📅 2026년 6월 4일 | PubMed 수집 논문
★ 주요 논문 — 이번 수집의 하이라이트
Efficacy and safety of darolutamide in combination with androgen deprivation therapy and docetaxel in European patients from the phase 3 ARASENS trial.
In ARASENS, risk of death was significantly reduced by 32.5% with darolutamide in combination with androgen deprivation therapy (ADT) and docetaxel (hazard ratio [HR], 0.68; 95% confidence interval [CI], 0.57-0.80; p < 0.001) in patients with metastatic hormone-sensitive prostate ca…
Multi-omics integration provides biological insight and prioritizes potential drug targets in multiple sclerosis progression.
Current therapies for multiple sclerosis (MS) primarily reduce relapse rates and delay disability by targeting inflammation, while have limited efficacy against disease progression driven by neurodegenerative processes. We sought to identify and validate proteins for MS progression by integrating a …
Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial.
Despite high recanalization rates with endovascular thrombectomy for acute ischemic stroke due to large vessel occlusion, functional outcomes remain suboptimal. The benefit of adjunctive intra-arterial thrombolysis after successful thrombectomy is uncertain….
Patient-reported outcomes from the LAURA study: osimertinib in patients with unresectable stage III EGFR-mutated non-small cell lung cancer after definitive chemoradiotherapy.
The LAURA study in unresectable stage III EGFR-mutated NSCLC without progression during/after chemoradiotherapy demonstrated significantly improved progression-free survival (PFS) with osimertinib versus placebo after definitive chemoradiotherapy. We report patient-reported outcomes (PROs) from LAUR…
A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response.
Understanding aging and complex diseases requires diverse data, ranging from molecular profiles to imaging and routine clinical tests. However, most multi-omic datasets measure only a subset of modalities and are confounded by batch effects. Here, we present AURORA (AI unification and reconstruction…
Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.
Early-stage drug discovery involves a complex set of processes that typically requires iterative exploration of a vast chemical-biological search space. Over the past few decades, these processes have been facilitated using automated experimentation in the form of high-throughput screening technolog…
ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease.
Coronary microvascular dysfunction (CMD) participates in the pathophysiology of multiple cardiovascular diseases, but treatment options are limited. A new treatment option may include V-erb-b avian erythroblastic viral oncogene homology-type 4 (ERBB4) stimulation by neuregulin-1 (NRG1), which has an…
PDIA6-SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression.
Gastric cancer (GC) remains an aggressive malignancy with limited effective therapeutic options. Integrated single-cell and bulk transcriptomic analyses identify protein disulfide isomerase A6 (PDIA6) as a tumor epithelial-enriched gene associated with advanced tumor‑ node‑metastasis (…
Targeted TNF Potentiates the Activity of Bispecific T-cell Engagers in Solid Tumors by Turning Cold Tumors Hot.
Colorectal cancer remains a major global health burden and an area of urgent unmet medical need. Immunotherapy has shown limited success in colorectal cancer as most patients present with an immune-excluded, “cold” tumor microenvironment (TME). In this study, we report a dual-modality approach to tr…
An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma.
The enhancer lysine acetyltransferases CBP/p300 are compelling targets for multiple myeloma therapy. Chemical inhibition of these multidomain factors, either through the bromodomain or the catalytic acetyltransferase domain, show promising activity in pre-clinical models. Chemical degradation is the…
Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease.
The progression from metabolic dysfunction-associated steatotic liver disease (MASLD) to steatohepatitis (MASH) entails rapid, often irreversible hepatic injury, underscoring the urgent need for innovative therapeutic strategies. Here, we demonstrate that excessive dietary sugar intake, particularly…
Target discrimination and PAM profiling of the Thermotoga maritima type I-B CRISPR system.
Type I-B CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems represent the most abundant CRISPR subtype in nature and have emerged as powerful tools for endogenous genome editing in diverse prokaryotes. Here we reconstitute and characterize the t…
Autophagy-Enhanced Nanoplatforms Eliminate Intracellular Bacteria and Block Bacteria-Driven Epithelial-Mesenchymal Transition for Tumor Metastasis Inhibition.
