📅 2026년 6월 11일 | PubMed 수집 논문
★ 주요 논문 — 이번 수집의 하이라이트
Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin.
Glial crosstalk surrounding amyloid-β (Aβ) plaques establishes a self-propagating inflammatory niche fueling Alzheimer’s disease (AD), yet the molecular triggers remain incompletely defined. We found that the calcium-dependent enzyme peptidyl-arginine deiminase 2 (PAD2) was selectively u…
A sodium phytate-ethyl cellulose coating with sustained oleoyl serine release enables spatiotemporal osteoimmune regulation of magnesium implants.
Biodegradable magnesium (Mg) implants hold immense potential in orthopedics, yet their rapid degradation, insufficient osseointegration, and immune imbalance remain major barriers to clinical translation. This study developed a sodium phytate (SP) passivation layer and an ethyl cellulose (EC) barrie…
Integrated multi-omics profiling of treatment-naive cervix uteri premalignant lesions and cervical squamous cell carcinoma reveals ecosystem and drivers underlying cervical cancer progression.
The tumorigenesis and progression of conventional cervical squamous cell carcinoma generally follow a well-defined cascade: from normal cervix uteri to high-grade cervical intraepithelial neoplasia (precancer), cervical carcinoma in situ, and ultimately invasive cervical carcinoma. However, biomarke…
Chirality in hydrogels assembled from D- or L-amino acid derivatives regulates immunological responses during diabetic wound healing.
Immunomodulatory biomaterials that perform specific host immune responses have shown great prospects for immunotherapies and regenerative medicine. Although there is a growing recognition of chirality in manipulating cell behavior, the regulatory role of matrix chirality on immune cell function and …
Caspase-1-targeting siRNA nanoparticles suppress pyroptosis to prevent force-induced root resorption.
Mechanical force-induced hard tissue defects are clinically prevalent, particularly in dentistry. Excessive mechanical stimulation could induce pathological tooth root resorption (RR), which leads to tooth mobility and even tooth loss. This process is closely associated with dysregulated biological …
Nano-immunomodulators co-activate immunogenic cell death and the cGAS-STING pathway for breast cancer immunotherapy.
Breast cancer generally does not respond to immunotherapy due to its inherently low immunogenicity and insufficient coordination between innate and adaptive immune responses. Here, we demonstrated that concurrent activation of immunogenic cell death (ICD) and the cyclic GMP-AMP synthase-stimulator o…
Charge-driven lipid nanoparticle encapsulation of enzymes for enhanced ERT with reduced immunogenicity.
Efficient intracellular delivery of therapeutic enzymes remains a central limitation of protein-based therapies. In lysosomal storage disorders such as Pompe disease, classical enzyme replacement therapy (ERT) is particularly constrained by inefficient delivery to skeletal muscle, limited cellular u…
A versatile capsule-intravaginal ring platform enables rapid and sustained release of monoclonal antibodies for non-hormonal contraception.
Non-hormonal contraceptives that do not require use immediately before or after intercourse would likely meet the reproductive health needs of millions of women. We previously reported the engineering of MM008, a highly multivalent monoclonal antibody with 10 Fabs against a unique human sperm antige…
DNA-directed assembly of multivalent lipid nanoparticles for targeted T cell gene delivery.
Lipid nanoparticles (LNPs) are a powerful emerging tool for in vivo T cell engineering to treat diseases ranging from B cell lymphomas and other cancers to autoimmune diseases. Key challenges in designing these therapeutics include achieving both precise cell targeting and efficient mRNA translation…
Biomaterials-guided nanomedicine for familial adenomatous polyposis: lipid nanopartiscle RNA therapeutics with translational relevance.
Familial adenomatous polyposis (FAP) is a genetic disorder primarily driven by mutations in the adenomatous polyposis coli (APC) gene, leading to hereditary colorectal cancer. Without intervention, FAP almost invariably progresses to colorectal carcinoma. Due to the large molecular weight of APC pro…
Chelator-guided radiosynthesis, preclinical evaluation, and clinical study of [68Ga]Ga-TRAP-(FAPI)3 for positron emission tomography imaging of tumors.
Tumor visualization based on nuclear medicine molecular imaging techniques offer a robust approach for early malignancy detection, staging, and prognosis assessment. Screening pathological targets is fundamental to advance the development of targeted radiopharmaceuticals. Recently, radiolabeled inhi…
Cyclic monochalcogen bonds enable improved stability and fine-tuned activation of dimeric prodrug nanoassemblies for potent cancer therapy.
Homodimeric prodrug nanoassemblies (HPNs) have attracted attention as an effective approach to enhance the delivery efficiency of chemotherapeutic drugs. The chemical linkages are critical determinants of the therapeutic performance and safety profile of the HPNs. Previous studies have shown that th…
Endogenous targeting lipid nanoparticles for systemic mRNA delivery to lung cancer tumors.
Systemic delivery of mRNA therapeutics to lung cancer tumors remains challenging despite recent advances in organ-targeting lipid nanoparticles (LNPs). This study introduces novel LNPs, comprising commercially available DC-cholesterol (a cationic derivative of cholesterol) and 113-O12B ionizable lip…
Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment.
