AI and biotech
Cellular membranes serve as selective barriers, and membrane permeability is crucial for drug pharmacokinetics. While in vitro and in vivo methods exist, predicting and designing membrane permeability remains challenging. We developed a thermodynamics-based deep learning framework to analyze the str…
막 투과성 예측과 최적화라는 오래된 문제에 대해 해석 가능한 계산 프레임워크를 제시했다. 멜라토닌 유도체 MT-A2의 비강 흡수와 뇌 체류 개선은 흥미롭지만, 아직은 전임상 개념검증에 가깝다. 약물 설계 플랫폼으로 확장될 가능성은 있으나 실제 환자 치료 변화까지는 추가 검증이 필요하다.
Generative design and machine learning are increasingly prevalent in medicinal chemistry. To pilot the comprehensive use of automated molecular design on a project, the BRADSHAW platform was used to optimize a series of inhibitors of Endoplasmic Reticulum Aminopeptidase 1 (ERAP1), an emerging target…
Self-assembled herbal bioactive materials (SAHBMs) represent a rapidly advancing frontier integrating phytochemistry, supramolecular chemistry, and biomedical engineering. By leveraging the intrinsic pharmacological activity and self-organization of herbal compounds, SAHBMs offer improved solubility…
Artificial intelligence (AI)-driven molecular property prediction holds significant potential to accelerate drug discovery, yet the development of robust models is hindered by scarce, high-quality data and the diversity of prediction tasks. Although self-supervised learning (SSL), especially contras…
G protein-coupled receptors (GPCRs) are involved in most human physiological processes and one of the largest families of approved drug-targeted proteins. Heterotrimeric Gαβɣ proteins bind to the intracellular cavity of the activated receptor mainly through the C-terminal α5 …
ProQSAR: A modular and reproducible framework for small-data QSAR modeling with fit-and-use models.
2026-04-22
Quantitative structure-activity relationship (QSAR) models are central to computer-aided drug discovery and predictive toxicology, but practical adoption is often impeded by ad-hoc tooling, inconsistent validation protocols, and poor reproducibility….
Certain characteristics, such as high heterogeneity, a complex tumor microenvironment, metastatic potential, and drug resistance, render Lung cancer (LC) a formidable challenge for clinical management. With rapid advancements in high-throughput sequencing, medical imaging, and digital pathology tech…
Drug discovery
The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hopping strategy, pyrimidine- and 1,4-diazepine-fused…
기전적으로는 비만 치료 후보로서 의미 있는 전진이지만, 현재 공개된 정보만으로는 임상적 변화를 판단하기 어렵다. 전임상 효능과 초기 임상 진입은 확인됐으나, 실제 체중감량 효과와 안전성의 크기가 핵심이다. 상업적 가치는 적응증 규모가 크지만 경쟁이 치열해 차별화 데이터가 필요하다.
Gene editing
The 1717-1G>A is a prevalent splicing mutation causing cystic fibrosis (CF) for which no pharmacological treatments have been approved. This mutation disrupts a canonical 3′ AG splice acceptor site in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, leading to severe RNA missp…
희귀 CF 변이에 대해 영구적 유전자 교정 가능성을 보여준 점이 핵심이다. 다만 현재 단계는 세포와 오가노이드 수준의 번역 연구로, 실제 치료 표준을 바꿀 근거는 아직 부족하다. 플랫폼 자체의 확장성과 오프타깃·전달 효율이 향후 가치 판단의 관건이다.