Tumor intracellular bacteria are a key driving force of epithelial-mesenchymal transition (EMT) in tumor cells, and EMT is a critical process in the metastasis cascade. Eliminating intracellular bacteria is a prospective therapeutic target for metastasis. However, existing targeted antibacterial app…
Lung-Targeted Delivery and Reactive Oxygen Species-Triggered Activation of Pro-protein for Antibacterial Therapy.
Protein therapeutics exhibit unparalleled target specificity but are often compromised by limited spatiotemporal control, leading to off-target effects and reduced in vivo efficacy. Herein, we report a modular chemical approach for the programmable regulation of protein activity via chemical conjuga…
Bispecific Macrophage Nano-Engager Couples Dual Checkpoint Blockade with Stimulator of Interferon Genes Activation to Potentiate Antitumor Immunity.
The immunosuppressive tumor microenvironment, characterized by impaired antigen presentation, “don’t eat me” signaling, and T-cell exhaustion, challenges effective cancer immunotherapy. Conventional T-cell-redirecting bispecific engagers (BiTEs) show limited efficacy in solid tumors because of poor …
GFPT1 as a cross-ancestry validated target for degenerative spinal disease: genetic association in a Chinese cohort and functional characterization in zebrafish.
Degenerative spinal disease (DSD), including spinal stenosis and spondylosis, lacks effective pharmacological treatment. To identify druggable targets and assess cross-ancestry applicability, we integrate multi-omics analyses using Summary-data-based Mendelian Randomization (SMR), colocalization, an…
Injectable Binary-Amplified Cascade Hydrogels Suppress Post-Incomplete Microwave Ablation Relapse via Integrated Metallo-Metabolic-Immunomodulation.
Hepatocellular carcinoma (HCC) relapse following incomplete microwave ablation (iMWA) represents a formidable clinical challenge. This progression is fueled by residual tumor cells that exhibit cell death resistance and dysregulated fatty acid metabolism, while exploiting a myeloid-derived immunosup…
토픽별 전체 논문
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Efficacy and safety of darolutamide in combination with androgen deprivation therapy and docetaxel in European patients from the phase 3 ARASENS trial.
In ARASENS, risk of death was significantly reduced by 32.5% with darolutamide in combination with androgen deprivation therapy (ADT) and docetaxel (hazard ratio [HR], 0.68; 95% confidence interval [CI], 0.57-0.80; p < 0.001) in patients with metastatic hormone-sensitive prostate ca…
ARASENS의 유럽 환자 하위분석으로, 전체 생존 이득이 유지되는지 확인한 임상적으로 중요한 자료다. 다만 새로운 기전이나 치료 패러다임을 제시한 것은 아니므로 발견적 가치는 제한적이다. 상업적으로는 전립선암 표준치료 확산과 처방 확대에 도움이 될 수 있다.
Multi-omics integration provides biological insight and prioritizes potential drug targets in multiple sclerosis progression.
Current therapies for multiple sclerosis (MS) primarily reduce relapse rates and delay disability by targeting inflammation, while have limited efficacy against disease progression driven by neurodegenerative processes. We sought to identify and validate proteins for MS progression by integrating a …
이 연구는 인간 유전체와 단백질 QTL을 통합해 MS 진행 관련 후보 표적을 제시한 점이 의미 있다. 다만 아직은 표적 우선순위화 단계로, 임상적 효용은 후속 검증이 필요하다.
Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial.
Despite high recanalization rates with endovascular thrombectomy for acute ischemic stroke due to large vessel occlusion, functional outcomes remain suboptimal. The benefit of adjunctive intra-arterial thrombolysis after successful thrombectomy is uncertain….
이 연구는 혈전제거술 후 보조적 동맥내 알테플라제를 평가한 무작위 임상시험이다. 임상적으로는 의미가 크지만, 초록만으로는 효과 크기와 안전성의 확정적 우위를 판단하기 어렵다. 상용화 측면에서는 뇌졸중 치료 보조요법으로의 확장 가능성이 있으나 추가 근거가 필요하다.
Patient-reported outcomes from the LAURA study: osimertinib in patients with unresectable stage III EGFR-mutated non-small cell lung cancer after definitive chemoradiotherapy.
