 유지가 확인되어 임상적 신호는 있으나, 아직 일반화하기에는 근거가 부족하다. CNS 표적 유전자치료의 가능성을 보여주는 탐색적 결과로 보는 것이 적절하다.
Lactate-induced miR-7-5p/TRIM33 reprograms metabolic flux to suppress tumor growth and viral reactivation.
Cancer metabolic reprogramming generates a hostile tumor microenvironment (TME) characterized by lactate-driven acidosis, fostering tumor progression. Epstein-Barr virus (EBV), an oncogenic herpesvirus linked to multiple malignancies, thrives under such stress, yet how it interacts with and contribu…
인간 검체 기반 바이오마커 제시가 있어 임상적 관련성은 제한적이지만 의미가 있다. TRIM33의 새로운 역할과 대사-바이러스-종양 연결은 발견 가치가 높다. 다만 전임상 중심이라 상업적 가치는 아직 초기 단계다.
Inhalable lipid nanoparticles for macrophage-specific STING gene editing to ameliorate pulmonary fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease with limited therapeutic options. The stimulator of interferon genes (STING) signaling pathway, particularly in alveolar macrophages, has been identified as a critical driver of fibrosis. However, achieving efficient and select…
마우스 폐섬유화 모델에서 대식세포 표적 흡입형 LNP로 STING 유전자를 편집해 치료 효과를 보인 전임상 연구다. 임상 근거는 아직 없지만 전달 플랫폼의 혁신성과 질환 관련성이 높아 후속 개발 가치가 있다.
Integrated isothermal shift assay and multi-omics identify melittin as a novel EGFR-targeting peptide to suppress NSCLC.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, highlighting the urgent need for novel therapeutic agents. Melittin (MEL), a bioactive peptide, exhibits potent antitumor activity; however, its clinical translation is limited by an incomplete understanding of i…
이 연구는 멜리틴의 표적을 EGFR로 제시하며 NSCLC 억제 기전을 설명한 전임상 연구다. 임상 근거는 없지만 표적 규명 측면의 새로움이 있어 추적 가치는 있다. 다만 실제 치료제로 가기까지는 독성, 전달, 효능 검증이 더 필요하다.
Therapeutic bacteria-trained NK cells confer long-term protection against cancer metastasis.
Metastasis causes 90% of cancer-related deaths, yet preventive strategies remain limited. Here, we report that a single dose of therapeutic Salmonella, a prominent anti-tumor bacterial therapy, provides long-lasting protection against metastasis in mice by inducing “trained” Natural Killer (NK) cell…
마우스 기반 전임상 연구로 임상적 근거는 제한적이다. 그러나 NK 세포 훈련이라는 기전이 비교적 명확하고 전이 억제 효과도 커서 발견 가치가 높다. 다만 사람 적용까지는 안전성, 재현성, 전달 방식 검증이 필요하다.
Plasma and intrapulmonary pharmacokinetics of ceftibuten and ledaborbactam in healthy male and female adults.
Ledaborbactam etzadroxil (LED-E) is an oral prodrug of ledaborbactam, a broad-spectrum β-lactamase inhibitor. In combination with ceftibuten (CTB), a third-generation oral cephalosporin, LED-E represents a potential oral β-lactam/β-lactamase inhibitor regimen for treating infection…
In Situ Electroactive Bacteria-Activated Nanozyme for Amplifying Chemodynamic Therapy of Solid Tumors.
Nanozymes have attracted considerable attention as chemodynamic therapy (CDT) agents for tumor therapy because of their high catalytic activity. However, their incapable tumor tropism and uncontrollable metabolism interference hinder their further application. Here, a biohybrid system that integrate…
전임상 수준의 종양 치료 전략으로, 살아있는 세균과 나노자임을 결합한 점이 독창적이다. 다만 인간 임상 근거는 없고 안전성·면역반응·제조 재현성 검증이 필요하다. 상업성은 잠재력이 있으나 개발 리스크가 큰 편이다.
