2026년 4월 20일 Pubmed Today

The use of integrated large-scale, multidomain datasets with artificial intelligence (AI) is now essential in drug discovery and development. Organizations that strategically invest in robust data infrastructure and fit-for-purpose AI solutions will accelerate the delivery of precision oncology ther…

Endometrial cancer (EC) is a common malignant tumor in women, originating from the endometrial epithelium. Molecular classification of EC aids in guiding treatment, assessing prognosis, and screening for Lynch syndrome. Detection of mismatch repair (MMR) deficiency and microsatellite instability (MS…

X-ray triggered local activation of prodrugs is promising for tumor radio-chemo-immunotherapy. However, the insufficient active drugs within tumors under prescribed X-ray doses lead to poor immunogenic effects. Here, we proposed to develop ClO–responsive nanoprodrug (DOX/S-M) that could persistentl…

Lung adenocarcinoma (LUAD) remains a major cause of cancer mortality, highlighting the need for biomarkers that integrate tumor-intrinsic biology with immune contexture. Barrier-to-autointegration factor 1 (BANF1), a chromatin-associated protein involved in nuclear envelope assembly and DNA damage r…

Basal-like breast cancer (BLBC) is characterized as the most aggressive and poorly understood breast cancer (BC) subtype. Next to surgery, conventional chemotherapy and immunotherapy, radiotherapy (RT) represents one of the primary treatment options. Transcriptional plasticity is largely responsible…

Neoadjuvant immunotherapies (NITs) have demonstrated clinical benefit in head and neck carcinoma and other cancers by enhancing T cell-mediated anti-tumor immunity. However, disease recurrence remains a major challenge in a significant proportion of patients. Characterization of T cell dynamics unde…

Mitochondrial dysfunction is a prominent hallmark of aging contributing to the decline of metabolic plasticity in late life. While genetic distortions of mitochondrial integrity elicit premature aging, the mechanisms leading to “natural” aging of mitochondria are less clear. Here we use proteomics, …