The LAURA study in unresectable stage III EGFR-mutated NSCLC without progression during/after chemoradiotherapy demonstrated significantly improved progression-free survival (PFS) with osimertinib versus placebo after definitive chemoradiotherapy. We report patient-reported outcomes (PROs) from LAUR…
LAURA의 후속 PRO 분석으로, 임상적 맥락은 매우 중요하다. 다만 본 초록만으로는 새로운 치료효과 자체보다 환자 경험 보강 자료에 가깝다. 상업적으로는 이미 강한 개발 모멘텀이 있는 약물의 채택 근거를 더해주는 수준이다.
A generative AI framework unifies human multi-omics to model aging, metabolic health, and intervention response.
Understanding aging and complex diseases requires diverse data, ranging from molecular profiles to imaging and routine clinical tests. However, most multi-omic datasets measure only a subset of modalities and are confounded by batch effects. Here, we present AURORA (AI unification and reconstruction…
인간 대규모 멀티오믹스 데이터를 통합하는 방법론적 성과가 크다. 다만 아직은 예측·재구성 중심의 플랫폼으로, 임상적 효용은 추가 검증이 필요하다. 상업적으로는 바이오마커·디지털 헬스 영역에서 가능성이 있으나 개발 리스크가 남아 있다.
Improved Prediction of Invasive Bacterial Infections in Febrile Infants Using Machine Learning.
Existing guidelines for febrile infants aged 8 to 60 days use clinical appearance, age, and laboratory test results to assess the risk of invasive bacterial infections (IBIs) with variable performance. This study aimed to (1) develop and validate 5 supervised learning models (SLMs) capable of p…
Early-stage drug discovery in a new-generation ultrahigh-throughput mass spectrometry platform.
Early-stage drug discovery involves a complex set of processes that typically requires iterative exploration of a vast chemical-biological search space. Over the past few decades, these processes have been facilitated using automated experimentation in the form of high-throughput screening technolog…
이 논문은 초기 약물발굴 공정을 하나의 자동화 플랫폼으로 묶었다는 점이 핵심이다. 임상 근거는 없지만, 합성-분석-생물활성 평가를 빠르게 연결하는 기술적 가치가 크다. 상용화 측면에서는 유망하나 실제 도입까지는 추가 검증이 필요하다.
An open-label, two-cohort, phase 1a/b study of weekly irinotecan hydrochloride liposome injection combined with vincristine and temozolomide (NALIRI-VT) in patients with advanced Ewing sarcoma.
To determine the recommended phase II dose (RP2D), safety, and preliminary efficiency of liposomal irinotecan combined with vincristine and temozolomide (NALIRI-VT) in children and adult with relapsed/refractory Ewing sarcoma….
Toward personalized medicine in childhood nephrotic syndrome.
Childhood idiopathic nephrotic syndrome remains treated empirically despite profound pathophysiological heterogeneity. Tu et al. develop a polygenic risk score incorporating clinical data and human leukocyte antigen class II variants to stratify steroid responsiveness at diagnosis. Although predicti…
ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease.
Coronary microvascular dysfunction (CMD) participates in the pathophysiology of multiple cardiovascular diseases, but treatment options are limited. A new treatment option may include V-erb-b avian erythroblastic viral oncogene homology-type 4 (ERBB4) stimulation by neuregulin-1 (NRG1), which has an…
이 연구는 돼지 대동물 모델에서 미세혈관 기능장애를 개선한 전임상 결과다. 임상 근거는 아직 없지만 번역 가능성은 있어 추적 가치가 있다. 기전이 불명확해 상업적 확신은 제한적이다.
A Z-Score Template Method for Person-Specific Augmentation of Clinical Brain MRI: An Investigation in Multiple Sclerosis.
Clinical MRI is essential for managing neurological disorders such as multiple sclerosis (MS) but often inconsistent, limiting secondary analyses for enhanced information characterization. Our goal was to establish a new Z-score template method for person-specific image augmentation, as compared to …
A Randomized Trial to Investigate the Effects of Low-Dose Colchicine in Patients with Hypertension: Rationale and Design of the COlchicine and HypERtENsion Trial (COHERENT).
Hypertension is a prevalent and significant risk factor for cardiovascular disease (CVD). The immune system and inflammatory response are involved in the pathophysiology of hypertension. We hypothesize that treating hypertension with colchicine on top of standard therapy, will decrease pulse wave ve…
PDIA6-SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression.
