📅 2026년 6월 9일 | PubMed 수집 논문
★ 주요 논문 — 이번 수집의 하이라이트
Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial.
Survodutide is a glucagon receptor/glucagon-like peptide-1 receptor dual agonist under investigation for treating obesity and related diseases. The SYNCHRONIZE-MASLD phase 3, randomized, double-blind, placebo-controlled trial included 216 adults (131 female and 85 male) with obesity (defined as a bo…
Targeting Hspd1 attenuates neuroinflammation and promotes functional recovery after intracerebral hemorrhage.
Intracerebral hemorrhage (ICH) triggers a profound neuroinflammatory cascade in which microglial polarization critically influences secondary brain injury and neurological outcomes. Clinical data revealed that Hspd1 expression is significantly elevated in circulating monocytes from ICH patients and …
토픽별 전체 논문
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Survodutide in adults with obesity and metabolic dysfunction-associated steatotic liver disease: SYNCHRONIZE-MASLD, a randomized, double-blind, placebo-controlled phase 3 trial.
Survodutide is a glucagon receptor/glucagon-like peptide-1 receptor dual agonist under investigation for treating obesity and related diseases. The SYNCHRONIZE-MASLD phase 3, randomized, double-blind, placebo-controlled trial included 216 adults (131 female and 85 male) with obesity (defined as a bo…
무작위배정 3상 인간 임상시험으로 임상적 근거가 강하다. 간지방 감소와 체중 감소가 모두 유의하게 나타나 MASLD 치료 후보로서 의미가 크다. 다만 48주로 짧아 조직학적 개선과 장기 안전성은 추가 확인이 필요하다.
Targeting Hspd1 attenuates neuroinflammation and promotes functional recovery after intracerebral hemorrhage.
Intracerebral hemorrhage (ICH) triggers a profound neuroinflammatory cascade in which microglial polarization critically influences secondary brain injury and neurological outcomes. Clinical data revealed that Hspd1 expression is significantly elevated in circulating monocytes from ICH patients and …
임상 환자 데이터와 동물/기전 결과가 함께 제시되어 의미가 있다. 다만 아직 초기 단계로, 실제 치료 적용 가능성은 추가 검증이 필요하다.
Novel BTK inhibitors and degraders for relapsed/refractory CLL/SLL: latest updates from ASH 2025 annual meeting.
Although covalent and non-covalent Bruton tyrosine kinase inhibitors (BTKi) have extended clinical benefit to relapsed/refractory (R/R) and BTKi-resistant chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), there remains an unmet need for additional B-cell receptor (BCR) pathway targe…
Secondary Restless Legs Syndrome during Psychopharmacological Treatment: Real-World Evidence from a Multinational Pharmacovigilance Program.
Secondary Restless Legs Syndrome (RLS) has repeatedly been associated with psychopharmacotherapy, especially antidepressants (ADs) and antipsychotics (APs). However, existing evidence is conflicting in terms of the magnitude of the association as well as the significance of substance classes or indi…
Effectiveness and safety of mirikizumab in patients with moderate-to-severe ulcerative colitis: the miri real multicenter study.
Mirikizumab, an IL-23 p19-targeting monoclonal antibody, is approved for moderate-to-severe ulcerative colitis (UC). Real-world evidence on its effectiveness and safety remains limited. We evaluated its effectiveness and safety in a real-world setting….
Standardized ready-to-use natural deep eutectic solvent-impregnated polypropylene fiber units for robust and high-throughput determination of tyrosine kinase inhibitors in biological fluids.
Therapeutic drug monitoring (TDM) of tyrosine kinase inhibitors (TKIs) is essential for individualized dosing due to their narrow therapeutic windows and pronounced pharmacokinetic variability. However, routine TDM is still hindered by sample preparation strategies that rely on labor-intensive workf…
Integrative Proteomics Reveals Distinct Lipid Metabolic and Gut Microbiota-Associated Antidepressant Mechanisms of Two Herbal Medicines in a Chronic Stress Model.
Depression is a prevalent and disabling mental disorder associated with increased suicide risk and impaired quality of life. Herbal medicines such as Hypericum perforatum L. (St. John’s Wort [SJW]) and Chaihu Shugan San (CSGS) have been widely used to treat depressive symptoms, yet their system-leve…
CRISPR/Cas12a-mediated electrochemiluminescent biosensor integrating Ag modified Co-doped metal-organic frameworks for dual detection of malathion and phorate.
With growing concerns about food safety, the detection of pesticide residues in food has become increasingly important. The mixed organophosphorus pesticides (OPs) formulations are commonly employed to maximize crop production; however, the excessive application of OPs has posed severe threats to fo…
A colorimetric/fluorescent/electrochemical tri-modal biosensor based on dual CRISPR/Cas12a system for detection of microRNA.
The precise detection of tumor markers is crucial for early cancer diagnosis and monitoring. Existing unimodal detection methods are susceptible to interference in complex biological samples, making it difficult to simultaneously achieve high sensitivity and reliability. MicroRNAs (miRNAs), as a key…
Percutaneous Transcatheter Embolization for Recurrent Cerebral Embolism Due to Pulmonary Arteriovenous Malformation.
BACKGROUND Pulmonary arteriovenous malformations (PAVMs) are rare structural vascular abnormalities that create communications between pulmonary arteries and veins, resulting in right-to-left shunts. PAVMs are often asymptomatic; however, patients may exhibit a range of clinical symptoms, including …
A label-free fluorescent aptasensor based on DNA-templated silver nanoclusters and catalytic hairpin assembly for highly specific detection of Escherichia coli O111:B4 lipopolysaccharide.
Escherichia coli O111:B4 is an important diarrheagenic serotype and an indicator of fecal contamination in water quality monitoring. Its specific detection remains challenging because of the high structural similarity among E. coli serotypes and limitations in conventional assays. Serotype-specific …
Lysosome-targeted copper-modulated carbon dots with near-infrared fluorescence imaging and enhanced photodynamic therapy effects.
The excellent biocompatibility and tunable optical properties of carbon dots make them highly promising for applications in photodynamic therapy (PDT). However, effectively enhancing their photodynamic performance remains a significant challenge. This work employed methylene blue and metformin as pr…
Vascular Disease Prospective-Retrospective Observational Registry for Aortic Aneurysm and Peripheral Artery Disease in Korea: Study Rationale and Methodology.
Peripheral artery disease (PAD) and aortic aneurysm (AA) are major manifestations of systemic atherosclerosis. Although they differ in pathophysiology and clinical presentation, they share common risk factors and overlapping biological pathways. However, long-term integrated data encompassing both c…
A multi-omics analysis of a succinylation-associated gene-expression signature in clear cell renal cell carcinoma: prognostic significance and the immune-metabolic microenvironment.
Clear cell renal cell carcinoma (ccRCC) exhibits significant metabolic alterations. Protein succinylation, a metabolite-induced post-translational modification, plays a vital role in cellular metabolism and tumor biology….