Pubmed Today 2026Jun13

CAR-T therapy is highly effective in hematologic malignancies but remains challenging in solid tumors. To address this challenge, here, we developed SHIFTERS (solid-tumor hallmark inducible, focused-ultrasound triggered enhanced reprogramming system), an AND-gated circuit that rewires tumor hallmark…

고형암 CAR-T의 핵심 한계를 해결하려는 플랫폼으로 의미가 크다. 다만 아직 전임상 단계이므로 임상적 파급력은 제한적이다. 기술적 독창성은 매우 높아 후속 검증 가치가 있다.

Extending the dosing interval with the anti-vascular endothelial growth factor (VEGF) brolucizumab in the loading phase may reduce treatment burden while maintaining functional and anatomical outcomes for patients with neovascular age-related macular degeneration….

Moyamoya disease (MMD) is a progressive cerebrovascular disorder characterized by abnormal vascular remodeling and impaired angiogenesis. We profiled plasma extracellular vesicle (EV)-derived microRNAs (miRNAs) from MMD patients and healthy controls and generated patient-specific induced pluripotent…

환자 유래 iPSC-EC와 혈장 EV를 함께 사용해 인간 기반 근거를 제시한 점이 강점이다. 다만 아직 기능 회복은 세포 수준이며 임상 적용까지는 추가 검증이 필요하다. AI 프레임워크는 흥미롭지만, 현재로서는 가설 생성 도구에 가깝다.

Pelvic exenteration (PE) has evolved from a palliative “procedure of desperation” into a potentially curative operation for selected patients with locally advanced or recurrent pelvic malignancy. Christchurch Hospital has delivered PE for more than three decades and has been an active contributor to…

Withania somnifera (L.) Dunal (Ashwagandha) has long been utilized in traditional medicine for its rejuvenating and anticancer properties. Withanolides, its major bioactive constituents, are known to influence multiple oncogenic pathways. Elucidating the molecular mechanisms underlying these effects…

Kochiae Fructus is a traditional herbal medicine used to treat a variety of skin conditions. Momordin Ic, the main bioactive pentacyclic triterpenoid saponin component of Kochiae Fructus, is known for its broad pharmacological effects, including antioxidative and anti-inflammatory. However, its ther…

Patients on low-dose prednisolone may develop adrenal insufficiency causing reduced health-related quality of life (HRQoL) and increased risk of adrenal crisis. This study examines whether supplemental hydrocortisone during mild to moderate stress improves HRQoL in patients with polymyalgia rheumati…

Postmastectomy pain syndrome (PMPS) is a prevalent chronic pain condition that occurs after breast cancer surgery, often impairing quality of life in survivors of breast cancer. Despite its prevalence, no standardized treatment has been established. Acupuncture has been reported to be an efficacious…

Ferroptosis is an iron-dependent form of regulated cell death. However, the critical regulators that restrain iron overload to suppress ferroptosis remain undefined. Utilizing multi-omics, we identify the E3 ubiquitin ligase membrane-associated RING-CH 7 (MARCH7) as a non-redundant, dual suppressor …

새로운 ferroptosis 조절 축을 제시한 점이 크다. 다만 임상 근거는 전임상 수준에 머물러 있어 직접적인 환자 적용 가능성은 아직 제한적이다. 기전적 새로움과 약물화 가능성은 높아 후속 연구 가치가 있다.

Residual coronary microvascular dysfunction (CMD) is common after STEMI despite successful primary PCI and may contribute to ongoing ischemia and impaired recovery. INaMICRON will test the hypothesis that early late INa current inhibition with ranolazine, added to guideline-directed medical therapy,…

Stenotrophomonas maltophilia is an opportunistic multidrug-resistant pathogen increasingly associated with severe infections. Although cefiderocol has demonstrated potent in-vitro activity against S. maltophilia, clinical evidence remains limited. We performed a retrospective multicenter study inclu…

Chimeric antigen receptor T cells (CAR-T cells) have been widely applied in hematologic malignancies. It has shown limited efficacy in the treatment of myeloid neoplasms. We retrospectively analyzed the safety and efficacy of CD123 CAR-T cells in 15 patients with myeloid neoplasms (ChiCTR2000041054)…