The repair and reconstruction of critical-sized bone defects pose substantial clinical challenges, particularly owing to the limited self-healing capacity of the central regions. Inspired by the structure and function of a “flowerbed,” we developed a biomimetic composite scaffold by embedding a magn…
Manganese-tannic acid immunomodulators potentiate PDGFRβ CAR-T cell function for additive therapy against liver fibrosis.
Chimeric antigen receptor (CAR)-T cell therapy has achieved considerable success in treating malignant tumors. However, its therapeutic efficacy in hepatic fibrosis remains unclear. The activated hepatic stellate cells (aHSCs) represent a central driver in the initiation and progression of liver fib…
β-glucuronidase-triggered ortho-hydroxyl-mediated cyclization strategy for the efficient delivery of phenolic payloads in antibody-drug conjugates.
While the payload landscape of antibody-drug conjugates (ADCs) has diversified beyond amine-containing compounds, the application of potent cytotoxic agents possessing phenolic hydroxyl groups remains restricted. This is primarily due to the scarcity of linker technologies capable of balancing syste…
Biomimetic trident lipid anchoring enables stable neutrophil-based combination therapy.
Anchoring-conjugation strategy, characterized by benign hydrophobic membrane anchoring and swift covalent drug-coupling, has been extensively practiced to attach therapeutic agents to cell surfaces in cell-based combination therapies. However, this approach faces significant challenges in phagocytic…
Fine-tuned phenylboronic acid polymer assembly with tannic acid enables adeno-associated virus to evade and suppress neutralizing antibody responses.
Adeno-associated virus (AAV) has emerged as a promising vector for gene therapy; however, its therapeutic efficacy is often limited by pre-existing and treatment-induced neutralizing antibodies (NAbs). To address this challenge, we developed an AAV-loaded ternary complex through the sequential assem…
Targeting DNA repair with a Pt(IV) prodrug nanoparticle potentiates chemo-immunotherapy for nasopharyngeal carcinoma through cGAS-STING activation.
Cisplatin-based chemotherapy combined with immunotherapy is the standard first-line treatment for advanced nasopharyngeal carcinoma (NPC), but its efficacy is limited by off-target toxicity, platinum resistance, and the immunosuppressive tumor microenvironment (TME). Herein, we report NP2, a reactiv…
A copper-based ascorbic acid-activatable gel for postoperative glioblastoma therapy.
Glioblastoma (GBM) is prone to rapid postoperative recurrence, primarily due to its invasive growth pattern and immunosuppressive microenvironment. To combat these challenges, we developed an ascorbic acid (AA)-responsive implantable gel crosslinked by copper ions, denoted as CuTR-gel, for postopera…
Biomineralized nanoemulsion delivers mRNA for potent cancer immunotherapy.
mRNA vaccines show great promise in cancer immunotherapy by eliciting potent cellular immune responses. Lipid nanoparticles (LNPs), validated through widespread use in COVID-19 vaccination, have become the most widely studied platform. However, their reliance on PEGylated lipids and tendency for hep…
Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.
Acute myeloid leukemia (AML) remains a fatal malignancy with poor prognosis due to limited drug bioavailability and therapeutic resistance within the protective bone marrow niche. Here, we present a bone marrow-targeted lipid nanoparticle employing a “Bait and Extravasation” approach for the co-deli…
Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking.
We developed an injectable and transient hydrogel with a programmable lifetime by introducing closed functional loops, specifically gelation and sol transition pathways, within the system. Gelation occurs through the formation of coordination crosslinking between a phosphate ester and its affinity l…
Cu2+-chelated epigallocatechin gallate nanoparticle-functionalized hydrogel promotes osteogenesis by inhibiting ferroptosis.
A pathological inflammatory microenvironment can hinder bone regeneration by disrupting the osteogenic differentiation potential of bone marrow-derived mesenchymal stem cells (BMSCs). However, conventional anti-inflammatory therapies alone are insufficient to fully resolve this challenge. Bone defec…
Nano-sized DNase scavenges cell-free DNA for acute lung injury treatment.
Excessive release of cell-free DNA (cf-DNA) from damaged cells activates DNA sensors, triggering robust inflammatory responses and contributing to the pathogenesis of acute lung injury (ALI). To address this, we developed a nano-sized DNase system by conjugating DNase I onto PEGylated bilirubin (BR)…
Targeted and quantitatively modeled biologic delivery via dual-functional probiotic yeast in inflammatory bowel disease.
Probiotic-based therapies are an emerging class of therapeutic interventions that offer a promising strategy for managing chronic and inflammatory conditions. Here, we engineered a dual-functional probiotic yeast strain, Saccharomyces boulardii, designed to target inflammatory lesions within the gas…
MAZ-driven MRPL11 links mitochondrial homeostasis to AKT/mTOR signaling and promotes pancreatic ductal adenocarcinoma progression.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, owing to late diagnosis, rapid progression, and resistance to therapy. Here, we identify mitochondrial ribosomal protein L11 (MRPL11) as a novel oncogenic driver of PDAC. Multi-omics and survival analyses revealed t…
Obesity history exacerbates liver macrophage-mediated fibrosis via IGFBP7.
