2026년 4월 8일 Pubmed Today

The opioid epidemic has led to a devastating loss of life nationwide. Of those dependent on opioids, many individuals desire to quit or reduce use, but their efforts are often unsuccessful given the powerful reinforcing properties associated with opioid drugs, including fentanyl. Here, we developed …

AI 기반 약물설계가 오피오이드 사용장애 후보물질 발굴로 이어졌다는 점에서 발견적 의미가 크다. 다만 환자 치료를 바꿀 수준의 임상 근거는 없고, 상용화까지는 비임상 검증과 임상 전환이 핵심 관문이다.

Cyclin-dependent kinase 16 (CDK16), a serine/threonine protein kinase, is a critical regulator of cell cycle progression, vesicle trafficking, and apoptosis. Its dysregulation is implicated in the progression of aggressive cancers, including triple-negative breast, lung, and prostate cancer, where i…

Timely recognition of oral anticoagulant use is critical in acute stroke but is often hampered by impaired consciousness and unavailable medication history. We investigated whether routinely available coagulation tests, prothrombin time-international normalized ratio and activated partial thrombopla…

Cancer remains a significant global health challenge, necessitating innovative therapeutic strategies. Functional organic luminogens have emerged as a versatile class of biomaterials for cancer theranostics, enabling the integration of diagnostic imaging and therapeutic intervention within a single …

Identifying and understanding cryptic pockets remains a compelling goal in drug discovery, as they can offer new avenues for targeting proteins that are otherwise challenging to modulate. While artificial intelligence (AI) methods for structure prediction have been revolutionary, they have not learn…

Warnings of pathogens manufactured to target a specific ethnic group, so-called genetic bioweapons, have recently received considerable media attention. Genetic bioweapons figure prominently in reports on potential future risks emerging from combining genetic research, artificial intelligence and sy…

This review highlights our group’s systematic approach to integrating molecular docking, pharmacophore modeling, and machine learning methodologies for the rational discovery of bioactive leads. We describe innovative strategies including docking-based data augmentation, ligand-receptor contact fing…

Skin cancer is a prevalent public health problem worldwide, caused by multiple factors like ultraviolet (UV) radiation, environmental toxins, and lifestyle-related risks. Early diagnosis is the key to enhancing patient outcomes, and recent times have seen tremendous development in artificial intelli…

Indoor spaces contain diverse microbial communities that shape human health. These microorganisms are particularly relevant to respiratory diseases, including asthma and allergies. Despite growing recognition of the importance of indoor microbial exposures, research in this field is slowed by differ…

The persistent global burden of viral infections, compounded by the emergence of resistance and suboptimal therapeutic efficacy, underscores the urgency for innovative treatment strategies. Recent viral outbreaks such as COVID-19, Human metapneumovirus (HMPV), Zika, Ebola, Nipah, and various influen…

To evaluate the real-world effectiveness and safety of adjunctive zonisamide in children with developmental epileptic encephalopathy/epileptic encephalopathy (DEE/EE), focusing on younger children and highly drug-resistant cases….

Although its exact mechanism is yet unknown, cervical cancer is a very common malignant tumor in the world. Its growth is strongly linked to metabolic imbalance and tumor microenvironment heterogeneity. Further research is necessary to determine if the natural substance matrine’s multi-targeted anti…

Acute pancreatitis (AP) is without specific drug therapy. We conducted a phase 2b trial of the calcium release-activated calcium channel inhibitor zegocractin, previously found to accelerate recovery of food intake in AP, to determine dose-response, target population, endpoints, safety and tolerabil…

Alzheimer’s Disease (AD) pathology involves much more than just Amyloid- Beta (Aβ) and tau (Tau) deposition. A broad network of Post-Translational Modifications (PTMs) drives pathogenic protein conformations that accelerate neuroinflammation, synaptic dysfunction, aggregation, and trans-neuron…

Recurrent alcohol use is a major determinant of liver-related outcomes in patients recovering from alcohol-associated hepatitis (AH). However, the timing and predictors of return to drinking (RTD) are not well-studied….