Pituitary adenomas (PA) are benign neoplasms treated by resection. Gross total resection is limited by extrasellar expansion in proximity to critical neurovascular structures. Residual tumor remains at risk of progression, with serious consequences such as optic compression or hormone hypersecretion…

Recent advances in digital therapeutics (DTx) have led to the development of game-based, home-delivered interventions for children with attention-deficit/hyperactivity disorder (ADHD). Prior studies have demonstrated the feasibility and clinical potential of DTx for reducing ADHD symptoms but have p…

Cellular senescence is implicated in age-related pathologies, and identifying circulating biomarkers of senescence holds great diagnostic potential. Circulating senescence signatures are predictive of age-related traits and diseases, though cell type senescence signatures have not been comprehensive…

Cellular senescence comprises diverse cell states emerging across human tissues during aging and disease. Integrating single-cell and spatial multi-omics with AI-driven analyses enables systematic mapping of senescent cell heterogeneity (“senotypes”), revealing tissue-specific programs and microenvi…

인간 조직에서 노화 세포의 이질성을 체계적으로 지도화한 개념적·분석적 연구다. 임상 근거는 아직 직접적이지 않지만, 바이오마커와 표적 발굴 측면의 파급력은 있다.

To characterize circulating immunabolic profiles associated with sarcopenia and muscle strength in middle-aged and older adults living at high altitude using an integrated multi-omics approach….

Prostate cancer (PCa), the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. A particularly aggressive group of PCa, where prognostic biomarkers are still needed, are clinically defined high-risk PCa. We had previously shown that the survival and proli…

Renal fibrosis (RF), a common pathological process driving chronic kidney disease (CKD) progression to end-stage renal failure, is closely associated with oxidative phosphorylation (OXPHOS). Arctigenin (ATG), the main active component of burdock seed, exhibits anti-inflammatory and anti-fibrotic act…

전임상 동물모델에서 아르크티제닌의 항섬유화 기전을 다중오믹스로 제시한 연구다. 임상 근거는 없으므로 임상 영향은 낮지만, 미토콘드리아 OXPHOS를 표적하는 새로운 기전 제시는 의미가 있다. 상업성은 자연물 기반 전임상 단계로 아직 제한적이다.

Intervertebral disc degeneration (IVDD) is a leading cause of chronic disabling musculoskeletal disorders, with its incidence rising annually among the aging global population. This degenerative process is strongly linked to persistent functional impairment and reduced quality of life in patients, w…

Diabetes distress (DD) is common and evolves heterogeneously over time. We aimed to estimate minimal clinically important differences (MCID) for the Problem Areas in Diabetes (PAID) scale and its sub-dimensions and to identify predictors of worsening over 1 year in people with type 1 diabetes (PwT1D…

Rapid diagnostics such as the BIOFIRE® FILMARRAY® Pneumonia (PN) Panel may enhance antibiotic optimization, yet real-world evidence remains limited, and few studies have assessed how differences in institutional antimicrobial stewardship (ASP) capacity influence clinical outcomes….

Epitranscriptomic regulation of tRNA modifications has emerged as an important mechanism in cancer progression by influencing oncogenic translation. Anaplastic thyroid carcinoma (ATC) is a highly aggressive malignancy with limited therapeutic options. Although N-acetyltransferase 10 (NAT10) is frequ…

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary heterocyclic amine generated during high-temperature cooking, has been implicated in colorectal cancer (CRC); however, its underlying molecular mechanisms remain incompletely understood. In this study, we provide experimental evidence…

Aortic stenosis (AS) and left ventricular diastolic dysfunction (LVDD) often coexist in heart failure (HF), but the mechanisms linking them remain unclear. While AS increases afterload and promotes myocardial stiffening, emerging AI-based evidence suggests LVDD can precede the development of AS or p…

Abdominal massage (AM), a traditional Chinese medicine treatment, is gradually being recognized in clinical practice for its ability to improve the symptoms of obesity and type 2 diabetes mellitus (T2DM) in clinical practice. This study aimed to investigate the effect of AM on an obesity-associated …

Unresectable hepatocellular carcinoma (HCC) remains a major global health burden. Immunotherapy-based combinations have become the standard of care in first-line (1L) treatment, but evidence on subsequent therapies is limited. This study aimed to describe access to and outcomes of second-line (2L) t…

Emerging digital and bioelectronic technologies are rapidly transforming interventional pain management, but their clinical roles and evidence base remain unclear. A scoping review of these innovations is needed to map the current landscape and identify gaps for future research….