Weight regain is a frequent outcome after lifestyle-induced weight loss and is closely linked to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanisms by which prior obesity predisposes to metabolic dysfunction-associated steatohepatitis (MASH) …
In vivo generation of fibrolytic macrophages via LNP-CSF1 mRNA attenuates liver fibrosis.
Liver fibrosis, a common consequence of chronic liver injury, imposes a substantial global health burden. While autologous infusion of ex vivo-induced macrophages has shown therapeutic potential, such cell-based strategies remain limited by high costs and operational complexity, underscoring the nec…
Targeted microwave sensitizers reprogram cancer-associated fibroblasts via nitric oxide delivery to potentiate hepatocellular carcinoma therapy.
Microwave ablation (MWA) has emerged as a locoregional therapeutic modality for the management of various solid tumors. However, MWA often struggles to completely eliminate tumor cells without damaging surrounding healthy tissue. This triggers the persistence of an immunosuppressive microenvironment…
Bio-inspired fractal-structured gel-drugs enable enhancing deep tumor penetration for efficient chemotherapy of hepatocellular carcinoma.
Current nanoparticle-based drug delivery systems present significant challenges in treating solid tumors, primarily due to a variety of physiological and pathological barriers that hinder the deep penetration of drugs. Herein, we demonstrate bio-inspired fractal-structured gel-drugs (DOX@HPLA, DHPL)…
Delivery routes and circular mRNA vaccine architecture synergistically shape in vivo immune profiles.
The administration route and molecular architecture of nucleic acid vaccines are known to independently influence immunogenicity, yet how they interact to cooperatively shape in vivo immune polarization remains unexplored. This knowledge gap critically hinders the rational design of circular RNA (ci…
Extracellular vesicle-mediated HIF-1α delivery promotes durable vascular remodeling via endothelial Dll1-dependent CD163+ macrophage differentiation.
Critical limb ischemia (CLI) is a severe vascular disease with limited pharmacologic treatments and a high risk of amputation. Conventional therapeutic angiogenesis, mainly based on single growth factors, has failed to achieve stable and functional vessel formation. Recent insights indicate that int…
Engineered microglial membrane-coated polydopamine-based nanomedicine for precise treatment of Alzheimer’s disease.
Multimodal treatment for Alzheimer’s disease (AD) is a pivotal option because of its complex pathogenesis. The major challenge of pharmacotherapies is effective drug delivery to the diseased brain and reduction of associated toxicity. Here, we propose a dual-target nanomedicine (PDA@R@M/K) for the m…
Implantable piezocatalytic enzyme hydrogel re-engineers metabolic reprogramming for ischemic stroke therapy.
Internal wireless electric stimulation (ES) based on piezoelectric materials with ultrasound (US) stimulation has emerged as a promising noninvasive strategy of tissue regeneration. However, due to poor electric field generation and their inherent ability to generate reactive oxygen species (ROS), p…
Composite nanovesicles for enhanced chemodynamic cancer therapy via decitabine-mediated epigenetic reactivation.
Chemodynamic therapy (CDT) has been widely explored for the treatment of various solid tumors. However, its efficacy is severely limited by insufficient reactive oxygen species (ROS) amplification and epigenetic silencing of key immune-regulatory genes. Herein, we developed a composite nanovesicle (…
Ibogalogs and their pyridoindole homologs activate or inhibit the 5-HT2B receptor by modulating the distance between transmembrane segments TM3 and TM6 in the orthosteric site.
Previous behavioral studies showed that ibogalogs induce beneficial effects in various neurological animal paradigms (see Introduction). Thus, the binding, functional, and mechanistic characterization of ibogalogs and their pyridoindole homologs at the serotonin subtype 2B receptor (5-HT2BR) is esse…
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Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin.
Glial crosstalk surrounding amyloid-β (Aβ) plaques establishes a self-propagating inflammatory niche fueling Alzheimer’s disease (AD), yet the molecular triggers remain incompletely defined. We found that the calcium-dependent enzyme peptidyl-arginine deiminase 2 (PAD2) was selectively u…
인간 AD 조직과 마우스 모델을 함께 사용해 기전과 효능을 모두 제시한 연구다. 임상 근거는 전임상 수준이지만, 표적의 명확성과 약물 개입 결과가 좋아 추적 가치가 높다.
A sodium phytate-ethyl cellulose coating with sustained oleoyl serine release enables spatiotemporal osteoimmune regulation of magnesium implants.
Biodegradable magnesium (Mg) implants hold immense potential in orthopedics, yet their rapid degradation, insufficient osseointegration, and immune imbalance remain major barriers to clinical translation. This study developed a sodium phytate (SP) passivation layer and an ethyl cellulose (EC) barrie…
마그네슘 임플란트의 급속 분해와 골유합 부족 문제를 동시에 다루는 점이 의미 있다. 다만 현재는 쥐 모델 수준이므로 임상적 근거는 제한적이다. 플랫폼 자체의 조합은 흥미롭지만 상용화까지는 추가 검증이 필요하다.