Gastric cancer (GC) remains an aggressive malignancy with limited effective therapeutic options. Integrated single-cell and bulk transcriptomic analyses identify protein disulfide isomerase A6 (PDIA6) as a tumor epithelial-enriched gene associated with advanced tumor‑ node‑metastasis (…
위암의 진행 기전을 새롭게 제시한 연구다. 다만 임상 환자 대상 검증은 없어서 임상 영향은 제한적이다. 기전과 동물실험 근거가 탄탄해 후속 연구 가치가 높다.
Fully Automated Quantification of Functional Small Airway Disease at Inspiratory and Expiratory Chest CT Using Deep Learning.
Purpose To evaluate the accuracy and time efficiency of a deep learning (DL)-based tool for automated quantification of functional small airway disease (fSAD) at chest CT compared with a conventional semimanual method. Materials and Methods This retrospective study included paired inspiratory and ex…
Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large-Scale Genomic Analysis of 1094 Patients.
To investigate the prevalence, characteristics, and clinical implications of germline mutations in a consecutive cohort of Chinese colorectal cancer (CRC) patients, providing insights that may inform population-specific genetic testing strategies….
A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics, and pharmacodynamics of OSE-279, an anti-PD-1 monoclonal antibody in patients with advanced solid tumours.
OSE-279 is a high affinity humanized monoclonal bivalent antibody against PD-1 with potent antitumor activity in vivo in syngeneic non-clinical models….
Liver Aging Index: A Noninvasive Score for Liver Biological Aging and Liver-Related Outcomes in Multicohorts.
Biological aging is a key determinant of liver disease and mortality, but there is little evidence on noninvasive index for assessment of liver biological aging. We developed the Liver Aging Index (LAI) in the China Kadoorie Biobank (CKB, N = 21,629) using Cox-Gompertz proportional haz…
Imaging biomarkers as surrogate endpoints for clinical trials on permanent tooth regeneration in congenital tooth agenesis.
Multiple genes are responsible for the absence of teeth at birth, known as congenital tooth agenesis. The humanized anti-USAG-1 antibody, TRG035, was developed for use in molecular-targeted therapy for the regeneration of congenitally absent teeth in patients with congenital tooth agenesis. Detectin…
Numerical Inverse Design of Patient-Specific Dental Implants: Accelerating FEA-Based Optimization via Evolutionary Neural Surrogates.
Mechanical complications in dental implantology often arise from a mismatch between standardized geometries and patient-specific anatomical constraints. While high-fidelity finite element analysis (FEA) is the gold standard for identifying these risks, its high computational cost creates a “bottlene…
Cancer-Associated Fibroblasts in Invasion Front Can be a Prognostic Predictor for Oral Squamous Cell Carcinoma.
Tumor immune microenvironment (TME) is an important pathogenic component in cancer, and a therapeutic target. To examine the role of the TME, especially cancer-associated fibroblasts (CAFs) in oral squamous cell carcinoma (SCC), a retrospective cohort study of 684 patients with surgically resected t…
Nanostructured High-Entropy Yolk-Shell Oxides Platform for Efficient Metabolic Profiling of Diabetic Retinopathy.
Diabetic retinopathy (DR) is a leading cause of blindness in middle-aged and elderly populations worldwide, and its diagnosis remains challenging due to the reliance on subjective interpretation of retinal images by experienced ophthalmologists. Here, we report a nanoenabled metabolomics strategy ba…
Targeted TNF Potentiates the Activity of Bispecific T-cell Engagers in Solid Tumors by Turning Cold Tumors Hot.
Colorectal cancer remains a major global health burden and an area of urgent unmet medical need. Immunotherapy has shown limited success in colorectal cancer as most patients present with an immune-excluded, “cold” tumor microenvironment (TME). In this study, we report a dual-modality approach to tr…
전임상에서 종양 미세환경을 염증성으로 바꾸어 T세포 치료 효과를 높인 점이 핵심이다. 임상 근거는 없으므로 임상 영향은 낮지만, 기전적 새로움과 후속 개발 가치는 있다.
An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma.