Metabolic Bariatric Surgery Versus Medical Therapy for Type 2 Diabetes: A 5-Year Real-World Cost and Remission Analysis.
Obesity-associated Type 2 Diabetes Mellitus (T2DM) represents a major and escalating driver of healthcare expenditure in Malaysia. Metabolic bariatric surgery (MBS) offers superior glycaemic outcomes compared with medical therapy, but real-world evidence on direct diabetic medication cost savings in…
Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNFα NANOBODY® compound.
Ozoralizumab (OZR) is a next-generation TNF inhibitor composed of two identical humanized anti-TNFα NANOBODY® molecules (TNF30s) recombinantly linked via one humanized anti-human serum albumin (HSA) NANOBODY® molecule (ALB8) and two peptide linkers. OZR is designed as a unique format…
임상 근거를 직접 제시하는 논문은 아니고 구조·기전 중심 연구다. 다만 기존 TNF 억제제와 다른 결합 양식을 규명해 후속 항체 설계에 의미가 있다. 상업적으로는 ozoralizumab의 차별성과 플랫폼 확장 가능성을 뒷받침한다.
Non-exercise estimated cardiorespiratory fitness and incident diabetes in middle-aged and older adults: a cross-cultural comparative cohort study using data from CHARLS and ELSA.
The cross-cultural association between non-exercise estimated cardiorespiratory fitness (eCRF) and incident diabetes remains unclear. We investigated this association and its modifiers in Chinese and British middle-aged and older adults….
A combination therapy strategy: precision co-targeting of CCR7 and JAK1 with a smart hydrogel for inflammatory skin diseases.
Inflammatory skin diseases (ISDs) pose a major global burden, yet current therapies are limited by efficacy, accessibility, and cost, necessitating novel effective treatments. Thus, our study proposes a novel synergistic therapeutic strategy for psoriasis (PSO) and atopic dermatitis (AD) by concurre…
전임상 단계의 피부염 치료 전략으로, 두 표적을 동시에 억제하는 점이 강점이다. 인간 임상 근거는 없지만 기전 검증과 동물 효능이 비교적 탄탄해 추적 가치가 있다.
Cost-Effectiveness of NT-proBNP-Guided Cardiovascular Screening in Chinese Adults With Type 2 Diabetes: Real-World Evidence From the Hong Kong Diabetes Biobank.
Heart failure (HF) is among the most costly and prevalent complications of type 2 diabetes (T2D), with annual incremental healthcare costs reaching US$12800 in Hong Kong. We evaluated the cost-effectiveness of NT-proBNP-guided cardiovascular risk stratification to guide cardioprotective treatment….
Adhesive polyethylene glycol hydrogels with metformin enabling in-situ drug delivery reprogramming immuno-metabolism for tissue repair in diabetic foot ulcers.
Diabetic foot ulcer (DFU) is characterized by persistent inflammation, metabolic dysfunction, and impaired angiogenesis, leading to refractory chronic wounds. Here, we report an adhesive, metformin-loaded (1.0 mM) polyethylene glycol (PEG) based hydrogel (i.e., PEG/Met), constructed from equal volum…
Obstructive sleep apnoea is associated with accelerated progression of diabetic kidney disease.
Persons with type 2 diabetes and diabetic kidney disease (DKD) are at high risk of end-stage kidney disease or death. We investigated the possible contribution of obstructive sleep apnoea (OSA) to decline in kidney function and renal outcomes….
Profiling of extracellular vesicles from primary hepatocytes, organoids, and mash patients identifies cell injury-specific signatures.
Metabolic Dysfunction-Associated Steatohepatitis (MASH) is a severe form of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), traditionally diagnosed via invasive biopsy, underscoring the need for non-invasive alternatives. This study identifies biologically relevant extracellular ve…
Neurocognition and food cue-related brain reactivity after fiber supplementation within a high-protein, plant-based diet in individuals with overweight and prediabetes: A randomized-controlled trial (the DISTAL-study).
