2026년 4월 23일 Pubmed Today

Cancer remains one of the leading causes of death worldwide and continues to pose a serious public health challenge. The limited success of many current treatments-often due to toxicity, poor selectivity, and the development of drug resistance-highlights the need for new and more effective therapeut…

Idiopathic Pulmonary Fibrosis (IPF) is a severely irreversible chronic disease affecting approximately 3 million individuals worldwide, with its pathogenic mechanisms remaining incompletely elucidated. Currently, treatment options of IPF are very limited, with only two FDA-approved drugs. The develo…

This research offers an in-depth analysis of electro-osmotically induced, immiscible bio-convective flow of urine incorporated with five different nanoparticles (NPs) and actively motile microorganisms within a bio-reactive microchannel, subjected to electromagnetic field effects. The model accounts…

Protein-protein interactions (PPIs) govern essential cellular processes, such as signal transduction, enzymatic catalysis, and the formation of macromolecular complexes, but their broad and dynamic interfaces often lack deep binding pockets, making it difficult for them to target conventional small …

Oral medications are commonly used in the treatment of breast cancer (BC), despite high rates of nonadherence. As adherence is fundamental for optimal treatment, finding ways to effectively improve it is important. Artificial intelligence (AI) is being widely applied to health care….

The rapid development of DNA- and RNA-editing tools (collectively referred to as gene editing technologies) has caused a paradigm shift in the treatment of human diseases from symptomatic treatment to precision-based medicine. Both DNA-based and RNA-based editing systems, including Clustered Regular…

Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, reflecting a persistent gap between clinical phenotyping and the molecular mechanisms that govern disease initiation, progression, and inter-individual variability. Recent advances in emerging technologies hav…

Soft tissue sarcomas, particularly complex karyotype sarcomas (CKS), are characterized as “immunologically cold” malignancies driven by structural instability rather than a high tumor mutational burden (TMB). Public “legacy” cohorts are a useful resource to uncover immunotherapy biomarkers. This stu…

The microbiome is increasingly recognized as a key factor in health. Intestinal microbiota modulates gut homeostasis via a range of diverse metabolites. In particular, molecules such as short-chain fatty acids (SCFAs), the microbial fermentation products of dietary fiber, have been established to be…

Hormone-dependent cancers such as prostate, breast, and endometrial carcinomas rely on nuclear hormone receptors to sustain lineage identity and growth. Therapies targeting androgen, estrogen, or progesterone signaling are initially effective but ultimately impose selective pressures that drive resi…

Understanding the heterogeneous nature of Parkinson’s disease is crucial for improving diagnostic and treatment strategies that benefit distinct patient subgroups. Genome-scale metabolic models (GEMs) comprising biochemical reactions and corresponding genes provide powerful frameworks for such inves…

To compare targeted immunotherapy plus adjuvant transarterial chemoembolization (TACE) versus TACE alone in patients with borderline resectable hepatocellular carcinoma (BR-HCC). 297 BR-HCC patients who underwent liver resection were included. Among them, 86 patients received perioperative targeted …

The modulation of immune checkpoint activity exerts profound impacts on tumor immunotherapy. However, the interfere of mature immune checkpoints encounter efficacy challenges in solid tumors, which underlies a critical barrier in clinical translation of multiple potential targets. Herein, we propose…

Messenger RNA (mRNA) vaccines have transformed cancer immunotherapy, yet delayed immune activation, multi-dose requirements, and poor efficacy in immunosuppressive tumor microenvironments (TMEs) hinder current platforms. Here, a structurally stabilized lipopolymer nanoparticle (LPNP) platform is pro…

Oncogenic alterations in MET represent therapeutically actionable driver alterations in non-small cell lung cancers (NSCLC). Among these, MET fusions are rare, occurring in approximately 0.1-0.3% of NSCLC. We report the case of a 52-year-old woman with metastatic, TTF1-positive lung adenocarcinoma h…

Most membrane-bound organelles have been linked to the initiation and execution of ferroptosis. However, the role of the Golgi apparatus and its resident proteins in ferroptosis remain elusive. Here we show that ferroptosis inducer triggers rapid oxidation of Golgi membrane lipids in the early phase…

The microbiome is a key regulator of host homeostasis and immune activity, in part through the production of metabolites. These microbiota-derived metabolites can modulate both the innate and adaptive immune system, as well as directly target tumour cells, thereby regulating anti-tumour immunity and…

Mismatch-repair deficient (MMRd) colorectal cancers (CRC) are classified based on MMR protein loss and BRAF-V600E mutations. BRAF-wild-type(wt) sporadic MMRd tumors exhibit a diverse landscape of alternative oncogenes, including gene fusions, with unclear biologic and clinical significance. We evalu…

IL-7 is a critical cytokine in T cell development, survival, and homeostasis. Previous preclinical and clinical studies reported that IL-7 treatment increased T cell counts, but its effect on peripheral blood T cells in cancer patients and molecular mechanisms have not been explored….

In a phase I clinical trial, patients with oral precancers who received immunotherapy injected directly into their lesions experienced tumor shrinkage and no dose-limiting toxicities. The findings suggest that immunotherapy could play a role in cancer prevention….