Integrated multi-omics profiling of treatment-naive cervix uteri premalignant lesions and cervical squamous cell carcinoma reveals ecosystem and drivers underlying cervical cancer progression.
The tumorigenesis and progression of conventional cervical squamous cell carcinoma generally follow a well-defined cascade: from normal cervix uteri to high-grade cervical intraepithelial neoplasia (precancer), cervical carcinoma in situ, and ultimately invasive cervical carcinoma. However, biomarke…
인간 조직을 직접 분석한 다중오믹스 연구로, 전암성 병변의 진행 기전을 비교적 설득력 있게 제시한다. 다만 임상 근거는 아직 탐색적 수준이며, 치료 표준을 바꿀 정도의 환자 결과 데이터는 없다. 바이오마커와 표적 후보를 함께 제시해 후속 검증 가치가 높다.
Chirality in hydrogels assembled from D- or L-amino acid derivatives regulates immunological responses during diabetic wound healing.
Immunomodulatory biomaterials that perform specific host immune responses have shown great prospects for immunotherapies and regenerative medicine. Although there is a growing recognition of chirality in manipulating cell behavior, the regulatory role of matrix chirality on immune cell function and …
이 연구는 키랄 하이드로겔이 면역반응과 상처 치유를 조절할 수 있음을 보여준다. 다만 핵심 근거는 마우스 모델과 기전 연구이므로 임상 근거는 제한적이다. 플랫폼 개념은 흥미롭지만 상용화까지는 추가 검증이 필요하다.
Caspase-1-targeting siRNA nanoparticles suppress pyroptosis to prevent force-induced root resorption.
Mechanical force-induced hard tissue defects are clinically prevalent, particularly in dentistry. Excessive mechanical stimulation could induce pathological tooth root resorption (RR), which leads to tooth mobility and even tooth loss. This process is closely associated with dysregulated biological …
치과 영역의 기계적 힘 유발 root resorption에 대한 기전과 치료 가능성을 함께 제시한 연구다. 동물모델과 나노입자 전달의 개념증명 수준이므로 임상 근거는 제한적이지만, 표적 치료 전략으로서의 의미는 있다. 상용화 가능성은 있으나 안전성, 전달 효율, 사람 적용 검증이 추가로 필요하다.
Nano-immunomodulators co-activate immunogenic cell death and the cGAS-STING pathway for breast cancer immunotherapy.
Breast cancer generally does not respond to immunotherapy due to its inherently low immunogenicity and insufficient coordination between innate and adaptive immune responses. Here, we demonstrated that concurrent activation of immunogenic cell death (ICD) and the cyclic GMP-AMP synthase-stimulator o…
유방암 면역치료의 저면역원성 문제를 ICD와 cGAS-STING 동시 활성화로 풀려는 점이 의미 있다. 다만 현재 근거는 전임상 마우스 수준이므로 임상적 파급력은 제한적이다. 플랫폼성 나노물질로서 후속 개발 가능성은 있으나 안전성·재현성 검증이 필요하다.
Charge-driven lipid nanoparticle encapsulation of enzymes for enhanced ERT with reduced immunogenicity.
Efficient intracellular delivery of therapeutic enzymes remains a central limitation of protein-based therapies. In lysosomal storage disorders such as Pompe disease, classical enzyme replacement therapy (ERT) is particularly constrained by inefficient delivery to skeletal muscle, limited cellular u…
마우스 기반 전임상 연구로 임상 근거는 제한적이다. 그러나 효소 전달과 면역원성 저감이라는 ERT의 핵심 병목을 동시에 개선해 의미가 있다. 플랫폼 확장성과 재현성을 추가 검증하면 후속 개발 가치가 있다.
A versatile capsule-intravaginal ring platform enables rapid and sustained release of monoclonal antibodies for non-hormonal contraception.
Non-hormonal contraceptives that do not require use immediately before or after intercourse would likely meet the reproductive health needs of millions of women. We previously reported the engineering of MM008, a highly multivalent monoclonal antibody with 10 Fabs against a unique human sperm antige…
사람 적용을 목표로 한 비호르몬 피임 플랫폼의 전임상 검증 연구다. 양 모델에서 장기간 기능과 안전성을 보여 임상 전환 가능성은 있으나, 아직 인간 효능 데이터는 없다. 전달 플랫폼의 확장성도 있어 후속 개발 가치가 있다.
DNA-directed assembly of multivalent lipid nanoparticles for targeted T cell gene delivery.
Lipid nanoparticles (LNPs) are a powerful emerging tool for in vivo T cell engineering to treat diseases ranging from B cell lymphomas and other cancers to autoimmune diseases. Key challenges in designing these therapeutics include achieving both precise cell targeting and efficient mRNA translation…
임상적 의미는 아직 초기 단계로, 인간 데이터가 없어 직접적인 치료 효과를 말하기 어렵다. 다만 T 세포 표적 전달 효율을 높일 수 있는 플랫폼을 제시해 후속 연구 가치가 크다. 상업적으로도 세포치료·유전자전달 분야에서 응용 가능성이 있으나 개발 리스크는 여전히 높다.