The increasing prevalence of obesity and related diseases, such as type 2 diabetes mellitus (T2DM) and neurocognitive dysfunction, warrants sustainable and effective strategies for treatment and prevention. A healthy diet, containing dietary fibers that are fermented by the gut microbiome, produces …
Impact of sodium-glucose cotransporter-2 inhibitors on clinical outcomes in patients with type 1 diabetes after dialysis-requiring acute kidney injury: a real-world cohort study.
Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) have shown significant cardiovascular and kidney benefits, but their role in T1D with acute kidney disease (AKD) remains uncertain….
Targeted foot muscle strengthening reverses atrophy and reduces plantar peak pressure in diabetic neuropathic feet.
Ulcer formation poses a serious clinical problem and has been associated with muscle function and tissue loss in diabetic feet and increased plantar peak pressures during walking. Reduced intrinsic and extrinsic foot muscle strength has been considered to increase the plantar peak pressure at the mo…
RNF146 enhances olaparib sensitivity in triple-negative breast cancer via XRCC5 downregulation.
To investigate RNF146 expression in triple-negative breast cancer (TNBC) and its role in modulating sensitivity to the PARP inhibitor olaparib, we analyzed RNF146 expression and its association with patient survival using The Cancer Genome Atlas (TCGA) database. Functional studies were performed in …
Am80-lipid nanoparticles serve as an enteric mucosal adjuvant following parenteral immunization with inactivated polio vaccine.
Enteric pathogens are a major contributor to the global disease burden, necessitating vaccines capable of inducing robust gastrointestinal mucosal immunity. Achieving this response is especially challenging with inactivated or subunit vaccines, which lack the ability of live-attenuated formulations …
Melanocortin-4 Receptor Agonist Treatment of Hypothalamic Obesity in ROHHAD Syndrome.
ROHHAD (rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation) syndrome is a rare and complex pediatric condition marked by severe, early-onset hyperphagia and life-threatening obesity. For the past 2 years, we have been treating a boy, now aged 12 …
Dose-Response Associations of Intermittent Lifestyle Physical Activity Micropatterns and Incident Type 2 Diabetes.
To examine dose-response associations of vigorous intermittent lifestyle physical activity (VILPA; bouts ≤1 min) and its moderate- to vigorous-intensity equivalent (MV-ILPA; bouts ≤3 min) with incident type 2 diabetes….
Association between chronic low-grade inflammation and metabolic syndrome and their impact on the risk of coronary artery disease in type 1 diabetes.
Evaluate the interplay between metabolic syndrome (MS) and chronic low-grade inflammation in type 1 diabetes at different stages of diabetic kidney disease, and to assess whether chronic low-grade inflammation, determined by high-sensitivity C-reactive protein (hs-CRP) increases coronary artery dise…
A Remote Chronic Disease Management Program to Improve Cardiovascular and Metabolic Outcomes in a Diverse Community-Based Diabetic Population: Study Design of the TAMIS Trial.
Cardiovascular and cerebrovascular diseases are projected to expand in the coming decades as the main cause of death. This study outlines the escalating burden of cardiovascular diseases in low- and middle-income countries (LMICs), particularly in Latin America (LA), which is expected to surpass tha…
Combination therapy with clinically approved PPARα/δ/γ subtype-selective agonists pemafibrate, seladelpar, and pioglitazone in a 4-week diet-induced early-stage MASLD mouse model.
Numerous treatments for metabolic dysfunction-associated steatohepatitis (MASH) have been developed, but none of them have been clinically approved except for resmetirom and semaglutide. One of the most promising drugs targets peroxisome proliferator-activated receptors α/δ/γ (PPAR…
Alpha-tocopherol intake and status exhibit population-specific associations with metabolic syndrome among two Hispanic/Latinos populations.
Adequate alpha-tocopherol intake and status may reduce the risk of metabolic syndrome (MetS), yet evidence among Hispanics/Latinos remains limited. This study examined population-specific associations of alpha-tocopherol intake and status with MetS in two Hispanic/Latino populations and identified t…
Photobiomodulation therapy for oral mucositis: clinical experience from a supportive care program at the Indian Institute of Head and Neck Oncology.