CRISPR-Cas systems have been explored for targeted genome editing of several organisms. It is rapid, cost-effective, specific, and versatile technology. It requires expression of multidomain single Cas9 protein and single guide RNA (sgRNA) that targets desired nucleic acids in the presence of a&#xa0…

Gene therapy signifies a transformative revolution in hemophilia care, providing the possibility for sustained endogenous synthesis of coagulation factors and limiting the need for external factor supplementation. Preliminary experiments in hemophilia B via adeno-associated viral (AAV) vectors encou…

The emergence of genome editing using the CRISPR/Cas9 system has opened up new possibilities and significantly improved the potential for long-term gene therapy of beta-thalassemia. In Iran, FSC 36/37 (-T) is one of the most common mutations among affected individuals, with the highest frequency in …

Multiple omics studies on patients with recurrent pregnancy loss (RPL) have deepened the understanding of its pathogenesis. However, few studies have combined multi-omics techniques to provide a more accurate characterization of RPL. This study aims to identify biomarkers with RPL through proteomic …

Multi-omics integration holds considerable promise for advancing disease understanding and improving the performance of biomedical classification tasks. However, existing methods often struggle to comprehensively capture the complex relationships within and between different omics modalities, thereb…

As a pivotal therapeutic approach following surgery, chemoradiotherapy, and molecular targeted therapy, tumor immunotherapy has revolutionized survival outcomes for cancer patients, with immune checkpoint inhibitors (ICIs) demonstrating remarkable efficacy in clinical practice. However, challenges s…

Patient-derived cells (PDCs) and patient-derived organoids (PDOs) are complementary preclinical models widely used in translational cancer research. However, their molecular and functional differences have not been systematically characterized. This study established and analyzed paired PDC and PDO …

Lung cancer is the leading cause of cancer-related mortality worldwide, and non-small cell lung cancer (NSCLC) accounts for the majority of cases. Alterations in metabolic activities play important roles in NSCLC development, wherein related genes and metabolites interact with each other, involving …

Tumor heterogeneity challenges the accuracy of existing prognostic models for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Prognostic models that correct for tumor heterogeneity remain unexplored….

BackgroundVascular cognitive impairment (VCI) is the second most common dementia etiology after Alzheimer’s disease. However, plasma biomarkers of VCI remain insufficiently validated.ObjectiveWe aimed to identify plasma biomarker candidates for VCI by using integrated multi-omics analyses.MethodsWe …

What is this summary about?There are only a few current treatment options for people with newly diagnosed advanced or recurrent endometrial cancer (cancer that has returned). The DUO-E study is testing an immunotherapy, durvalumab, and a targeted therapy, olaparib, in people with newly diagnosed adv…

진행성 자궁내막암에서 면역항암제 기반 유지전략이 실제 임상 선택지로 자리잡을 가능성을 보여준 결과이다. 다만 평문 요약 형태라 효과 크기와 비교 기준의 세부 해석이 제한적이며, 실제 진료 변화는 세부 하위군과 가이드라인 반영 속도에 달려 있다.

Hypoalbuminemia is a common clinical biomarker associated with poor outcomes in cancer patients. While it correlates with resistance to immune checkpoint inhibitors (ICIs), the direct functional role and underlying mechanisms in driving immunotherapy resistance remain unclear. In our study, we demon…

기전적 의미는 분명하지만 환자에서의 검증이 없어 임상 변화 가능성은 아직 제한적이다. 다만 영양 상태와 면역치료 반응을 연결한 점은 후속 임상 연구의 출발점으로 가치가 있다.

Astatine-211 (211At) is a promising alpha emitter for cancer treatment, wherein tumor-selective accumulation is pivotal due to its short path length. While sodium ascorbate (SA) successfully protects radioactive antibodies from reactive oxygen species (ROS)-induced denaturation, it does not reduce 2…

Lung adenocarcinoma (LUAD) has limited therapeutic targets and poor survival. Noncanonical open reading frames (ORFs) in long noncoding RNAs (lncRNAs) may encode functional microproteins, but their roles in LUAD remain unclear. This study aims to characterise the LINC00973-encoded microprotein L3EMP…

폐선암에서 비정형 ORF가 기능성 미세단백질을 만들고 종양 진행을 유도한다는 점을 보여준 기전 연구이다. 새로운 표적 후보를 제시해 학술적 가치는 높지만, 실제 환자 치료 변화로 이어지려면 추가 검증과 약물화 가능성 평가가 필요하다.

Dynamic nanomachines capable of selectively engaging tumor-infiltrating immune cells and modulating their intrinsic functions represent a critical unmet need in cancer immunotherapy. Here, we develop an intelligent DNA nanomachine that selectively targets dendritic cells (DCs) within the tumor micro…

종양 미세환경에서 선택적으로 작동하는 DNA 나노머신과 당화 조절을 결합한 점이 신선하다. 다만 현재는 마우스 수준의 개념 증명에 머물러 있어 환자 치료 변화로 이어지기까지는 추가 검증이 필요하다.

Antibody drug conjugates (ADCs) targeting TROP-2 and cMET are entering clinical trials in NSCLC. Their translation depends on reliable biomarker assessment, a task still dominated by subjective visual scoring and inconsistent reproducibility….