Bronchiectasis is a heterogeneous chronic airway disease primarily driven by persistent infection, microbial dysbiosis and dysregulated host immunity. While culture-based microbiology has historically informed clinical management, advances in high-throughput sequencing and multi-omic technologies ha…

The rising incidence of Mycobacterium avium (MAV) infection poses significant challenges due to diagnostic delays and refractory treatment. Understanding host immune remodeling-particularly myeloid heterogeneity-is critical for identifying precise therapeutic targets….

Urolithiasis, a recurrent and increasingly prevalent disease worldwide, has a complex pathophysiology that hinders a comprehensive understanding….

Pathogenic New World arenaviruses (NWAs), including Junín (JUNV) and Machupo (MACV) viruses, rely on host-virus entry processes that represent attractive points for antiviral intervention. Guided by the known use of human transferrin receptor 1 (hTfR1) by several NWAs for cell entry, we conduct…

전임상 단계의 항바이러스 후보 발굴 연구다. 구조기반 스크리닝과 히트 최적화로 의미 있는 활성을 얻었지만, 동물 효능이 없어 임상적 파급력은 제한적이다.

Acute Pancreatitis (AP) is a pancreatic inflammatory disease lacking specific therapeutics. Da-Cheng-Qi Decoction (DCQD) has been proven to alleviate the severity and mortality of AP. However, its underlying mechanisms remain to be fully elucidated….

Polygoni cuspidati rhizoma et radix, derived from Reynoutria japonica Houtt., a medicinal and invasive plant, has traditionally been used in East Asia for inflammatory and suppurative conditions, including ailments affecting the oral cavity, and is listed in both the Chinese and European Pharmacopoe…

Polymerization is a major pathological feature of sickle cell disease (SCD). Although conventional therapies reduce disease severity, their use is limited by adverse effects, high cost, and poor accessibility in resource-limited settings. Vigna sesquipedalis (L.) F.Agcaoili, a leguminous plant widel…

Yishen Qutong Formula (YSQTF) is composed of six ingredients of Liuwei Dihuang, a classical traditional Chinese medicine fomula, plus Drynaria fortunei (Kunze) J. Sm., Bombyx Batryticatus, Hedyotis diffusa Willd, Scutellaria barbata D. Don. YSQTF has been proved effective in clinical practice of can…

Kaiyujiangzhuo formula (KYJZ) is an optimized herbal formulation derived from the classical prescription “Dahuang Huanglian Xiexin decoction,” recorded in the ancient Chinese monograph Shang Han Lun. For many years, KYJZ has been used to treat glycolipid metabolic disorders in China, particularly in…

Metabolic-associated fatty liver disease (MAFLD) is emerging as a very serious threat to human health. The search for effective remedies for MAFLD from natural herbs is gaining increasing attention. Swertia chirayita (SC) is a famous herb in China, India, and Nepal. It has long been employed within …

Aristolochiae Fructus (AF) is a “notable” Traditional Chinese Medicines (TCM), renowned for its efficacy in clearing lung heat, descending qi, relieving cough and asthma, as well as its well-documented toxicity. Traditionally used for conditions such as lung heat with cough and dyspnea, and hemorrho…

Lycopi Herba is a traditional Chinese medicine with blood-activating and stasis-resolving properties, traditionally prescribed to promote diuresis and alleviate edema. These traditional indications are closely related to the pathogenesis of diabetic nephropathy (DN), characterized by renal fibrosis …

Chaihu Shugan San (CSS), a classical Traditional Chinese Medicine (TCM) formula, was first recorded in Jingyue Quanshu (1624 AD) for treating “liver qi stagnation” (Yu Syndrome), a TCM diagnostic pattern analogous to modern mood disorders. Although CSS has been prescribed for emotional distress, irr…