Photobiomodulation (PBM), the therapeutic use of non-ionizing red to near-infrared light, has emerged as a safe, non-invasive, evidence-based modality for managing oral mucositis (OM) in oncology….
Maternal Hyperglycemia and Adult Offspring Overweight and Obesity: Is Birthweight a Mediator?
We and others have shown that maternal hyperglycemia during pregnancy in women with insulin-dependent diabetes mellitus (IDDM) influences fetal growth. Less is understood regarding how trimester-specific glycemic patterns, particularly glucose variability, shape offspring obesity risk across the lif…
Cost analysis of flap reconstruction for diabetic foot ulcers in the NHS: A single-centre study.
Diabetic foot disease costs NHS England up to £1 billion annually. Flap reconstruction can offer limb salvage in patients with diabetic foot ulcers (DFUs), but its cost-effectiveness remains unclear. This study evaluates the impact of flap reconstruction for DFU on direct secondary health costs…
Spatial and temporal single cell multi-omics in mice reveals macrophage-SFRP4+ stroma interactions promoting endometrial regeneration via TNF-α.
Repair and regeneration disorder after endometrial injury is the core cause of endometrial diseases. Using a mouse full-thickness endometrial injury model and human endometrial datasets, we performed time-series single-cell and spatial omics to explore the cellular and molecular dynamics of mouse en…
마우스 모델 중심의 전임상 연구로 임상적 직접성은 낮다. 그러나 대식세포-TNF-α-SFRP4 축이라는 재생 기전을 제시해 발견 가치가 높다. 상용화 가능성은 있으나 추가 검증과 치료전략 개발이 필요하다.
Real-world outcomes of second-line pembrolizumab in urothelial carcinoma: a multicenter analysis from the Campania Oncological Network (ROC).
Platinum-based chemotherapy followed by second-line immunotherapy has been traditionally the standard of care for locally advanced or metastatic urothelial cancer (La/mUC). However, checkpoint inhibitors are remarkably reshaping the therapeutic landscape for urothelial cancer. Despite these advances…
MAVS is important for antiviral defense against influenza A virus in a human respiratory epithelium model.
The respiratory epithelium is an important immunological barrier and the first line of defense against influenza A virus (IAV). In mice and in various cellular systems, induction of type I interferons (IFNα/β) during IAV infections is known to depend on cytosolic RNA sensors retinoic aci…
Synergistic Chemoimmunotherapy of Hepatocellular Carcinoma via ROS-Responsive Carrier-Free Prodrug Nanoparticles.
Carrier-free nanomedicines, with their high drug-loading capacity and low carrier-associated toxicity, offer a promising strategy for synergistic cancer therapy. Here, we developed a reactive oxygen species (ROS)-responsive, carrier-free nanoparticle (PRO/OCA NP) self-assembled from a resveratrol pr…
GPR75 genetic manipulations in mice reveal central mechanism for weight loss independent of developmental effects.
Human genetic studies have identified GPR75 loss-of-function variants to be strongly protective against obesity, establishing GPR75 as a compelling therapeutic target. However, critical questions remain regarding the translational potential of GPR75 inhibition. These include whether adult-onset inhi…
Natural history of thyroid function in ageing: an individual participant data analysis of 137 488 participants from 31 prospective cohort studies.
Evidence regarding thyroid function changes with ageing remains inconsistent and the implications of potential changes are unclear. We aimed to investigate ageing-related thyroid function changes and their associations with mortality….
A photocleavable peptidic Ru(ii) mass-tag enabling targeted DESI and MALDI mass spectrometry imaging in cancer tissues.
Mass spectrometry imaging (MSI) is a versatile technique for spatially resolved multi-omics analysis in clinical research. However, its proteomic applications remain constrained by issues such as poor ionisation efficiency and signal interference from complex tissue matrices. On-tissue mass-tag labe…
Effects of Semaglutide on Weight and Insulin Requirements in Two Adolescents With Type 1 Diabetes.