Renal cell carcinoma (RCC) typically shows resistance to immunotherapy and is associated with poor prognosis. Recent studies have revealed a role for DNA methylation in immune infiltration in different cancers, but its pattern in RCC is not well understood. In this study, we analyzed the relationshi…

The local immune effects of cancer radiotherapy remain poorly characterized in humans due to limited access to irradiated tissue. Mechanistic insights largely derive from preclinical models employing tumor-intact, neoadjuvant-like settings. Here, we present real-world immunoprofiling data from breas…

Inhibitory receptors (IRs) such as CTLA-4, PD-1, LAG3, TIM-3, and TIGIT are critical regulators of immune homeostasis, functioning to restrain excessive immune activation and prevent autoimmunity. While the blockade of IRs has transformed cancer immunotherapy by reinvigorating antitumor T cell respo…

Clear cell renal cell carcinoma (ccRCC) exhibits marked metabolic reprogramming, and the unfolded protein response (UPR) plays a crucial role in stress adaptation and immune regulation; however, its underlying mechanisms remain unclear….

We characterized features of immune checkpoint inhibitor (ICI) esophagitis….

CAR-T cell therapy has led to remarkable advances in the outcomes of patients with acute lymphoblastic leukemia (ALL), B cell lymphomas, and multiple myeloma. Given these successes in hematologic malignancies, extensive efforts are now focused on developing CAR-T cell therapies to treat solid tumors…

Despite strong evidence and guidelines supporting prophylactic anticoagulation for ambulatory patients with cancer starting systemic cancer-directed therapy who are at high risk of venous thromboembolism (VTE), uptake in practice is limited. We evaluated the real-world impact of prophylactic anticoa…

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers and has been a popular area of research in the field of oncology. The p53 protein, encoded by the TP53 gene, not only binds to many targeted genes but also regulates apoptosis, autophagy, cell cycle arrest, metabolis…

Immunotherapy harnesses the patient’s immune system to recognize and eliminate malignant cells and constitutes the forefront of cancer therapies. Notwithstanding, intrinsic and acquired immunotherapy resistance mechanisms operating within the tumor microenvironment remain a limitation to achieving d…

The Radiation Oncology-Biology Integration Network (ROBIN) initiative addresses critical gaps in radiation oncology by integrating advanced biological research, technological innovation, and clinical practice. ROBIN leverages “omics” technologies, data science, and integrative analyses to elucidate …

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality, and many patients derive limited benefit from current systemic therapies. Until now, clinical and translational efforts have largely focused on recurrent genomic alterations in the Kelch-like ECH-associated protein 1-nuc…

The optimal sequence of administering immune checkpoint inhibitors (ICIs) and chemotherapy in advanced esophageal cancer (EC) and gastric cancer (GC) remains to be established. Understanding how this sequencing affects overall survival (OS) is crucial for optimizing treatment strategies….

Advances in understanding tumor heterogeneity and the tumor microenvironment (TME) have ushered in a new era of targeted and immunotherapy. Both targeted and immunotherapy mainly rely on the use of specific antibodies against the tumor targets. Although monoclonal antibodies (mAbs) have achieved tre…

Plasmonic nanoplatforms have emerged as a powerful and versatile class of cancer theranostic agents, enabling the seamless integration of diagnostic imaging and therapeutic intervention within a single nanoscale system. By exploiting localized surface plasmon resonance (LSPR), these nanostructures c…

Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are among the backbones of treatment for relapsed/refractory multiple myeloma (RRMM). Beyond current standard-of-care regimens, the roles of mAbs/ADCs are evolving associated with advances in first-line therapy, emerging data on additi…

BACKGROUND Mycosis fungoides, the most common cutaneous T-cell lymphoma, can transform into large cell lymphoma in some cases, leading to worse outcomes and reduced life expectancy. CASE REPORT We report the case of a 38-year-old Brazilian man with a history of multiple skin lesions refractory to me…

Immunotherapy resistance represents a major unmet clinical need for patients with metastatic non-small cell lung cancer (NSCLC). Preclinical studies have identified PCSK9 as an immunosuppressive regulator of antigen presentation, providing a compelling rationale for therapeutic PCSK9 inhibition as a…

Mucosal melanoma (MM) represents a rare malignancy in Caucasian populations but constitutes one of the predominant melanoma subtypes among non-Caucasian ethnic groups. Due to its anatomic occult nature, a significant proportion of patients with MM present with advanced-stage disease at diagnosis. Ch…

Glioblastoma (GBM), the most common and aggressive primary brain tumor of the central nervous system, is characterized by significant heterogeneity and rapid growth. Its high vascularity, deep infiltration into the brain parenchyma, and indistinct boundaries limit the success of conventional treatme…