The enhancer lysine acetyltransferases CBP/p300 are compelling targets for multiple myeloma therapy. Chemical inhibition of these multidomain factors, either through the bromodomain or the catalytic acetyltransferase domain, show promising activity in pre-clinical models. Chemical degradation is the…
이 연구는 다발골수종에서 CBP/p300 분해 전략의 유효성을 보여주는 전임상 성과다. 경구 투여 가능성과 생체내 종양 억제는 의미가 크지만, 아직 인간 임상 근거는 없다. 상업적 가치는 있으나 개발 리스크가 높다.
Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease.
The progression from metabolic dysfunction-associated steatotic liver disease (MASLD) to steatohepatitis (MASH) entails rapid, often irreversible hepatic injury, underscoring the urgent need for innovative therapeutic strategies. Here, we demonstrate that excessive dietary sugar intake, particularly…
인간 코호트 연관성과 전임상 기전이 함께 제시된 연구다. 임상적 근거는 아직 동물/전임상 수준이어서 제한적이지만, 미생물-대사축을 겨냥한 치료 전략으로서 의미가 있다. 상업적으로는 프로바이오틱스 기반 접근이라 가능성은 있으나 개발 리스크가 크다.
Target discrimination and PAM profiling of the Thermotoga maritima type I-B CRISPR system.
Type I-B CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) systems represent the most abundant CRISPR subtype in nature and have emerged as powerful tools for endogenous genome editing in diverse prokaryotes. Here we reconstitute and characterize the t…
이 연구는 열안정성 type I-B CRISPR 플랫폼을 재구성하고 PAM 특이성을 정밀하게 규명한 기초 연구다. 인간 임상과는 직접적 관련이 없지만, CRISPR 도구 개발과 합성생물학 측면에서는 의미가 있다. 상용화는 가능성이 있으나 아직 초기 단계다.
Six months predictors of DAPSA Remission With Guselkumab in Psoriatic Arthritis in a Multicenter Real-World Study.
Real-world evidence on 12-month outcomes of guselkumab (GUS) in psoriatic arthritis (PsA) remains limited. This multicenter observational study aimed to identify predictors of 12-month DAPSA remission (DAPSA < 4) in patients with PsA treated with GUS. Secondary objectives were to as…
Associations between early loss of skeletal muscle and osimertinib trough concentrations in patients with advanced EGFR-mutated NSCLC.
This study explores the associations between computed tomography (CT)-derived changes in body composition during the first three months of osimertinib monotherapy, systemic osimertinib exposure, and treatment outcomes in patients with advanced EGFR+ NSCLC….
Autophagy-Enhanced Nanoplatforms Eliminate Intracellular Bacteria and Block Bacteria-Driven Epithelial-Mesenchymal Transition for Tumor Metastasis Inhibition.
Tumor intracellular bacteria are a key driving force of epithelial-mesenchymal transition (EMT) in tumor cells, and EMT is a critical process in the metastasis cascade. Eliminating intracellular bacteria is a prospective therapeutic target for metastasis. However, existing targeted antibacterial app…
전임상 연구로서 임상적 근거는 아직 제한적이다. 그러나 종양 내 세균과 EMT를 연결한 기전은 흥미롭고, 새로운 항전이 치료 전략으로서의 가능성이 있다. 다만 실제 환자 적용까지는 추가 검증과 안전성 평가가 필요하다.
Lung-Targeted Delivery and Reactive Oxygen Species-Triggered Activation of Pro-protein for Antibacterial Therapy.
Protein therapeutics exhibit unparalleled target specificity but are often compromised by limited spatiotemporal control, leading to off-target effects and reduced in vivo efficacy. Herein, we report a modular chemical approach for the programmable regulation of protein activity via chemical conjuga…
마우스 폐렴 모델에서 표적 단백질 활성화와 항균 효과를 동시에 보여준 연구다. 임상 근거는 아직 전임상 수준이지만, 플랫폼 자체의 확장성과 전달 기술의 조합이 인상적이다.
Bispecific Macrophage Nano-Engager Couples Dual Checkpoint Blockade with Stimulator of Interferon Genes Activation to Potentiate Antitumor Immunity.
The immunosuppressive tumor microenvironment, characterized by impaired antigen presentation, “don’t eat me” signaling, and T-cell exhaustion, challenges effective cancer immunotherapy. Conventional T-cell-redirecting bispecific engagers (BiTEs) show limited efficacy in solid tumors because of poor …
전임상 마우스 모델에서 항종양 면역을 다축으로 강화한 나노면역치료 플랫폼이다. 임상 근거는 없지만 기전적 완성도와 확장성이 높아 후속 번역 연구 가치가 있다.