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β-cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long-term comp…
Genomics
Urinary proteomics has swiftly emerged as a formidable tool for the identification of non-invasive biomarkers and the surveillance of diseases. The progression in high-resolution mass spectrometry and data-independent acquisition techniques has facilitated the urinary proteome in providing detailed …
High-throughput proteomics enables detailed molecular phenotyping but poses challenges for predictive modeling and interpretation due to high dimensionality, sparsity, and nonlinear interactions. Biologically informed neural networks (BINNs) address these challenges by embedding pathway knowledge in…
Plasma proteomics serves as the cornerstone of clinical biomarker development, yet standalone profiling is plagued by three critical bottlenecks: poor detection of low-abundance proteins, overlapping signals across pathologically similar diseases, and the lack of upstream/downstream molecular contex…
Immunotherapy
The major barrier to clinical translation of αCD137 immunotherapy is separating antitumor efficacy from hepatotoxicity driven by IFN-γ-producing CD8 T cells. We propose a strategy to limit toxicity by promoting contraction of excessively expanded CD8 T cells. We identify CD11c+KLRG1+ eff…
간독성의 원인을 특정 CD8 T 세포 아형과 LTβR-FRC 축으로 연결해 면역항암제 독성 조절의 새 표적을 제시했다. 다만 아직은 기전 중심의 전임상 단계로, 실제 환자 치료를 바꾸려면 LTβR 길항제의 약물화와 임상 검증이 필요하다.
Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in cancer treatment. Nevertheless, most patients receiving CAR T cells relapse within 5 years of treatment. CAR-mediated trogocytosis (CMT) is a potential tumor escape mechanism in which cell surface proteins transfer from …
CAR T 세포 기능 저하의 원인을 구체적으로 규명하고 이를 약물로 조절할 수 있음을 보여준 점이 의미 있다. 다만 환자 치료를 바꿀 수준의 임상 근거는 없고, 실제 적용을 위해서는 안전성·효능·제조 공정 영향까지 추가 검증이 필요하다.
Immunotherapy has emerged as a first-line treatment for patients with advanced non-small cell lung cancer (NSCLC), but over half of patients fail to benefit, largely due to tumor heterogeneity and a complex tumor microenvironment. Here, we demonstrate that fibrinogen-like protein 1 (FGL1), a recentl…
FGL1의 번역후 조절과 면역회피를 연결한 기전이 명확해 발견 가치가 높다. 다만 실제 환자 치료로 이어지려면 병용요법의 임상 재현성과 FGL1 고발현 환자 선별 전략이 먼저 검증되어야 한다.
VCAR33, a donor-derived CD33-directed chimeric antigen receptor T-cell (CAR T) product, was developed to decrease relapse of high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after allogeneic hematopoietic cell transplantation (alloHCT). We describe preclinical characterizatio…
As a promising cancer immunotherapeutic agent, oncolytic viruses (OV) can specifically kill tumor cells and elicit systemic antitumor immune responses. However, the intrinsic resistance of tumors to oncolytic virotherapy severely limits its therapeutic efficacy. This study identified phospholipase C…
In a real-world analysis of brexucabtagene autoleucel recipients with relapsed/refractory B-cell acute lymphoblastic leukemia (N = 278), lack of response to prior blinatumomab correlates with significantly worse following chimeric antigen receptor T-cell therapy outcomes….
Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences the risk of acute myeloid leukemia.
2026-04-23
Acute myeloid leukemia (AML) is a complex hematologic malignancy with multiple disease subgroups defined by somatic mutations and heterogeneous outcomes. Although genome-wide association studies (GWAS) have identified a small number of common genetic variants influencing AML risk, the heritable comp…
Targeted and immune-based therapies, such as PD-1/PD-L1 inhibitors, have become standard treatments for advanced non-small cell lung cancer (NSCLC). However, accurately identifying patients who benefit from these therapies remains challenging due to tumor heterogeneity and variability in PD-L1 stain…
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs), with acute interstitial nephritis (ICI-AIN) being the most common irAE. While the exact mechanism remains unclear, upregulation of IFN-γ and TNF-α pathways has been implicated. This study used a humanize…
DYRK1A enhances antitumor immunity in type 1 conventional dendritic cells via mTORC1 activation.