Biomaterials-guided nanomedicine for familial adenomatous polyposis: lipid nanopartiscle RNA therapeutics with translational relevance.
Familial adenomatous polyposis (FAP) is a genetic disorder primarily driven by mutations in the adenomatous polyposis coli (APC) gene, leading to hereditary colorectal cancer. Without intervention, FAP almost invariably progresses to colorectal carcinoma. Due to the large molecular weight of APC pro…
전임상 단계이지만 FAP라는 미충족 수요가 큰 질환에서 의미 있는 효능을 보였다. 임상 적용 가능성을 염두에 둔 전달 전략과 안전성 자료가 있어 추적 가치가 높다.
Chelator-guided radiosynthesis, preclinical evaluation, and clinical study of [68Ga]Ga-TRAP-(FAPI)3 for positron emission tomography imaging of tumors.
Tumor visualization based on nuclear medicine molecular imaging techniques offer a robust approach for early malignancy detection, staging, and prognosis assessment. Screening pathological targets is fundamental to advance the development of targeted radiopharmaceuticals. Recently, radiolabeled inhi…
전임상에서 종양 축적과 세포 흡수가 크게 개선된 FAPI 기반 PET 추적자를 제시한 연구다. 환자 1례의 초기 임상 결과가 있어 임상적 의미는 제한적이지만, 추적 가치가 높다. 상용화는 가능성이 있으나 추가 임상 검증이 필요하다.
Cyclic monochalcogen bonds enable improved stability and fine-tuned activation of dimeric prodrug nanoassemblies for potent cancer therapy.
Homodimeric prodrug nanoassemblies (HPNs) have attracted attention as an effective approach to enhance the delivery efficiency of chemotherapeutic drugs. The chemical linkages are critical determinants of the therapeutic performance and safety profile of the HPNs. Previous studies have shown that th…
이 연구는 기존 선형 monochalcogen 결합의 조기 분해 문제를 줄이면서 종양 부위 활성화는 유지한 점이 핵심이다. 다만 전임상 수준이므로 임상적 파급력은 제한적이며, 플랫폼 개념의 신선함과 확장 가능성은 높다.
Endogenous targeting lipid nanoparticles for systemic mRNA delivery to lung cancer tumors.
Systemic delivery of mRNA therapeutics to lung cancer tumors remains challenging despite recent advances in organ-targeting lipid nanoparticles (LNPs). This study introduces novel LNPs, comprising commercially available DC-cholesterol (a cationic derivative of cholesterol) and 113-O12B ionizable lip…
폐종양 표적 mRNA 전달을 위한 새로운 LNP 설계를 제시한 전임상 연구다. 종양 부담 감소와 악액질 개선이 보여 임상 가능성은 있으나, 아직 동물모델 수준이라 검증이 더 필요하다. 기전적 타당성과 플랫폼 확장성은 높아 보인다.
Flowerbed-Inspired Mg-Loaded Scaffold Accelerates Critical-Sized Bone-Defect Repair by Reprogramming the Microenvironment.
The repair and reconstruction of critical-sized bone defects pose substantial clinical challenges, particularly owing to the limited self-healing capacity of the central regions. Inspired by the structure and function of a “flowerbed,” we developed a biomimetic composite scaffold by embedding a magn…
전임상 연구로서 임상 근거는 아직 제한적이다. 그러나 대동물 모델까지 검증되어 골결손 재생 플랫폼으로서의 가능성은 높다. 기전 분석도 비교적 탄탄해 후속 개발 가치가 있다.
Manganese-tannic acid immunomodulators potentiate PDGFRβ CAR-T cell function for additive therapy against liver fibrosis.
Chimeric antigen receptor (CAR)-T cell therapy has achieved considerable success in treating malignant tumors. However, its therapeutic efficacy in hepatic fibrosis remains unclear. The activated hepatic stellate cells (aHSCs) represent a central driver in the initiation and progression of liver fib…
간질성 간섬유화에 대한 CAR-T 기반 치료의 전임상 개념증명 연구다. MT 나노입자가 CAR-T 기능을 높이는 기전까지 제시해 발견 가치가 있다. 다만 인간 데이터가 없어 임상적 파급력은 제한적이다.
β-glucuronidase-triggered ortho-hydroxyl-mediated cyclization strategy for the efficient delivery of phenolic payloads in antibody-drug conjugates.
While the payload landscape of antibody-drug conjugates (ADCs) has diversified beyond amine-containing compounds, the application of potent cytotoxic agents possessing phenolic hydroxyl groups remains restricted. This is primarily due to the scarcity of linker technologies capable of balancing syste…
이 연구는 페놀성 payload를 위한 새로운 ADC 링커 전략을 제시한 전임상 연구다. 종양 미세환경 효소를 이용한 활성화와 우수한 마우스 종양 억제 효과가 있어 기술적 가치는 높다. 다만 인간 임상 근거는 없으므로 임상 영향은 제한적이다.