GFPT1 as a cross-ancestry validated target for degenerative spinal disease: genetic association in a Chinese cohort and functional characterization in zebrafish.
Degenerative spinal disease (DSD), including spinal stenosis and spondylosis, lacks effective pharmacological treatment. To identify druggable targets and assess cross-ancestry applicability, we integrate multi-omics analyses using Summary-data-based Mendelian Randomization (SMR), colocalization, an…
인간 유전학과 기능실험을 함께 제시해 타깃 신뢰도가 높은 편이다. 다만 아직 전임상 단계이며 임상적 효용은 입증되지 않았다. 상업적으로는 후보물질 제시 수준이라 추가 개발 리스크가 크다.
Injectable Binary-Amplified Cascade Hydrogels Suppress Post-Incomplete Microwave Ablation Relapse via Integrated Metallo-Metabolic-Immunomodulation.
Hepatocellular carcinoma (HCC) relapse following incomplete microwave ablation (iMWA) represents a formidable clinical challenge. This progression is fueled by residual tumor cells that exhibit cell death resistance and dysregulated fatty acid metabolism, while exploiting a myeloid-derived immunosup…
전임상 마우스 모델에서 간세포암 재발 억제 효과를 보인 연구다. 기전 통합성이 높고 면역치료 병용 가능성도 보여 발견적 가치는 크다. 다만 임상 근거는 아직 없고 상용화까지는 추가 검증이 많이 필요하다.
Self-Assembly, Phase Behavior, and Structure of Phenylalanine Alkyl Esters: Characterization of Lauryl Phenylalaninate-Lauryl Sulfate Catanionic Liposomes and Doxorubicin Encapsulation and Release.
Amino acid-based amphiphiles are gaining attention in pharmaceutical applications due to their biodegradability and low toxicity. In this study, we report the synthesis and characterization of a homologous series of l-phenylalanine alkyl esters (PAEs) with 8-20 C atoms in the alkyl chains. Their sel…
Censoring patterns and inconsistent results in checkpoint inhibitor and adjuvant BCG trials for high-risk bladder cancer.
Intravesical Bacillus Calmette-Guérin (BCG) is the standard-of-care treatment for high-risk non-muscle invasive bladder cancer (HR-NMIBC). However, patients with BCG-unresponsive disease are unlikely to benefit from further BCG. To overcome BCG unresponsiveness, the addition of immune checkpoin…
Impact of Single-Inhaler Triple Therapy FF/UMEC/VI on Disease Stability in COPD: A Real-World 12-Month Analysis.
Single-inhaler triple therapy with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) is recommended for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic or experience exacerbations despite dual bronchodilation. However, real-world evidence on its ability to ac…
15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss.
Glucagon-like peptide-1 receptor agonists, including long-acting semaglutide, are transformative anti-obesity therapies. However, emerging evidence indicates that weight loss may come at the expense of skeletal muscle mass, a tissue essential for mobility, metabolic regulation, and overall health. H…
Determinants of long-term survival from atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma.
Despite the proven superiority against sorafenib, atezolizumab plus bevacizumab (A+B) lacks long-term efficacy data in unresectable hepatocellular carcinoma (uHCC). This study assessed clinicopathologic factors associated with long-term survival with A+B….
Comparative Cardiovascular Effectiveness of Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Diabetes Mellitus.
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2Is) have established cardiovascular benefits for patients with type 2 diabetes mellitus (T2DM), with similar class-level effectiveness found in previous studies. However, real-world comparative e…
Efficacy of diflunisal for hereditary transthyretin amyloidosis: the Swedish real-world experience.
Diflunisal has been shown to slow the progression of hereditary transthyretin (ATTRv) amyloidosis. We examined the efficacy of diflunisal using data from SveATTR, a longitudinal Swedish registry open for patients with ATTR amyloidosis….
Real-world experience with gilteritinib maintenance following allogeneic transplantation in relapsed/refractory AML patients harboring FLT3 mutations.