The advent of immune checkpoint inhibitors (ICIs) has transformed the treatment landscape of various malignancies. While these therapies have demonstrated significant efficacy, they are often accompanied by immune-related adverse events (irAEs). Among these, hematologic immune-related toxicities are…

Despite immunotherapy progress in cancer treatment, clinical success is still hindered by challenges, such as systemic off-target effects, adverse events, and low immune response. Precision delivery can resolve these issues by targeting and controlling the delivery of immunotherapy agents to cancer …

Dementia, cardiovascular disease (CVD), and functional impairment (FI) often co-occur in aging populations, with abdominal obesity as a shared modifiable risk factor. The long-term impact of abdominal obesity on these comorbidities is unclear. We projected the 30-year burden of dementia, FI, and CVD…

Ginsenosides, a class of bioactive substances, exhibit multi targets and notable anti-aging properties. However, their application as functional food ingredients is still limited. This review begins by examining the research advancements related to key drivers of aging, including mitochondrial dysfu…

Here, for the first time, we propose a thermal-scanning fluorescence spectroscopy (TSFS) method for the rapid identification of yeast. In the method, SYBR Green I (a dsDNA-specific nucleic acid dye) was used as the fluorescence probe to trace physiological changes in yeast cells induced by temperatu…

Against the backdrop of accelerating population aging worldwide, promoting well-being among older populations has emerged as a critical objective for achieving healthy aging. Community-based aged care services (CACS) represent a key strategy to complement informal kinship-based support and strengthe…

The 12th Aging Research and Drug Discovery (ARDD) meeting convened at the University of Copenhagen, presenting a comprehensive overview of recent advancements in the biology of aging. A central theme across sessions was the field’s gradual shift from descriptive, correlational studies to mechanistic…

Interest in fasting-based dietary interventions to improve metabolic health is growing. Caloric restriction (CR) with one meal per day includes an extended fasting component that contributes to its metabolic and longevity benefits, yet the specific role of fasting within CR remains unclear. Here, we…

Chlorogenic acid (CGA) and taurine are well-known antioxidant compounds reported to reduce skin cellular senescence. However, the biological mechanisms underlying their skin-protective effects remain unclear….

To improve the clinical outcomes and long-term durability of polymethyl methacrylate (PMMA) denture-based resins, they have undergone several developments and changes in their chemical composition to enhance their mechanical properties, including reinforcing them with natural fibers….

The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) is the first large Southeast Asian randomized controlled trial of multidomain lifestyle interventions in older adults at increased dementia risk….

The rising prevalence of aging-associated chronic conditions underscores the need for interventions that promote healthy aging. In this study, a low-molecular-weight polysaccharide (PSP-1-1, 2.7 kDa) was isolated from steamed Polygonatum sibiricum using bioactivity-guided purification and struc…

NAFLD is a rising health problem worldwide with unsatisfied therapies. Curcumin has an ameliorative but limited effect on NAFLD due to its low water solubility. In this study, we innovatively establish the high-PC-content liposome-loaded curcumin (hPLipo/Cur) with liver-targeting properties for NAFL…

Heart failure (HF) remains a highly prevalent condition with current therapeutic options, five-year survival remains at fifty percent. Diseased cardiomyocytes have been demonstrated to exhibit telomeric shortening and through DNA damage response activation leads to mitochondria dysfunction. How the …

The intrinsic resistance of tumor cells to apoptosis frequently results in chemoresistance and therapeutic failure in clinical settings. The main active ingredients of traditional Chinese medicine, in combination with chemotherapy drugs, have become one of the effective treatment methods to overcome…

Glutathione (GSH), the most abundant intracellular thiol-containing antioxidant, plays a pivotal role in cellular metabolism and redox homeostasis. Its critical involvement in cancer and neurodegenerative diseases has made it an important target for thiol detection systems. In this work, we report t…

Alzheimer’s disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau protein. In recent years, two cellular processes have emerged as pivotal drivers of neurodegeneration in AD: mitophagy, t…

Dyslipidemia, characterized by an excessive amount of lipids in the bloodstream, is a significant risk factor for metabolic disorders and cardiovascular diseases (CVDs). Maternal supraphysiological hypercholesterolemia (MSPH) is associated with increased maternal levels of total cholesterol (TC) and…

Cardiomyopathy is a disease unique to the heart muscle that increases a patient’s risk of death due to heart failure, contrary to vascular conditions. Cellular powerhouses called mitochondria produce oxygen species that are reactive, that may damage both the mitochondria as well as the heart muscle …