2026년 4월 6일 Pubmed Today

The treatment paradigm for lymphoma, a highly heterogeneous group of hematologic malignancies, has been revolutionized by the development of therapies targeting oncogenic signaling pathways. This shift from conventional chemotherapy to precision medicine is driven by a deep molecular understanding o…

림프종 치료의 분자표적화가 임상적으로 중요한 전환점을 만들었다는 점을 잘 정리한 리뷰이다. 다만 새로운 임상 데이터가 아니라 기존 근거를 종합한 글이어서 즉각적인 변화보다는 해석과 방향 제시에 더 가깝다. 상업적 의미는 크지만, 구체적 제품이나 파이프라인 정보가 없어 추가 맥락 확인이 필요하다.

Hyperuricemia is a well-established direct trigger of gouty arthritis. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid production, represents a core therapeutic target for gout. Although XO inhibitors like allopurinol and febuxostat are widely-used clinically, their limitations, includi…

Geographical traceability is crucial to ensuring consistent quality of Paris polyphylla var. yunnanensis (PPY) from different regions. In this study, a multi-dimension FT-MIR and NIR spectroscopy, data fusion combined with machine learning were used for identifying PPY qualitatively and quantitative…

Environmental monitoring has revealed the presence of Veterinary Pharmaceuticals (VPs) in surface waters, groundwater, manure, soils and treated drinking water. The soil degradation half-life (DT50) is a key indication for assessing chemical risks. To address this issue, we developed robust in silic…

Serum bile acids (BAs) emerge as risk factors for cancer, but their roles in colorectal cancer (CRC) remain unclear. We show that glycocholic acid (GCA), a primary BA, is elevated in the serum of CRC patients. In a mouse CRC model, GCA promotes tumor programmed death-ligand 1 (PD-L1) expression in t…

대장암에서 혈중 glycocholic acid가 면역치료 저항성을 높이는 기전을 제시한 연구이다. 마우스 수준의 기전 규명과 병용 가능성을 보여 의미는 있으나, 실제 환자 치료를 바꿀 임상 근거는 아직 부족하다. FXR 표적화와 GCA 고농도 환자 선별의 임상·사업화 가능성은 추가 검토가 필요하다.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of T-cell precursors. Although the survival rates have improved with the use of intensive chemotherapy, the emergence of relapse as well as treatment-related morbidity and mortality remain major challenges. Novel treatment appro…

Radiopharmaceutical therapy (RPT), the administration of a radioactive element coupled with a targeting vector, is one of the most promising innovations in oncology, supported by clinical trials. A theranostic approach-the pairing of diagnostic and therapeutic RPTs sharing the same target-facilitate…

Intravesical instillation of bacillus Calmette-Guérin (BCG) remains the standard-of-care immunotherapy for high-risk nonmuscle-invasive bladder cancer (NMIBC). However, its clinical efficacy is frequently compromised by rapid drug washout resulting from intermittent bladder voiding, whereas int…

Mismatch repair (MMR) status is a critical predictive biomarker for immune checkpoint inhibitor (ICI) efficacy in colorectal cancer (CRC); however, direct in vivo comparisons of ICI responsiveness between MMR-deficient (dMMR) and MMR-proficient (pMMR) tumors within the same patient are exceedingly r…

Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related deaths worldwide, and its complex tumor microenvironment (TME) is a key barrier to treatment. PANoptosis is a novel programmed cell death mechanism that integrates features of pyroptosis, apoptosis, and necroptosis. However, i…

Peritoneal metastases (PM) remain a major clinical challenge, marked by poor prognosis and a profoundly immunosuppressive tumor microenvironment. Toll-like receptor (TLR) agonists are particularly attractive due to their ability to activate both innate and adaptive immunity, effectively converting ‘…

Colorectal cancer (CRC) is the third most frequently diagnosed malignancy worldwide and the second leading cause of cancer-related mortality. Despite immune checkpoint inhibitors improving outcomes for patients with microsatellite instability high (MSI-H) CRC, their effectiveness against microsatell…

Pancreatic ductal adenocarcinoma (PDAC) has a poor survival rate and limited treatments. Agonistic CD40 antibodies are promising, but clinical trials have shown only modest efficacy and significant hepatotoxicity. We previously reported that IL-1 pathway blockade enhances CD40 agonist efficacy …

Pancreatic cancer remains one of the most lethal cancers of the 21st century due to extensive metabolic reprogramming and a highly adaptable tumor microenvironment that fosters relentless growth and resistance to treatment. Molecular docking studies targeted on malic enzyme facilitate the discovery …

Colorectal cancer (CRC) employs immune evasion strategies, particularly through the expression of immune checkpoint ligands, including PD-L1. These ligands interact with inhibitory receptors, including programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), w…

Extensive-stage small cell lung cancer (ES-SCLC) carries a poor prognosis. Although first-line chemoimmunotherapy (IO+ChT) is standard, evidence in elderly patients (≥70 years) and the role of thoracic radiotherapy (TRT) remain limited….

Extracellular matrix (ECM), once regarded as a passive structural scaffold, is now recognized as a key hallmark of aging. In the context of female reproductive aging, ECM remodeling acts as a pivotal driver of functional deterioration. This review outlines how age-associated ECM alterations, includi…

Parkinson’s disease (PD) is a progressive degenerative neuronal disorder that involves the selective loss of dopaminergic neurons in the substantia nigra, resulting in severe motor and non-motor impairments. Key pathological hallmarks include the accumulation of misfolded α-synuclein and mitoc…

파킨슨병의 염증성 병태생리를 cGAS-STING 축으로 정리한 리뷰 성격의 논문이다. 기전적 통찰은 의미가 있으나 환자 치료를 바꿀 직접 근거는 아직 없으며, 실제 약물 개발 파이프라인과 연결되는지 추가 확인이 필요하다.

Mitochondrial homeostasis is regulated by processes such as biogenesis, dynamics, and mitophagy, and is essential for maintaining cardiac function while preserving structural integrity, energy supply, and redox balance. Given their high reliance on mitochondrial adenosine triphosphate generation, ca…