Gilteritinib is an established FLT3 inhibitor used to treat patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) harboring FLT3 mutations. Prior studies have predominantly evaluated gilteritinib as a posttransplant maintenance therapy in patients who undergo allogeneic hematopoiet…
Systematic and quantitative analyses of hollow fiber model of Mycobacterium abscessus lung disease studies and new dosing recommendations.
Guideline-based combination therapy achieves sputum culture conversion rates in 23%-34% of patients with Mycobacterium abscessus-complex lung disease. Thus, new therapies are needed. We performed a systematic review to validate and benchmark the hollow fiber system model of M. abscessus lung disease…
Silk Fibroin Ionotronics for High-Performance Wearable Perovskite LEDs.
Hydrogels emerge as promising biointerfacing materials owing to their tunable mechanical properties and diverse biochemical functions. However, their application in electronics has been limited by the unsatisfactory conducting properties of hydrogels, typically functioning as insulators. Here, we tr…
A Miniaturized, Automated Proteomic Sample Preparation Platform for High-Throughput Target Deconvolution of Natural Products.
Natural products (NPs) are a major source of bioactive molecules for drug discovery, yet their development and translation are often limited by inefficient and ambiguous target identification. Although mass spectrometry-based proteomics has advanced rapidly, upstream sample preparation remains a cri…
The Phylum Fusobacteriota Is Associated with Colorectal Cancer-Specific Mortality: Results from the Translational Research Program in Cancer Differences across Populations.
The microbiome is an important component of the tumor microenvironment implicated in colorectal cancer. However, its relationship with colorectal cancer-specific mortality remains unclear….
Early and late survival dynamics of immunotherapy combinations in advanced HCC: Anchored indirect comparison of atezolizumab plus bevacizumab versus durvalumab + tremelimumab.
Atezolizumab plus bevacizumab (A+B) and STRIDE (tremelimumab plus durvalumab) represent two of the approved first-line immunotherapy strategies for unresectable hepatocellular carcinoma (HCC). As no head-to-head trial exists, we assessed temporal differences in survival benefit using complementary a…
Urinary Biomarkers of Exposure and Effect in California Schoolchildren From a High Air Pollution Area.
Exposure to air pollution is associated with adverse health effects such as asthma, lung cancer, and cardiovascular diseases. Children are especially vulnerable due to their developing organs, immature immune systems, and higher ventilation rates relative to their body size. Although the adverse hea…
Integration of Transcriptomics With Interpretable Artificial Intelligence for Identifying Molecular Signatures of Physiological Stress in Sleep Deprivation.
Sleep deprivation induces systemic physiological stress accompanied by transcriptomic remodelling and immune dysregulation, yet objective molecular indicators for its assessment remain insufficient. This study integrated blood transcriptomic analysis with an interpretable machine learning framework …
Evaluation of Clinically-Focused Artificial Intelligence Chatbots for Answering Drug Information Questions.
Artificial intelligence (AI) tools are increasingly promoted for clinical decision support in health care. While studies have assessed general-purpose AI chatbots on the accuracy and quality of clinical or drug-related questions, direct comparison among multiple clinically-focused AI chatbots is lac…
Prior Chlamydia trachomatis Infection and the Risk of Epithelial Ovarian Cancer and Borderline Ovarian Tumors.
The aim of this study was to investigate the association between serum IgG antibodies to C. trachomatis major outer membrane protein (MOMP), iron-binding periplasmic protein TroA, and high temperature requirement protein (HtrA), and the occurrence of epithelial ovarian cancer (EOC) and borderline ov…
Methionine, Homocysteine, and Methylation Levels Predict Cognitive Decline in Alzheimer’s Disease.
Alzheimer’s disease (AD), the most common cause of dementia, involves metabolic factors such as homocysteine, methionine, and DNA methylation in its pathogenesis. However, the precise interactions among these factors and their impact on cognitive function in AD require further elucidation….
Protective Effect of Vitamin E Against Vancomycin-Induced Nephrotoxicity: A Large-Scale Electronic Medical Record Study From Japan.
Vancomycin (VCM) is essential for treating methicillin-resistant Staphylococcus aureus infections, but its use is limited by vancomycin-induced nephrotoxicity (VIN). Although preclinical and small clinical studies suggest a protective role for vitamin E, real-world evidence remains limited. We condu…
Establishment and Molecular Characterization of a Short-Term Primary Culture Derived From Invasive Micropapillary Carcinoma of the Breast.