We present 2 case reports of the benefits of the subcutaneous once-weekly glucagon-like peptide 1 receptor agonist (GLP-1RA) therapy semaglutide in adolescents with type 1 diabetes (T1D) complicated by obesity. Two female individuals (17 and 12 years old) with T1D who have automated and continu…
Breast cancer in Bosnia and Herzegovina: real-world patterns of diagnosis, treatment, and survival outcomes.
Timely diagnosis is critical for improving breast cancer outcomes, especially in resource-limited health systems. This study provides the first real-world evidence from Bosnia and Herzegovina on diagnostic and treatment intervals, adherence, and survival in women with breast cancer. We conducted a r…
Feasibility of Technology-Assisted Lifestyle Self-Monitoring in Older Adults With Type 2 Diabetes: Mixed Methods Pilot Study.
Type 2 diabetes is a major public health concern in older adults. Healthy lifestyles, such as physical activity and healthy eating, are effective strategies for diabetes self-management. Increasing evidence shows that health technologies can promote healthy lifestyles for diabetes management. Howeve…
Post-marketing safety profile of palivizumab: a 20-year pharmacovigilance study using the FDA Adverse Event Reporting System (FAERS).
Palivizumab is an FDA-approved monoclonal antibody for preventing severe respiratory syncytial virus (RSV) infections in high-risk children. However, its real-world safety profile, particularly beyond clinical trial populations, remains incompletely characterized. This study aimed to systematically …
Coumarin metabolites in Ocimum: chemical diversity, biosynthetic pathways, and network pharmacology-based prediction of multi-target anticancer potential.
Ocimum, a widely used medicinal and culinary herb, is known for its health-promoting properties, yet most research has focused on its volatile oils, leaving the therapeutic potential and biosynthesis of its coumarins largely unexplored. Despite reports of coumarin bioactivity in other plants, a comp…
Development of single chain antibodies for targeting Ewing sarcoma surface marker CD99.
Recombinant antibodies have become an important class of therapeutic agents in cancer treatment. CD99, a transmembrane glycoprotein, is upregulated in several malignancies, including Ewing sarcoma (ES). The current therapy for ES comes with significant toxicity and a substantial risk of life-threate…
Molecular Basis of Thermostability in a Novel Polygalacturonase MlPG28A and Its Application in Producing Bioactive Oligogalacturonides for Sustainable Aquaculture.
A novel thermostable polygalacturonase, MlPG28A, was identified from Mucor lusitanicus and characterized for biochemical properties, structural determinants of thermostability, and potential in the enzymatic production of functional oligogalacturonides (OGs). MlPG28A exhibited exceptional heat toler…
Aromatase inhibitory, anti-proliferative, and apoptosis-inducing effects of naphthoquinone-triazole derivatives for potential anti-breast cancer agents: In vitro and molecular docking studies.
Aromatase enzyme is a rate-limiting enzyme playing a key role in estrogen biosynthesis, and its inhibition has been noted as a strategy for the management of hormone-dependent breast cancers. Naphthoquinone and triazole are attractive pharmacophores due to their wide-ranging bioactivities and unique…
Cyclic tensile stress restores chondrocyte homeostasis via integrin-FAK-RhoA/ROCK2 signaling: A multi-omics study.
The disruption of chondrocyte homeostasis, manifesting as an anabolic/catabolic imbalance and increased apoptosis, is a hallmark of osteoarthritis (OA). While physiological mechanical stimuli are protective, the molecular mechanisms rescuing degenerative chondrocytes remain unclear. This study eluci…
Integrating machine learning and WGCNA to identify core candidate genes and decipher immune-related molecular networks in TcdA/TcdB-associated CDI.
Clostridioides difficile infection (CDI) remains a leading cause of healthcare-associated diarrhea and is characterized by high recurrence rates and inadequate predictive tools despite available therapeutic options. Current toxin- or nucleic acid-based assays do not fully capture host inflammatory d…
Alteration of small intestinal microbiota in diet-induced steatohepatitis mice.