Biomimetic trident lipid anchoring enables stable neutrophil-based combination therapy.
Anchoring-conjugation strategy, characterized by benign hydrophobic membrane anchoring and swift covalent drug-coupling, has been extensively practiced to attach therapeutic agents to cell surfaces in cell-based combination therapies. However, this approach faces significant challenges in phagocytic…
세포 표면 약물 결합의 안정성을 높인 점이 핵심이다. 다만 인간 임상 근거는 없고 전임상 수준이므로 임상 영향은 제한적이다. 플랫폼 확장 가능성은 있어 발견 가치와 상업 잠재력은 중간 수준이다.
DL-norvaline attenuated HFD-induced metabolic inflammation and dysfunction with integrated pharmacokinetic, biodistribution, and safety evaluation.
Metabolic inflammation is a major contributor to obesity-related metabolic disturbances, yet safe and bioavailable dietary candidates with multi-organ activity remain limited. DL-norvaline, a nonproteinogenic amino acid, was examined for its safety, pharmacokinetic characteristics, tissue distributi…
Safety and immunogenicity of 4CMenB and MenACWY-CRM meningococcal vaccines when administered concomitantly in healthy adolescents: A phase 3b, randomized, observer-blind study.
Meningococcal vaccination of adolescents/young adults is recommended in various countries, including the United States (US). This phase 3b, observer-blind study (NCT04318548) evaluated the safety, reactogenicity, and immunogenicity of serogroup B vaccine, 4CMenB, and quadrivalent conjugate vaccine, …
Fine-tuned phenylboronic acid polymer assembly with tannic acid enables adeno-associated virus to evade and suppress neutralizing antibody responses.
Adeno-associated virus (AAV) has emerged as a promising vector for gene therapy; however, its therapeutic efficacy is often limited by pre-existing and treatment-induced neutralizing antibodies (NAbs). To address this challenge, we developed an AAV-loaded ternary complex through the sequential assem…
이 연구는 AAV의 중화항체 회피를 위한 새로운 폴리머 기반 플랫폼을 제시한 전임상 연구다. 임상 적용 가능성은 있으나 아직 인간 데이터가 없어 clinical impact는 제한적이다. 플랫폼 차원의 차별성과 후속 개발 가능성은 있어 discovery와 commercial 관점에서는 의미가 있다.
Targeting DNA repair with a Pt(IV) prodrug nanoparticle potentiates chemo-immunotherapy for nasopharyngeal carcinoma through cGAS-STING activation.
Cisplatin-based chemotherapy combined with immunotherapy is the standard first-line treatment for advanced nasopharyngeal carcinoma (NPC), but its efficacy is limited by off-target toxicity, platinum resistance, and the immunosuppressive tumor microenvironment (TME). Herein, we report NP2, a reactiv…
전임상 마우스 모델에서만 검증된 연구다. 기전은 흥미롭고 면역활성화까지 연결한 점이 강점이지만, 인간 임상 근거는 아직 없다. 상용화 가능성은 있으나 약물전달, 안전성, 제조 및 임상전환 장벽이 남아 있다.
A copper-based ascorbic acid-activatable gel for postoperative glioblastoma therapy.
Glioblastoma (GBM) is prone to rapid postoperative recurrence, primarily due to its invasive growth pattern and immunosuppressive microenvironment. To combat these challenges, we developed an ascorbic acid (AA)-responsive implantable gel crosslinked by copper ions, denoted as CuTR-gel, for postopera…
수술 후 교모세포종 재발 억제를 목표로 한 국소 주입형 전임상 플랫폼이다. 기전이 독창적이고 면역치료와 세포독성을 결합한 점은 의미가 있으나, 아직 인간 근거는 없다. 상용화 가능성은 있으나 안전성·제조·임상 검증이 많이 남아 있다.
Biomineralized nanoemulsion delivers mRNA for potent cancer immunotherapy.
mRNA vaccines show great promise in cancer immunotherapy by eliciting potent cellular immune responses. Lipid nanoparticles (LNPs), validated through widespread use in COVID-19 vaccination, have become the most widely studied platform. However, their reliance on PEGylated lipids and tendency for hep…
이 연구는 기존 LNP의 한계를 보완하려는 mRNA 전달 플랫폼을 제시한 전임상 연구다. 종양 억제와 면역미세환경 개선이 확인되어 발견적 가치는 높지만, 아직 인간 임상 근거는 없다. 상용화 가능성은 있으나 제조·안전성·임상 검증이 추가로 필요하다.
A cocrystal-based long-acting injectable suspension platform enables tunable drug release.
Long-acting injectable crystal suspensions represent a key technology for enhancing patient adherence in chronic disease management. However, precise modulation of drug release remains a major challenge, often requiring complex dosing regimens. Pharmaceutical cocrystals have emerged as an effective …
Baiting-enhanced extravasation of lipid nanoparticles for targeted co-delivery of decitabine and siTNF-α to the bone marrow niche in leukemia therapy.