The Meet-URO score, incorporating IMDC classification, neutrophil-to-lymphocyte ratio (NLR), and bone metastases, was developed in European patients receiving second-line nivolumab; its applicability to Asian populations, particularly in real-world first-line immune checkpoint inhibitor (ICI)-based …

Metastatic urothelial carcinoma has undergone a major therapeutic transition, with first-line immune checkpoint inhibitor-based combinations now established as standard care. In this context, the key clinical question is no longer whether early immunotherapy should be used, but how evidence from his…

The role of P2X7R in promoting inflammation during atherosclerosis is well established; however, the effects of curcumin on P2X7R-related pathways remain poorly understood. This study investigates how curcumin affects P2X7R and related targets like NOX1, MMP-3, and TGF-β in ox-LDL-treated macr…

Lymphoma is a heterogeneous hematological malignancy with limited effective therapies. Oncolytic vaccinia virus (OVV) is a promising immunotherapy, but its monotherapeutic efficacy is suboptimal, showing weak antitumor activity in murine lymphoma models and inducing an immunosuppressive tumor microe…

Intravesical Bacillus Calmette-Guerin (BCG) is a live attenuated vaccine for tuberculosis. Intravesical BCG (iBCG) administration is a highly effective immunotherapy for non-muscle invasive bladder cancer (NMIBC). Although live attenuated vaccines are generally contraindicated in solid organ transpl…

BackgroundHyperthyroidism is an immune-related adverse event associated with ICI use. Its underlying risk factors, progression to thyroiditis, and impact on patient outcomes remain less understood.MethodsData were obtained from the TriNetX network for patients aged ≥ 18 y…

Intracellular ion homeostasis is essential for cellular function; tumor cells remodel ion networks to sustain malignant proliferation. Targeting ion homeostasis represents a promising anticancer strategy. Cuproptosis and ferroptosis, emerging programmed cell death modalities, exploit tumor-specific …

Metal ion interference therapy disrupts ion homeostasis to stimulate immunity, but the underlying mechanisms remain poorly elucidated. Here, a hydrazide hyaluronan-decorated copper/zinc disruptor is constructed to inhibit tumoral energy metabolism and activate anticancer immunity. Functionally, Zn2+…

Correction for ‘MnO2-based nanoparticles remodeling tumor micro-environment to augment sonodynamic immunotherapy against breast cancer’ by Haiqin Liao et al., Biomater. Sci., 2025, 13, 2767-2782, https://doi.org/10.1039/D5BM00189G….

Immune checkpoint blockade targeting the PD-1/PD-L1 axis has revolutionized cancer therapy, yet the frequent emergence of resistance limits its clinical efficacy. Elucidating the mechanisms underlying resistance and developing effective strategies remain critical challenges in tumor immunotherapy. T…

Colorectal cancer (CRC) is one of the most common malignancies of the gastrointestinal tract and remains a leading cause of cancer-related mortality. Hypoxia and pyroptosis are closely linked to malignant progression and may shape tumour biology and the immune microenvironment….

Urothelial bladder cancer (BCa) is marked by high recurrence and mortality, and the efficacy of PD-1/PD-L1 immunotherapy remains limited because of immune evasion. The adenosinergic pathway (AP), mediated by ectonucleotidases CD39 and CD73, is a key immunosuppressive mechanism, but its role in BCa r…

Activation of the stimulator of interferon gene (STING) pathway represents a highly promising therapeutic strategy for cancer immunotherapy. However, the clinical translation of STING agonist monotherapy is hindered by inconsistent efficacy and the rapid emergence of drug resistance, particularly du…

Akkermansia (Akk) is a commensal bacterium in gut microbiota known to enhance anti-tumor immunity and improve responses to immunotherapy. However, the clinical translation of Akk-based therapies still faces critical challenges, including intestinal colonization difficulties, inter-patient variabilit…

Meningioma is the most common primary brain tumor. Surgical resection and, in some cases, adjuvant radiotherapy remain the cornerstone of treatment, offering an exceptionally high cure rate. However, treatment can be challenging, particularly in cases of high-grade tumors, symptomatic tumors located…

Although immunotherapy has transformed the treatment of several genitourinary malignancies, its role in prostate cancer remains limited. Combining immunotherapy with targeted therapies has emerged as a promising approach to enhance immune responses in prostate cancer. We aimed to systematically eval…

Immune checkpoint inhibitors (ICIs) have fundamentally reshaped the therapeutic paradigm for metastatic colorectal cancer (mCRC). Beyond the established dMMR/MSI-H population, a molecularly distinct, hyper-immunogenic subset-governed by pathogenic aberrations in the exonuclease domains of POLE/POLD1…

Living microbial therapeutics have arisen as a novel category of medications that extend beyond traditional small molecules and biologics. Advancements in synthetic biology have facilitated the rational engineering of microorganisms to detect host or disease-related signals and administer therapeuti…

Lung cancer, particularly nonsmall cell lung cancer (NSCLC), poses significant therapeutic challenges due to frequent late-stage diagnosis and limited treatment efficacy. While chemoimmunotherapy has emerged as a promising approach, its clinical application is hampered by systemic toxicity and pharm…

The integration of immune checkpoint inhibitors has transformed the therapeutic landscape for patients with resectable and potentially resectable stage III non-small cell lung cancer, providing unprecedented opportunities for curative treatment. Several trials have investigated immune checkpoint inh…

To evaluate and compare the marginal adaptation of two resin-matrix ceramic inlays and assess the influence of aging….

Hypoxia is a pervasive and spatially heterogeneous hallmark of hepatocellular carcinoma (HCC) that drives therapy resistance and motivates the use of hypoxia-activated prodrugs (HAPs) such as tirapazamine (TPZ). To synchronize hypoxia-activated chemotherapy with photodynamic therapy (PDT) and photot…