Dysbiosis is an important factor that exacerbate metabolic dysfunction-associated steatohepatitis (MASH) via the gut-liver axis. The alterations in the small intestinal microbiota and their contribution to MASH pathogenesis remain largely unexplored. The present study aimed to clarify the alteration…
The Influence of Social Media Messaging on Human Papillomavirus Vaccine Attitudes and Confidence Among Adolescent Males: Group Discussion Study.
Despite the human papillomavirus (HPV) vaccine being available to males for the past 12 years, adolescent males continue to lag in HPV vaccine uptake due to a variety of factors. With the ubiquitous nature of social media use among this population, further research is needed to improve HPV vaccine c…
Ellagic Acid from Pomegranate Peel Attenuates Fibrosis and Remodels Water Distribution in Chicken Meat under Inflammatory Challenge.
Pomegranate peel (PoP) contains various pharmacologically active compounds, but remains underutilized. This study investigated the efficacy of PoP and its active compounds in alleviating inflammation-induced deterioration of meat quality in broilers. As expected, PoP alleviated inflammation and impr…
The anticancer effects of PCAIs in pancreatic cancer cells involve MAPK and PI3K/AKT pathways hyperactivation.
Copyright: © 2026 Ofosu-Asante et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. There…
Toxicity and risk after using new modalities of radiotherapy in Algeria: retrospective intercomparison study.
This study aims to assess different advanced treatments modalities in terms of their toxicity NTCPs and the induced second primary cancers excess absolute risk (EARs) using in-house software “COUPOLE” in case of prostate cancer. A total of 72 patients (GI, GII, GIII, and GIV) were treated using: VMA…
Dietary Supplementation with N-Acetylcysteine Ameliorates Sleep Deprivation-Induced Ruminal Apoptosis in Tibetan Sheep.
Sleep deprivation (SD) is associated with gastrointestinal dysfunction. However, the mechanisms underlying SD-induced ruminal epithelial apoptosis remain elusive. This study revealed that N-acetylcysteine (NAC), a naturally occurring antioxidant in Allium plants with antioxidant properties, ameliora…
Multi-omics characterization of the skin microbiota reveals the anti-aging roles of Stenotrophomonas maltophilia.
Shifts in the skin microbiome have shown a close link to chronological age. However, the contribution of the skin microbiome in skin-aging phenotypes remains unclear….
Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study.
Understanding heterogeneous responses to glucose-lowering therapies is crucial for advancing personalized treatment and optimizing outcomes in type 2 diabetes mellitus (T2DM). While average treatment effects are established for many drug classes, responses may vary by clinical and demographic factor…
Adult cardiovascular dysfunction induced by peri-pubertal high-fat diet exposure is mediated by the renin-angiotensin axis in male rats.
This study investigated whether the renin-angiotensin system (RAS) is associated with the hypertension and metabolic syndrome induced by high-fat diet exposure during the peri-pubertal phase in rats. At postnatal day (PN) 30, male Wistar rats were randomly selected to be fed a normal diet (NF, 4.5% …
Inhibiting Purinergic Receptor (P2X7R) Alleviates Depression- and Anxiety-Like Behaviors in Obese Rats With Immune Challenge.
Chronic high-fat diet (HFD) consumption combined with lipopolysaccharide (LPS) challenge promotes microglial hyperactivation, brain inflammation, reduced neurogenesis, and depression-like behavior. LPS also increases adenosine triphosphate (ATP) release from immune and dying cells, activating microg…
Two novel indigenous Levilactobacillus brevis probiotic strains MKMB04 and MKMB05 enhance longevity and protect intestinal barrier function through antioxidant and anti-inflammatory mechanisms.
Aging is characterized by progressive oxidative stress, mitochondrial dysfunction, chronic inflammation and intestinal barrier impairment, contributing to increased susceptibility to age-associated disorders. Targeting redox imbalance and epithelial dysfunction represents a promising therapeutic str…
Psychosocial Factors Mediate the Relationship Between Olfactory Function and Cognitive Frailty in Older Adults: A Structural Equation Modelling.
With the trend of population ageing, cognitive frailty in older adults is an increasingly pressing public health iss