Acute myeloid leukemia (AML) remains a fatal malignancy with poor prognosis due to limited drug bioavailability and therapeutic resistance within the protective bone marrow niche. Here, we present a bone marrow-targeted lipid nanoparticle employing a “Bait and Extravasation” approach for the co-deli…
전임상 AML 마우스 모델에서 약물 전달과 미세환경 극복을 동시에 노린 점이 강점이다. 임상 근거는 아직 없지만, 전달 플랫폼과 기전적 설계의 완성도가 높아 후속 연구 가치가 있다.
Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking.
We developed an injectable and transient hydrogel with a programmable lifetime by introducing closed functional loops, specifically gelation and sol transition pathways, within the system. Gelation occurs through the formation of coordination crosslinking between a phosphate ester and its affinity l…
이 연구는 주로 재료공학적 성격이 강하며, 인간 임상 근거는 아직 없다. 다만 체내 효소 반응을 이용해 하이드로겔 수명을 정밀 조절한 점은 신기성이 높고, 약물전달 응용 가능성도 보여준다.
Nationwide Real-World Retrospective Study of Oral Semaglutide Use in Adults Living With Type 2 Diabetes in Finland.
This Finnish nationwide retrospective ‘real-world’ study evaluated the effects of oral semaglutide on glycaemic control, body weight, lipid profile, and liver enzymes in adults living with type 2 diabetes (T2D) and naïve to any GLP-1 receptor agonists in Finland….
Cu2+-chelated epigallocatechin gallate nanoparticle-functionalized hydrogel promotes osteogenesis by inhibiting ferroptosis.
A pathological inflammatory microenvironment can hinder bone regeneration by disrupting the osteogenic differentiation potential of bone marrow-derived mesenchymal stem cells (BMSCs). However, conventional anti-inflammatory therapies alone are insufficient to fully resolve this challenge. Bone defec…
전임상 수준에서 골재생 효능이 매우 강하게 보인다. 다만 사람 대상 검증은 없어 임상적 가치는 제한적이다. 기전과 전달 플랫폼의 조합은 흥미로워 추가 검토 가치가 있다.
Real-World Effectiveness of Risankizumab in Refractory Crohn’s Disease: The RISANCROHN Study From the ENEIDA Registry.
Risankizumab, a selective interleukin-23 p19 inhibitor, has demonstrated efficacy in clinical trials for moderate-to-severe Crohn’s disease, but real-world data in highly refractory populations are limited. We evaluated the short-term effectiveness and outcomes at last follow-up of risankizumab and …
Nano-sized DNase scavenges cell-free DNA for acute lung injury treatment.
Excessive release of cell-free DNA (cf-DNA) from damaged cells activates DNA sensors, triggering robust inflammatory responses and contributing to the pathogenesis of acute lung injury (ALI). To address this, we developed a nano-sized DNase system by conjugating DNase I onto PEGylated bilirubin (BR)…
이 연구는 급성 폐손상에서 cf-DNA를 제거하는 나노 DNase 치료 전략을 제시한 전임상 연구다. 임상 근거는 아직 없지만, 기전과 전달체 설계가 흥미롭고 후속 번역 연구 가치가 있다.
Polydopamine-mediated multi-stage delivery for precise local therapy of Helicobacter pylori-infected gastric ulcers.
The effective treatment of Helicobacter pylori-infected gastric ulcers requires precise local delivery of antibiotics to the deep-seated pathogens within the inflamed tissue. However, the complex gastric environment poses significant biological barriers, necessitating distinct functional requirement…
Safety and Efficacy of Endovascular Thrombectomy for Progressive Anterior Circulation Large Vessel Occlusion Stroke Treated Beyond 24 Hours: A Single-Center Retrospective Cohort Study.
Aimed to compare the clinical efficacy and safety of endovascular thrombectomy (EVT) versus best medical therapy (BMT) in patients with progressive anterior circulation large vessel occlusion (LVO) stroke presenting beyond 24 hours from symptom onset….
Targeted and quantitatively modeled biologic delivery via dual-functional probiotic yeast in inflammatory bowel disease.
Probiotic-based therapies are an emerging class of therapeutic interventions that offer a promising strategy for managing chronic and inflammatory conditions. Here, we engineered a dual-functional probiotic yeast strain, Saccharomyces boulardii, designed to target inflammatory lesions within the gas…
전임상 마우스 모델에서 작동을 입증한 연구다. 임상적 직접성은 낮지만, 표적 미생물 기반 전달 플랫폼이라는 점에서 발견 가치가 높다. 상용화 가능성은 있으나 안전성, 제조, 규제 장벽이 커서 아직은 초기 단계다.
Identification of Chronic Stress-Related Biomarkers for Potential Diagnosis and Treatment of Osteoporosis: An Integrated Multi-omic and Clinical Data Analysis.