Invasive micropapillary carcinoma (IMPC) of the breast, a rare and aggressive subtype, represents a unique morphology of reversed polarity with higher metastatic propensity. Due to the limited availability of experimental models, understanding distinct molecular pathways and potential therapeutic ta…
Multi-Omics Profiling Reveals PDK4 as a Key Regulator of Acute Lung Injury in Glufosinate-Ammonium Poisoning.
Glufosinate-ammonium (GA) is a widely utilised herbicide. With the gradual phase-out of highly toxic herbicides, the usage rate of GA as an alternative herbicide has significantly increased, which has led to a rise in GA poisoning incidents. In this study, an acute GA poisoning mouse model was const…
Associations between oral migraine preventive regimens and CGRP monoclonal antibody initiation: real-world evidence from a resource-limited setting.
Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) are effective migraine-specific preventive therapies; however, access remains limited in many low- and middle-income countries (LMICs). In such settings, oral migraine preventive medications (OMPMs) continue to serve as the foundation…
Predictive Role of Triglyceride-to-High-Density Lipoprotein-Cholesterol Ratio and Triglyceride-Glucose Index in Glycaemic Control among Type 2 Diabetes Mellitus Patients with Chronic Kidney Disease.
This study explores the potential of the triglyceride-to-high-density lipoprotein-cholesterol (TG/HDL-C) ratio and the triglyceride-glucose (TyG) index as alternative markers of glycaemic control in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Conducted on 91 adult…
Epigenetic reprogramming of tissue-resident memory T cells in chronic inflammatory disorders and implications for targeted therapies.
Tissue-resident memory T (TRM) cells play a role in causing long-term tissue injury in chronic inflammatory diseases via pathological epigenetic reprogramming. Nevertheless, the epigenetic processes that cause this malfunction have not been well defined….
Coexpression of IL15 Promotes Effector Differentiation and Sustained Proliferative Capacity in ALPPL2-Specific Human CAR T Cells.
Chimeric antigen receptor (CAR) T cells have robust antitumor activity against hematologic malignancies and have the potential to benefit patients with solid tumors. Immune recognition of murine proteins expressed in adoptively transferred T cells and the lack of homeostatic cytokines in the tumor m…
Incidence and outcome of oropharynx carcinoma in Denmark 1986-2020: A population based DAHANCA study.
The global incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) varies widely. Long-term, population-based studies with consistent treatment protocols are essential for understanding geographic differences in viral impact, treatment response and survival. With this nationwide popul…
Prognostic impact of weight loss during first-line chemotherapy in extensive-disease small cell lung cancer.
The adverse prognostic impact of cancer cachexia is well recognized. We aimed to evaluate the prognostic impact of weight loss during first-line platinum-based chemo(immuno)therapy in patients with extensive-disease small-cell lung cancer (ED-SCLC)….
Fibroblast activation protein and down-stream effects on its substrates in metabolic dysfunction-associated steatotic liver disease.
Fibroblast activation protein (FAP) is a serine protease upregulated in liver and blood in patients with chronic liver disease of several etiologies. FAP has a pro-fibrotic effect and may also regulate disease progression by proteolytically affecting two circulating substrates, fibroblast growth fac…
Real-world-data for phenotypes and genotypes of rare monogenic genetic epilepsies and genes of uncertain significance for epilepsy.
The objectives of this study were to develop a real-world-data (RWD) database for patients with epilepsy to provide further real-world-evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico…
Prostate cancer mortality among men with and without comorbidity: Long-term results from the European randomized study of screening for prostate cancer Rotterdam.
Prostate-specific antigen (PSA)-based prostate cancer (PCa) screening can be improved by individualised, risk-stratified strategies. Comorbidity influences life expectancy, so may affect benefits of screening. We evaluated whether the effect of PSA-screening on PCa-specific mortality (PCSM) differed…
CPSM: An R Package for Cancer Patient Survival Risk Model Using Transcriptomics and Clinical Data.
Traditional Kaplan-Meier curves capture aggregate survival trends within broad patient subgroups but overlook the heterogeneity of individual patients. In contrast, single-patient survival risk models bridge this gap by incorporating each patient’s unique clinical, genomic, and demographic character…
Income, treatment patterns and outcome in patients with stage IV colorectal cancer.