2026-04-23
Type 1 conventional dendritic cells (cDC1s) play an integral role in mediating immune responses and maintaining homeostasis, yet the molecular mechanisms underlying their functions remain poorly understood. In this study, we identified dual-specificity tyrosine phosphorylation-regulated kinase 1A (D…
cDC1 면역 기능을 조절하는 상위 신호축을 제시해 면역항암제 병용 전략의 단서를 제공했다. 다만 현재는 전임상 기전 수준이며, 환자 치료를 바꿀 근거는 아직 부족하다.
Neoadjuvant immune checkpoint blockade (ICB) combined with chemotherapy has demonstrated higher response rates than chemotherapy alone in resectable esophageal squamous cell carcinoma (ESCC). Although tumor microenvironment (TME) features associated with treatment response have been studied in the c…
Radiotherapy (RT) represents a potent approach to activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway. However, this immune activation is typically transient and insufficient for long-term tumor control. To overcome this limitation, we developed SCYS-P@MnCO, an…
Prostate-specific membrane antigen (PSMA) is an attractive target for detection and treatment of prostate cancer because of its high, selective expression in tumors. However, PSMA-targeted antibody-drug conjugates (ADCs) have seen limited clinical efficacy compared with small-molecule radiopharmaceu…
An 82-year-old man presented with 4 months of fluctuating diagonal binocular diplopia and progressive bilateral ptosis. Examination in the strabismus clinic revealed variable ptosis and ophthalmoplegia in multiple gaze directions, with a large-angle esotropia and left hypotropia. What would you do n…
Longevity
DNA variants modulate mortality risks across an entire lifespan but their dynamic age-dependent effects have not been resolved in any species for either sex. Here we mapped variants that shape mortality using an actuarial approach, starting with a base population of 6,438 pubescent mice and ending w…
노화의 유전적 trade-off를 연령과 성별에 따라 분해해 보여준 점이 핵심 성과이다. 다만 생쥐 기반의 기초 연구로서 인간 치료 변화는 아직 멀고, 실제 개입 표적로 이어질지 추가 검증이 필요하다.
Mitochondria
Disturbances in energy metabolism are a key pathophysiological feature of major depressive disorder (MDD). The gut microbiota, as a critical regulator of host metabolism, may influence systemic energy homeostasis and contribute to depression. To investigate this, we performed a multi-omics analysis …
장내미생물과 중추 에너지대사 이상을 연결한 점이 인상적이며, 우울증 병태생리 이해를 넓혔다. 다만 환자 치료를 바꿀 수준의 임상 근거는 아직 없고, 자가 FMT의 재현성·안전성·실행 가능성을 확인하는 후속 임상이 필요하다.
Enterovirus-induced cleavage of Mitofusin 2 generates mitophagosomes for enveloped virion release.
2026-04-22
Enterovirus D68 (EV-D68) is a plus-strand RNA virus that primarily causes respiratory infections in infants but, in rare cases, has been associated with the pediatric paralytic disease acute flaccid myelitis. We previously demonstrated that EV-D68 induces nonselective autophagy for its benefit. Here…
숙주 미토콘드리아 역학을 바이러스 방출과 연결한 점이 핵심 성과이다. 다만 치료 전환까지는 표적 검증, 범용성 확인, 약물화 가능성 평가가 더 필요하다.
Triple-negative breast cancer (TNBC) poses a severe clinical challenge due to high recurrence, metastasis, and chemoresistance. To address this, high-index facet (1 1 3) -distorted lanthanum cuprate (LCO) nanosheets are established. Ultrasound (US) activated LCO and amplified tumor suppression via t…
Friedreich’s Ataxia (FRDA) is an early onset hereditary disorder with a strong neurodegenerative component caused by repeat expansions on the gene encoding for frataxin (FXN) that result in FXN deficiency. This deficit has been linked to a cascade of biochemical alterations, including mitochondrial …
Moderate hyperoxia (30%-60% O2) in premature infants promotes bronchial airway hyperresponsiveness (AHR) via airway smooth muscle (ASM), a key regulator of bronchoconstriction, bronchodilation, and remodeling. Understanding how O2 exposure drives long-term bronchial changes in prematurity is critica…