The mechanisms through which chronic stress-related genes influence the diagnosis of osteoporosis (OP), where chronic stress serves as a risk factor, remain unclear. This study aimed to identify chronic stress-related biomarkers using multi-omics approaches and explore their potential applications i…
Early pregravid correction of hemostasis assessed by novel biomarkers improves the outcomes of pregnancies in women with bad obstetric history.
Premorbid hypercoagulability causes obstetric complications; therefore, anticoagulation from the preconception period and throughout pregnancy may be beneficial in cases of bad obstetric history (BOH). The aim of the study is to test this hypothesis; 115 patients with BOH and 38 healthy women withou…
MAZ-driven MRPL11 links mitochondrial homeostasis to AKT/mTOR signaling and promotes pancreatic ductal adenocarcinoma progression.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, owing to late diagnosis, rapid progression, and resistance to therapy. Here, we identify mitochondrial ribosomal protein L11 (MRPL11) as a novel oncogenic driver of PDAC. Multi-omics and survival analyses revealed t…
이 연구는 PDAC에서 MRPL11의 종양촉진 역할과 MAZ-MRPL11-AKT/mTOR 축을 제시한 기전 연구다. 임상 근거는 전임상 수준이므로 직접적 환자 적용성은 낮지만, 표적 후보로서의 의미는 있다.
HMGA2 identified via m6A-senescence multi-omics in laryngeal squamous cell carcinoma.
N6-methyladenosine (m6A) modification and cellular senescence have been individually implicated in tumor biology, but the landscape of m6A-related senescence genes in laryngeal squamous cell carcinoma (LSCC) remains underexplored. In this study, we conducted an integrated multi-omics analysis combin…
Obesity history exacerbates liver macrophage-mediated fibrosis via IGFBP7.
Weight regain is a frequent outcome after lifestyle-induced weight loss and is closely linked to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the mechanisms by which prior obesity predisposes to metabolic dysfunction-associated steatohepatitis (MASH) …
비만 병력이 체중 재증가 시 MASH 섬유화를 악화시킬 수 있음을 보여준 전임상 연구다. IGFBP7-대식세포 축은 기전적으로 흥미롭고 표적 가능성도 있으나, 아직 인간 근거는 없다.
Antimicrobial and immune-modulating effects of recombinant pancreatitis-associated protein in the treatment of MRSA-induced severe septic arthritis.
Septic arthritis is a severe infection caused by bacteria directly invading the synovial joints. It leads to inflammatory damage to articular cartilage and may result in significant functional impairment, with a high recurrence rate. The rapid spread of antibiotic-resistant bacterial strains has fur…
Digital Rehabilitation Following Ultrasound-Guided Injection for Chronic Rotator Cuff Injury: Randomized Controlled Trial.
Chronic rotator cuff injuries (CRCIs) often lead to shoulder pain and dysfunction. Although ultrasound-guided injections provide rapid pain relief, subsequent rehabilitation efficacy is often compromised by poor exercise adherence and inaccurate movement execution. Digital therapeutics may enhance p…
In vivo generation of fibrolytic macrophages via LNP-CSF1 mRNA attenuates liver fibrosis.
Liver fibrosis, a common consequence of chronic liver injury, imposes a substantial global health burden. While autologous infusion of ex vivo-induced macrophages has shown therapeutic potential, such cell-based strategies remain limited by high costs and operational complexity, underscoring the nec…
마우스 모델에서 간 섬유화를 완화한 전임상 연구다. 세포치료를 대체할 수 있는 in situ 면역세포 재프로그래밍 전략이라는 점이 의미가 있다. 다만 인간 데이터가 없어 임상적 가치는 아직 제한적이다.
Targeted microwave sensitizers reprogram cancer-associated fibroblasts via nitric oxide delivery to potentiate hepatocellular carcinoma therapy.
Microwave ablation (MWA) has emerged as a locoregional therapeutic modality for the management of various solid tumors. However, MWA often struggles to completely eliminate tumor cells without damaging surrounding healthy tissue. This triggers the persistence of an immunosuppressive microenvironment…
전임상 나노플랫폼 연구로 보이며, 간세포암 MWA의 효율과 면역반응을 높이려는 점이 핵심이다. 기전적 조합은 흥미롭지만 인간 임상 근거는 없어서 임상 영향은 낮다. 다만 플랫폼 확장성과 종양미세환경 재프로그래밍 측면에서 추적 가치는 있다.
Bio-inspired fractal-structured gel-drugs enable enhancing deep tumor penetration for efficient chemotherapy of hepatocellular carcinoma.
Current nanoparticle-based drug delivery systems present significant challenges in treating solid tumors, primarily due to a variety of physiological and pathological barriers that hinder the deep penetration of drugs. Herein, we demonstrate bio-inspired fractal-structured gel-drugs (DOX@HPLA, DHPL)…
전임상 수준의 약물전달 플랫폼 연구다. 간세포암에서 종양 침투와 항암효과를 높였다는 점은 의미가 있으나, 인간 임상 근거는 없다. 구조적 아이디어와 기전은 흥미롭지만 상용화까지는 추가 검증이 많이 필요하다.