Metabolic dysfunction-associated steatohepatitis (MASH), a chronic liver disease characterised by ballooning degeneration of hepatocytes, inflammation and fibrosis, has become a global health concern. Yanxiao Di’naer decoction (YD) is a Uyghur medical compound used for the treatment of hepatitis. Ne…

Buyanghuanwu decoction (BYHWD), a classical Traditional Chinese Medicine (TCM) formula, has been widely used for treating cardiovascular and cerebrovascular diseases in China. Accumulating evidence confirms its efficacy in ameliorating organ fibrosis (e.g., pulmonary, renal and myocardial fibrosis),…

Chinese expert consensus shows that Sijunzi decoction (SJZD) can improve cancer cachexia myatrophy (CCMA) in clinical, but its mechanism remains unclear….

Renal fibrosis (RF) is a pivotal pathological process in chronic kidney disease (CKD), driven by tubular epithelial-mesenchymal transition (EMT). Although Qingshen Granules (QSG) demonstrate clinical efficacy against CKD, their anti-fibrotic mechanisms, particularly concerning mitophagy regulation, …

Bawei Chenxiang Wan (BWCX) is a classical Tibetan medicinal formula originating from the canonical Tibetan medical text The Four Tantras. It is traditionally used to activate qi circulation, nourish the heart, tranquilize the mind and enhance intelligence. It has been applied for over a thousand yea…

Gastrodiae Rhizoma (GR), the dried tuber of the orchidaceous plant Gastrodia elata Bl., has been utilized in traditional medicine for over two millennia. As a valuable traditional Chinese herb in both medical and dietary applications, GR is known for its neuroprotective effects and use in improving …

Babaodan (BBD), a traditional Chinese medicine formula with a history of clinical use, has been extensively applied in the treatment of various hepatic disorders, but its multi-target mechanisms of metabolic dysfunction-associated fatty liver disease (MAFLD) remain unclear and limit its scientific d…

Smilax glabra Roxb. (taxonomically verified via http://www.theplantlist.org, accessed December 17, 2025), commonly known as “Tu fuling” in China, is a well-recognized traditional Chinese herb extensively used for detoxification, dampness relief, and diuresis. Our previous research has demonstrated t…

Hyperlipidemia is a major risk factor for cardiovascular diseases. Clematis tangutica (Maxim.) Korsh. (CT), a commonly used Tibetan medicine for cardiovascular disorders, has rarely been reported for its lipid-lowering efficacy and mechanism….

The Shenqiyichang (SQYC) decoction is a traditional Chinese formula for the treatment of colorectal cancer (CRC) in clinic. It has been demonstrated to effectively suppress the progression of tumors and enhance patients’ quality of life. Nonetheless, its anti-cancer molecular mechanisms are not clea…

Gastric precancerous lesions (GPL), the inflammation-driven precursors of gastric cancer (GC), may be propelled by neutrophil extracellular traps (NETs). Jianpi Fuzheng Xiaoji formula (JPFZXJ) is a standardized herbal formulation that translates the ancient “reinforce healthy qi to eliminate pathoge…

Infection of vaginal epithelial cells by Candida albicans (C. albicans) can cause vulvovaginal candidiasis (VVC). Pulsatilla decoction has been reported and used to treat VVC, but the specific mechanism of its protective effect on cells is still unclear….

Different gentian preparations are used as traditional remedies for internal pain control. However, comparative data on different Gentiana species are scarce, and their therapeutic potential remains underexplored….

Chemotherapy-induced neuropathic pain (CINP) is a frequent side effect of chemotherapy, and the mechanisms by which Huangqi Guizhi Wuwu Tang (HQGZWWT) prevents and treats CINP remain to be further elucidated….

Pancreatic β-cell differentiation and regenerative capacity differ markedly between developmental stages, with the neonatal pancreas exhibiting high plasticity that enables ongoing progenitor- and ductal-derived β-cell formation, whereas the adult pancreas demonstrates limited neogenic p…

Promoting the effectiveness of antibiotics against multidrug-resistant bacteria is necessary to overcome the global antimicrobial resistance crisis. Methicillin-resistant Staphylococcus aureus (MRSA) is notorious for its β-lactam resistance and high antibiotic tolerance, due to its ability to …